In youth, binge eating is often marked by loss of control eating (LOC-E), defined as difficulty stopping eating and persistent, compulsive food-seeking behaviors that occur even in the absence of physical hunger. In this podcast, Dr. Aaron Keshen discusses his article, titled, "Reduction of Loss of Control Eating in Youth With Attention-Deficit/Hyperactivity Disorder Following Initiation of Stimulant Medication: A Prospective Study." In their article, the authors describe a prospective observational study that aimed to examine changes in LOC-E over a 3-month period in youth with comorbid attention-deficit/hyperactivity disorder and LOC-E who initiated stimulant medication.

The other authors are Colby Price, Elena Koning, Anastasia L. Harris, Nami Trappenberg, Anja Hilbert, Sara Bartel, Jill Chorney, Laura Dixon, Joseph Sadek, Guido K.W. Frank, Victoria Taylor, Wanda Rasmussen, Hanif Chatur, Drew Yamada, and Stuart B. Murray. The article is published in the January-February 2026 issue of The Journal of Clinical Psychopharmacology.

doi: 10.1097/JCP.0000000000002106

Treatment-resistant depression (TRD) is a considerable clinical challenge. Esketamine, in conjunction with an oral antidepressant, is a potential treatment for TRD. In this podcast, Dr. Matteo Lupi discusses his article, "Esketamine and Quality of Life Improvement in Treatment-Resistant Depression Patients: A Real-World Clinical Study." The prospective study described in the report explores the long-term effects of esketamine therapy on subjective quality of life in adults with TRD.

The other contributing authors are Alessandro Carano, Tiziano Acciavatti, Stefano Marini, Marco Palmucci, Elicio Marinucci, Enrico Paolini, Alessandro Gentile, Angelomarco Barioglio, Marco Giri, Domenico De Berardis, and Giovanni Martinotti. The article is published in the January-February 2026 issue of The Journal of Clinical Psychopharmacology. doi: 10.1097/JCP.0000000000002042

Atomoxetine is a selective norepinephrine reuptake inhibitor prescribed for the management of attention-deficit hyperactivity disorder (ADHD). In this podcast, Emily Yamada discusses her article "Atomoxetine as a Viable ADHD Treatment in Breastfeeding Mothers: Evidence From Human Milk Pharmacokinetic Analysis."

In their article, Yamada and her colleagues present data showing that there is minimal transfer of atomoxetine in breast milk, suggesting that maternal atomoxetine use poses a very low risk to breastfed infants, making it a suitable choice for medication management of ADHD in lactating women.

The other contributing authors are Shraddha Trehan, Amy Stark, Kaytlin Krutsch, and Palika Datta. The article is published in the January-February 2026 issue of The Journal of Clinical Psychopharmacology. doi: 10.1097/JCP.0000000000002109

As interest grows in the therapeutic potential of ketogenic diets for bipolar disorder, careful attention must be given to drug-diet interactions. Overlapping mechanisms between therapeutic ketosis and mood-stabilizing agents may offer opportunities for synergistic effects, but may also introduce risks related to altered pharmacokinetics, pharmacodynamics, and additive toxicities. In this podcast, Dina N. Ali, MD, and Jonathan Leung, PharmD, discuss the complex picture of trying to optimize treatment outcomes while many research questions are yet to be answered. Ali and Leung are authors of the commentary, "Diet Drug Interactions: Achieving and Maintaining Ketosis As Adjunct to Psychotropic Polypharmacotherapy," which is published in the November-December 2025 issue of the Journal of Clinical Psychopharmacology.

The other contributing authors are Mark A. Frye, MD; Iain H. Campbell, PhD; Matej Markota, MD; Mikaela M. Hofer, PharmD, and Heather Standorf, PharmD. doi: 10.1097/JCP.0000000000002074

In this podcast, Nicolas Badre, MD, and Eric Geier, MD, PhD, discuss their article, "Anticholinergic Equivalence in Psychotropic Medications: A Guide for Psychiatrists," which is published in the November-December 2025 issue of the Journal of Clinical Psychopharmacology.

