Why does bipolar disorder exist? And what if bipolar disorder isn’t just an illness, but also an evolutionary adaptation? Dr. Holly Swartz reveals the evolutionary secrets of bipolar disorder - from flexible circadian rhythms that once helped our ancestors survive, to the creativity and boldness often linked with mania.

(0:00) Evolution

(0:22) Circadian Control in Nature

(1:43) Advantages of Flexible Biological Clocks

(4:48) Risk-Taking & Creativity

Bipolar Explained is a new talkBD series spotlighting expert perspectives on the history, biology, and management of bipolar disorder.

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Dr. Holly A. Swartz is Professor of Psychiatry at the University of Pittsburgh School of Medicine and President of the International Society of Bipolar Disorders (ISBD). She received her undergraduate degree from Harvard College, medical degree from Albert Einstein College of Medicine, and completed her psychiatric residency training at New York Hospital / Cornell University School of Medicine. Dr. Swartz’s research focuses on understanding and optimizing treatments for mood disorders. She is well known for her work evaluating Interpersonal Psychotherapy (IPT) and Interpersonal and Social Rhythm Therapy (IPSRT) as treatments for depression and bipolar disorder. Her research focuses on the role of IPSRT and pharmacotherapy in the management of bipolar II depression and IPT in the management of maternal depression. She is engaged in collaborative projects to develop computational frameworks to model dyadic interpersonal behaviors in relation to psychotherapy process and outcomes and to understand neural correlates of change in chronotherapeutic behavioral interventions. Her research has been funded by the National Institute of Health, National Science Foundation, and the Brain and Behavior Research Foundation.