What kind of epidemic could turn a thriving American city into a ghost town almost overnight?

Join me as I explore the chilling story of the 1878 yellow fever epidemic—a public health disaster that decimated Memphis and echoed far beyond the Mississippi River Valley. While yellow fever had haunted the U.S. since the slave trade, it was the post–Civil War era—with its railroads, riverboats, and lack of national infrastructure—that turned an outbreak into a catastrophe. The fever emptied cities, bankrupted local governments, and revealed just how unprepared the nation was. But in the aftermath came something surprising: a rare moment of national unity and the first federal steps toward epidemic response. This is a haunting chapter of U.S. history, where disease reshaped the map, the economy, and the legacy of Reconstruction.

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