Episode 16 of LRSM.  Mysterio, under the guise of Dr. Ludwig Rinehart, tries to convince Spider-Man that he is insane. Professor Spencer Smythe makes a Spider-Slayer robot to hunt Spider-man with J.Jonah Jameson’s face.  Speaking of faces, also in issue 25 is the first appearance of Mary Jane Watson but her face… is obscured.  Eddie calls Betty Brant a high school dropout.  James B says that Flash Thompson is no longer Peter Parker’s Nemesis.