Toby Maher joins us to discuss results of a randomised, double-blind, placebo-controlled, proof-of-concept trial of ENV-101, an oral inhibitor of the hedgehog signalling pathway, in patients with idiopathic pulmonary fibrosis.

Read the full article:

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00239-5/fulltext?dgcid=buzzsprout_icw_podcast_September_25_lanres

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Professors Guy Brusselle and Celeste Porsbjerg join us to discuss their recent Series papers on asthma, which will be featured in a cross journal project with The Lancet, published to coincide with a Lancet journal session on asthma at ERS in Amsterdam. 

The Series aims to provide an overview of recent research advances related to asthma; to provide new insights into the genetics, prevention and risk factors for asthma; review advances arising as a result of the use of monoclonal antibody therapeutics; and assess remission in adult patients. Late breaking research will also be included within the journal session and linked to the Series.

Read the full Series:

https://www.thelancet.com/series-do/asthma-2025?dgcid=buzzsprout_icw_podcast_asthma25_lanres

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Diana Stanley, Deputy Editor at The Lancet Respiratory Medicine, is joined by Dr Joan Soriano to discuss a new series on the global epidemiology of respiratory disease, exploring the diagnostic challenges, global trends, and future directions for prevention.

Read the full Series:

https://www.thelancet.com/series-do/global-epidemiology-chronic-respiratory-disease?dgcid=buzzsprout_icw_podcast_lanrescrd25_lanres

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Carole Mitnick & Lorenzo Guglielmetti join Ari Colosio, deputy editor of The Lancet Respiratory Medicine, to discuss the ENDTB-Q trial to evaluate the efficacy and safety of a drug regiment to treat TB in individuals with pre-extensively drug-resistant tuberculosis.

Read the full article:

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00194-8/fulltext?dgcid=buzzsprout_icw_podcast_July_25_lanres

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This episode is in Italian. For the English version, please see the main feed.

Lorenzo Guglielmetti sul trial clinico ENDTB-Q per valutare l’efficacia e la sicurezza di un regime di farmaci per curare la tubercolosi in individui con tubercolosi pre-estesa farmaco-resistente.

Leggi l'articolo completo:

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00194-8/fulltext?dgcid=buzzsprout_icw_podcast_July_25_lanres

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Deputy editor Ari Colosio speaks with Dr. Laura Garriga-Grimau of the Val d’Hebron Hospital, Autonomous University of Barcelona. Dr. Garriga-Grimau discusses the first multi-country cohort study to describe the clinical features and standards of care for children and young people with bronchiectasis, drawing on data from the International Pediatric Bronchiectasis Registry.

Together, they examine key findings on regional differences in diagnosis, co-morbidities, clinical severity, and treatment practices across eight countries. Dr. Garriga-Grimau highlights the significant burden of bronchiectasis on patients and health systems, as well as the urgent need for earlier diagnosis, harmonised international guidelines, and more equitable research and care.

Read the full article:

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00089-X/abstract?dgcid=buzzsprout_icw_podcast_July_25_lanres

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Bianca Brandon is joined by Professor Marcus Schultz and Dr Prashant Nasa to discuss their recent Position Paper reporting insights from an international Delphi expert panel on defining and subphenotyping ARDS. The findings underscore the need to refine the ARDS definition to better address heterogeneity of the condition and improve diagnostic precision, with use of subphenotyping where appropriate.

Read the full article:

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00115-8/fulltext?dgcid=buzzsprout_icw_podcast_Jun_25_lanres

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Bianca Brandon, Senior Editor at The Lancet Respiratory Medicine, is joined by Professor Hjalmar Bouma to discuss a new review on sepsis in immunocompromised patients, exploring the diagnostic challenges, complexities of immune status, and future directions for targeted therapies. The episode also analyses the increased vulnerability of specific patient groups, the importance of biomarker-driven personalised medicine, and the need for improved representation of immunosuppressed patients in clinical trials. 

Read the full article:

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00124-9/fulltext?dgcid=buzzsprout_icw_podcast_May_25_lanres

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Deputy Editor of The Lancet Respiratory Medicine Ari Colosio discusses the critical findings of a new epidemiological study on pulmonary embolism in children and adolescents with Simon Wolf from the University Hospital of Zurich. 

This episode delves into the prevalence, risk factors, and clinical implications of this rare but serious condition, highlighting the need for increased awareness and further research.

Read the full article:

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00412-0/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanres

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Dr Sandeep Sahay and Professor Franck Rahaghi discuss their Personal View on future treatment paradigms in pulmonary arterial hypertension.

Read the full paper, Future treatment paradigms in pulmonary arterial hypertension: a personal view from physicians, health authorities, and patients, here: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00425-9/fulltext

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