Dr. Philip Hykin discusses the LEAVO trial which was a large prospective trial comparing the efficacy of three main anti-VEGF intravitreal injections (bevacizumab, ranibizumab and aflibercept) for treating macular edema secondary to Central Retinal Vein Occlusion.

The discussed article:

Clinical Effectiveness of Intravitreal Therapy With Ranibizumab vs Aflibercept vs Bevacizumab for Macular Edema Secondary to Central Retinal Vein Occlusion: A Randomized Clinical Trial.

Hykin P, Prevost AT, Vasconcelos JC, Murphy C, Kelly J, Ramu J, Hounsome B, Yang Y, Harding SP, Lotery A, Chakravarthy U, Sivaprasad S; LEAVO Study Group. JAMA Ophthalmol. 2019 Aug 29. doi:10.1001/jamaophthalmol.2019.3305.

Dr. Vander from Wills Eye Hospital discusses the effect of vitreous tap on the management of 60 cases of endophthalmitis post intravitreal anti-VEGF injections.

The discussed article:

Changes in Management Based on Vitreous Culture in Endophthalmitis After Intravitreal Anti-vascular Endothelial Growth Factor Injection. Patel SN, Storey PP, Pancholy M, Obeid A, Wibbelsman TD, Levin H, Hsu J, Garg SJ, Dunn JP, Vander JF. Am J Ophthalmol. 2019 Nov;207:224-231. doi: 10.1016/j.ajo.2019.06.008. Epub 2019 Jun 13

Dr. Guymer discusses the results of the FLUID study which investigated whether some residual sub retinal fluid can be tolerated in neovascular macular degeneration.

Full reference:

Tolerating Subretinal Fluid in Neovascular Age-Related Macular Degeneration Treated with Ranibizumab Using a Treat-and-Extend Regimen. Guymer, Robyn H.Chang, Andrew et al. Ophthalmology, Volume 126, Issue 5, 723 - 734

Dr. Soliman discusses his team's analysis of clinical predictors of low histopathology in eyes that were enucleated because of retinoblastoma. The goal of the study is to find clinical indicators in retinoblastoma that could be used to salvage eyes via eye-preserving treatment methods instead of enucleation.

Drs. Muni and Juncal discuss their case series on the level of anti-VEGF drugs and VEGF-A levels on lactating mothers who had received intravitreal anti-VEGF injections.

Reference for the article:

Ranibizumab and Aflibercept Levels in Breast Milk after Intravitreal Injection; Verena R. Juncal,Quratulain Paracha,Motaz Bamakrid, ,Carolina L.M. Francisconi, Julia Farah, Amin Kherani ,Rajeev H. Muni; Ophthalmology, published on line Sep.11, 2019

https://doi.org/10.1016/j.ophtha.2019.08.022

Dr. Dugel discusses 1 and 2 year results of HAWK and HARRIER on Brolucizumab for neovascular AMD.

Full reference:

Dugel, P. U., Koh, A., Ogura, Y., Jaffe, G. J., Schmidt-Erfurth, U., Brown, D. M., . . . Investigators, H. S. (2019). HAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration. Ophthalmology. doi:10.1016/j.ophtha.2019.04.017

Dr. Sun discusses Protocol V results that investigated efficacy of 3 treatment approaches for DME in eyes with vision of 20/25 or better: aflibercept injections, focal laser, or observation.

Reference to the publication:

Baker CW, Glassman AR, Beaulieu WT, Antoszyk AN, Browning DJ, Chalam KV, Grover S, Jampol LM, Jhaveri CD8, Melia M, Stockdale CR, Martin DF, Sun JK; DRCR Retina Network. Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity: A Randomized Clinical Trial. JAMA. 2019 Apr 29. doi: 10.1001/jama.2019.5790.

Dr. Tamer Mahmoud discusses an innovative surgical method for closure of refractory macular holes using autologous retinal transplants.

Full reference of the discusses article:

Grewal, D. S., Charles, S., Parolini, B., Kadonosono, K., & Mahmoud, T. H. (2019). Autologous Retinal Transplant for Refractory Macular Holes: Multicenter International Collaborative Study Group. Ophthalmology. doi:10.1016/j.ophtha.2019.01.027

Dr. Mark Gillies from Sydney, Australia discusses 2-year results of the RIVAL Study which investigated rates of geographic atrophy and visual acuity changes in patients with wet AMD.

Full reference:

Gillies, M. C., Hunyor, A. P., Arnold, J. J., Guymer, R. H., Wolf, S., Ng, P., . . . McAllister, I. L. (2019). Effect of Ranibizumab and Aflibercept on Best-Corrected Visual Acuity in Treat-and-Extend for Neovascular Age-Related Macular Degeneration: A Randomized Clinical Trial. JAMA Ophthalmol. doi:10.1001/jamaophthalmol.2018.6776

Dr. Richard Rosen discusses a review of perfusion density changes (measured by OCT-Angiography) as measured before and immediately after intravitreal injections.

Full reference of the article:

Barash, A., Chui, T. Y. P., Garcia, P., & Rosen, R. B. (2019). Acute Macular and Peripapillary Angiographic Changes with Intravitreal Injections. Retina. doi:10.1097/IAE.0000000000002433