Is your gut microbiome the most important organ you're ignoring? In this episode of The Dan Buettner Podcast, world-renowned geneticist and epidemiologist Dr. Tim Spector reveals groundbreaking research on why the microbes in your gut are the ultimate indicator of your health and resilience.

Drawing from a massive study of 300,000 samples recently published in Nature, Dr. Spector explains a startling "health gap": why American gut health is significantly worse than that of Europeans. We explore why a stool test may provide more critical health insights than a standard blood or DNA test, and how the "30-plant rule" can fundamentally reprogram your immune system.

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What if your goal for 2026 wasn't just to feel better, but to live 10 to 15 years longer? According to Dr. David Agus, one of the world’s leading medical visionaries, we are currently at a tipping point where rapid advancements in AI and medicine can radically extend your lifespan in just a few short years. In this special "Future-Proof" edition of our New Year’s Refresh, the Ellison Medical Institute head joins us to bridge the gap between cutting-edge technology and the ancient wisdom of the natural world. From the secret cancer-fighting abilities of elephants to the high-tech diagnostic power of AI, Dr. Agus provides a masterclass in modern longevity.

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In this episode of the Dan Buettner Podcast, Dan sits down with board-certified OB-GYN and celebrity health expert Dr. Jessica Shepherd to uncover the surprising intersection between menopause and longevity. While we often associate menopause with hot flashes, the reality is far more complex—affecting everything from your brain health and sleep to your hair and life expectancy.

Dr. Shepherd explains why women’s life expectancy has jumped by 20 years since the early 1900s, yet our biological clocks haven't caught up. We dive into the science of ""delaying"" menopause not just for reproduction, but for the long-term vitality that estrogen provides to every organ in the body.

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Every January, we chase the "New Year, New Me" dream—new house, new job, new body—only to find ourselves back at the same level of satisfaction by February. Why? In this essential New Year’s Refresh episode, we sit down with Dr. Sonja Lyubomirsky, the world-renowned "Doctor of Happiness." She explains the "Hedonic Treadmill"—the scientific reason why chasing life circumstances often leaves us disappointed—and how you can break that cycle to find joy that actually sticks. If your resolution is to simply be happier this year, this is the only data-driven guide you need.

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In this episode of the Dan Buettner Podcast, legendary actress and "happiness expert" Goldie Hawn joins Dan to discuss the real science behind her joyful nature and the surprising struggles she faced early in her career. Despite her public image as a beacon of light, Goldie reveals her personal battle with severe anxiety and panic attacks that began at age 22, just as she was becoming a household name. She shares how she utilized Freudian analysis and later mindfulness to retrain her brain, ultimately leading to the creation of her MindUP program which now helps children worldwide manage their own stress and emotions.

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When we think of a New Year "reset," we usually focus on the waistline—but what about the organ that runs the entire show? In this powerhouse episode of our New Year’s Refresh series, Blue Zones founder Dan Buettner joins world-renowned psychiatrist Dr. Daniel Amen to explore the ultimate resolution: optimizing your brain. If you’re feeling the "brain fog" of the past year or looking to sharpen your focus for the months ahead, this deep dive is your manual for cognitive renewal.

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Is 100 years old "too young" to die? In this historic episode, Dan Buettner (founder of Blue Zones) sits down with Dave Asprey (the "Father of Biohacking") to debate the future of human longevity. While they represent opposite ends of the spectrum—one focusing on beans and community, the other on stem cells and gene therapy—they find surprising middle ground on how to "hack" your environment for a longer, more vibrant life.

Dave Asprey opens up about his personal journey from chronic illness and Asperger’s to founding a global movement. They dive deep into the science of circadian biology, the "dark art" of marketing wellness, and why forgiveness might be the most important biohack of all.

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Forget the restrictive diets and grueling gym schedules—what if the most effective way to "refresh" your life this year is through the heart? In this special New Year’s Re-drop, relationship expert Jillian Turecki challenges the traditional wellness narrative. She reveals why our social and romantic connections are the true foundation of longevity and mental clarity. Whether you are navigating the sting of a recent heartbreak, seeking to deepen your current partnership, or looking to find your "tribe," Jillian provides a roadmap for a total emotional detox.

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In this episode of the Dan Buettner Podcast, culinary icon Andrew Zimmern reveals why the "cheat code" for a longer, happier life starts in the kitchen. Moving far beyond his Bizarre Foods persona, Andrew joins Dan to discuss how simple shifts in how we cook and eat can add up to 11 years to your life expectancy. The conversation blends expert culinary hacks with a powerful look at sustainable eating and the benefits of small silver fish. But the heart of the episode lies in Andrew’s raw vulnerability as he reflects on his journey from homelessness and addiction to 32 years of sobriety. From relationship advice and "being the dog" for mental wellness to the transformative power of helping others, this episode is a masterclass in resilience and the joy of living well. Tune in for an inspiring look at how to master your kitchen and your life.

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While we take a break for the holidays, we wanted to revisit this powerful episode with author and motivational speaker Case Kenny to challenge the biggest myths about purpose and happiness. Case unpacks his philosophy on why loneliness is a choice and provides a roadmap for creating authentic human connection. He shares a surprising truth about how we talk to ourselves, how to get unstuck from a rut, and his step-by-step process for turning self-doubt into a life of purpose. This episode is a practical and inspiring guide to creating a life you love and finding your tribe.

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