Anticholinergic side effects from psychotropic medications are common and can lead to significant adverse events, including cognitive impairment and falls, particularly in vulnerable populations like the elderly. The cumulative anticholinergic burden from multiple medications is a critical concern associated with poorer clinical outcomes. Quantifying this burden is essential for safer prescribing. For their article, they developed a table to provide a practical tool for psychiatrists to quantify and compare the anticholinergic potential of psychotropic medications.

doi: 10.1097/JCP.0000000000002073

A presidential executive order early this year directed federal departments and agencies to address the issue of chronic disease in the United States, including "the prevalence of and threat posed by the prescription of selective serotonin reuptake inhibitors (SSRIs)," with a particular focus on youth.

In this podcast, Dr. Jeffrey R. Strawn discusses his editorial, "Fact Versus Fear: Antidepressants in Children and Adolescents," which is published in the September-October 2025 issue of the Journal of Clinical Psychopharmacology.

In the editorial, Dr. Strawn and his coauthor, Dr. John T. Walkup, write that the framing of the issue in the executive order risks reinforcing stigma and diminishing trust in evidence-based pediatric mental health care. The editorial summarizes the evidence supporting the efficacy, safety, and tolerability of SSRIs in youth and contextualizes these findings within a discussion of the risk of withholding potentially effective treatments due to stigma and misinformation. The editorial is published in the September-October 2025 issue of the Journal of Clinical Psychopharmacology.

doi: 10.1097/JCP.0000000000002054

Many patients view the return of "positive mental health" (PMH) to be their most important goal of treatment for major depressive disorder (MDD). However, few studies have systematically measured PMH or prospectively examined the added value of considering PMH as a treatment predictor of outcomes.

In this podcast, Dr. Somaia Mohamed discusses her article, "How Does Positive Mental Health Affect Next-Step Treatment Outcomes in Treatment-Resistant Depression? A VAST-D Report." Dr. Mohamed and her coauthors found that high PMH scores at baseline were associated with a greater chance of remission.

The article is published in the September-October 2025 issue of the Journal of Clinical Psychopharmacology. In addition to Dr. Mohamed, the other authors are Sidney Zisook, Gary R. Johnson, and Beata Planeta.

doi: 10.1097/JCP.0000000000002051

Antidepressants are in widespread use, but there is considerable variability in how patients respond, with some seeing substantial improvement while others respond only partially or not at all.

In this podcast, Dr. Antonio E. Nardi discusses the many factors that underlie response rates, including psychological factors, personality traits, and medication adherence. There are also some mood conditions such as demoralization that may seem to resemble depression but do not meet all the clinical criteria. Recognizing these different emotional states is crucial for both individuals and clinicians in the treatment of low mood disorders.

Dr. Nardi, along with Drs. Richard I. Shader, Richard Balon, Anthony J. Rothschild, and Larissa Junkes, are the authors of an editorial titled, " 'I am depressed': The many meanings that may underlie variability in response to antidepressants." The editorial is published in the September-October 2025 issue of the Journal of Clinical Psychopharmacology.

doi: 10.1097/JCP.0000000000002053

Examining a patient's family history of medication response is a commonly used method to guide physicians in treatment selection. Though it is widely recommended, there are no published reviews that assess the validity of this approach when treating patients with affective disorders. In this podcast, authors Jeffrey J. Rakofsky, Michael J. Lucido, and Boadie W. Dunlop of the Department of Psychiatry and Behavioral Sciences at Emory University discuss their article, "A Systematic Review to Determine if Family History of Response to Medication Predicts Outcome in Mood Disorders," which is published in the July-August 2025 issue of the Journal of Clinical Psychopharmacology. In their analysis, the evidence supporting using family history is weak and should be considered as just one piece of the puzzle that should not override other considerations. doi: 10.1097/JCP.0000000000002011

There is considerable evidence that marketing affects physician prescribing practices, even though physicians themselves may not feel that they are influenced. In a thought-provoking editorial, Dr. Jeffrey A. Mattes explores how e-prescribing systems may be one pathway through which pharmaceutical messaging may shape prescribing behavior. In this podcast, Dr. Mattes discusses his editorial, "How Does Drug Company Marketing Affect Physician Prescribing?" which is published in the July-August 2025 issue of the Journal of Clinical Psychopharmacology. doi: 10.1097/JCP.0000000000002030