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The Red Journal in coordination with its partners at the Virtual Visiting Professor Network organized a discussion of "The Big Debate: Where Must Radiation Oncology Go First in the 2020s?" This month's podcast features the five speakers: Dr. Wendy Woodward representing Molecular Biology, Dr. Chuck Mayo representing Artificial Intelligence, Dr. Dan Golden representing Education, Dr. Karen Winkfield representing Diversity/Equity/Inclusion, and Dr. Peter Maxim representing FLASH radiotherapy. The challenges, responsibilities, and special insights arising from these varied disciplines will shape the future of our specialty.