Dr. Dugel discusses 1 and 2 year results of HAWK and HARRIER on Brolucizumab for neovascular AMD.

Full reference:

Dugel, P. U., Koh, A., Ogura, Y., Jaffe, G. J., Schmidt-Erfurth, U., Brown, D. M., . . . Investigators, H. S. (2019). HAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration. Ophthalmology. doi:10.1016/j.ophtha.2019.04.017

Dr. Sun discusses Protocol V results that investigated efficacy of 3 treatment approaches for DME in eyes with vision of 20/25 or better: aflibercept injections, focal laser, or observation.

Reference to the publication:

Baker CW, Glassman AR, Beaulieu WT, Antoszyk AN, Browning DJ, Chalam KV, Grover S, Jampol LM, Jhaveri CD8, Melia M, Stockdale CR, Martin DF, Sun JK; DRCR Retina Network. Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity: A Randomized Clinical Trial. JAMA. 2019 Apr 29. doi: 10.1001/jama.2019.5790.

Dr. Tamer Mahmoud discusses an innovative surgical method for closure of refractory macular holes using autologous retinal transplants.

Full reference of the discusses article:

Grewal, D. S., Charles, S., Parolini, B., Kadonosono, K., & Mahmoud, T. H. (2019). Autologous Retinal Transplant for Refractory Macular Holes: Multicenter International Collaborative Study Group. Ophthalmology. doi:10.1016/j.ophtha.2019.01.027

Dr. Mark Gillies from Sydney, Australia discusses 2-year results of the RIVAL Study which investigated rates of geographic atrophy and visual acuity changes in patients with wet AMD.

Full reference:

Gillies, M. C., Hunyor, A. P., Arnold, J. J., Guymer, R. H., Wolf, S., Ng, P., . . . McAllister, I. L. (2019). Effect of Ranibizumab and Aflibercept on Best-Corrected Visual Acuity in Treat-and-Extend for Neovascular Age-Related Macular Degeneration: A Randomized Clinical Trial. JAMA Ophthalmol. doi:10.1001/jamaophthalmol.2018.6776

Dr. Richard Rosen discusses a review of perfusion density changes (measured by OCT-Angiography) as measured before and immediately after intravitreal injections.

Full reference of the article:

Barash, A., Chui, T. Y. P., Garcia, P., & Rosen, R. B. (2019). Acute Macular and Peripapillary Angiographic Changes with Intravitreal Injections. Retina. doi:10.1097/IAE.0000000000002433

Dr. Peter Kertes discusses the publication of the first year results of the CANTREAT study that investigates monthly vs treat-and-extend dosing of ranibizumab for wet AMD.

Full reference:

Kertes, P. J., Galic, I. J., Greve, M., Williams, R. G., Rampakakis, E., Scarino, A., & Sheidow, T. (2019). Canadian Treat and Extend Analysis Trial with Ranibizumab in Patients with Neovascular Age-related Macular Disease: 1-Year Results of the Randomized CANTREAT Study. Ophthalmology. doi:10.1016/j.ophtha.2019.01.013

Dr. Schrag discusses his publication on the prevalence of cardiovascular risk factors in patients who present with Central Retinal Artery Occlusion.

Discussed article:

Lavin, P., Patrylo, M., Hollar, M., Espaillat, K. B., Kirshner, H., & Schrag, M. (2018). Stroke Risk and Risk Factors in Patients With Central Retinal Artery Occlusion. Am J Ophthalmol, 196, 96-100. doi:10.1016/j.ajo.2018.08.027

Dr. Jason Hsu discusses the review of patients with PDR who were lost to followup after limited anti-VEGF or PRP treatment and returned for treatment after at least 6 mo.

Full reference:

Obeid, A., Su, D., Patel, S. N., Uhr, J. H., Borkar, D., Gao, X., . . . Hsu, J. (2018). Outcomes of Eyes Lost to Follow-up with Proliferative Diabetic Retinopathy That Received Panretinal Photocoagulation versus Intravitreal Anti-Vascular Endothelial Growth Factor. Ophthalmology. doi:10.1016/j.ophtha.2018.07.027

Drs. Muni and Hillier discuss the results of the PIVOT study that prospectively compared results of pneumatic retinopexy vs. pars plana vitrectomy for repair of rhegmatogenous retinal detachment.

This podcast episode is simulcast with the online appearance of the article.

Full reference:

Hillier, R. J., Felfeli, T., Berger, A. R., Wong, D. T., Altomare, F., Dai, D., . . . Muni, R. H. (2018). The Pneumatic Retinopexy versus Vitrectomy for the Management of Primary Rhegmatogenous Retinal Detachment Outcomes Randomized Trial (PIVOT). Ophthalmology. doi:10.1016/j.ophtha.2018.11.014

Professor Robyn Guymer from Melbourne, Australia discusses results of the LEAD trial that investigated the use of nanopulase laser for dry AMD.

Full reference of the article:

Guymer, R. H., Wu, Z., Hodgson, L. A. B., Caruso, E., Brassington, K. H., Tindill, N., . . . Laser Intervention in Early Stages of Age-Related Macular Degeneration Study, G. (2018). Subthreshold Nanosecond Laser Intervention in Age-Related Macular Degeneration: The LEAD Randomized Controlled Clinical Trial. Ophthalmology. doi:10.1016/j.ophtha.2018.09.015