Drs. Lee and Apte discuss their recent paper on our current understanding of using retinal imaging biomarkers to evaluate Alzheimer's disease.

Discussed article:

Lee CS, Apte RS, Retinal Biomarkers of Alzheimer's Disease, American Journal of Ophthalmology (2020), doi: https://doi.org/10.1016/j.ajo.2020.04.040.

Dr. Gupta discusses findings of this large retrospective study on the risk and associations of rhegmatogenous retinal detachment after intravitreal anti-VEGF injections.

Discussed article:

In a panel discussion with Dr. Koushan, Drs. Daniel Ting, Olivia Li and Steven Yeh discuss the preparedness of ophthalmologists in the COVID-19 crisis. The discussion is based on the most recent Ophthalmology editorial:

Preparedness among Ophthalmologists: During and Beyond the COVID-19 Pandemic. Olivia Li, Ji-PengWong, Tien Y.Wong, Edmund Y.Mehta, JodLin, HaotianLin, XiaofengStrouthidis, Nicholas G.Park, Ki HoFung, Adrian T.McLeod, Stephen D.Busin, MassimoParke, David W.Holland, Gary N.Chodosh, JamesYeh, StevenTing, Daniel S.W. et al. Ophthalmology, Volume 127, Issue 5, 569 - 572

Dr. Leffler discusses his team's analysis of the country-wide mortality from COVID-19 pandemic and its correlation with mask usage by the public.

Full reference:

Leffler CT, Ing E, McKeown CA, Pratt D, Grzybowski A. Final Country-wide Mortality from the Novel Coronavirus (COVID-19) Pandemic and Notes Regarding Mask Usage by the Public. April 4, 2020. Available from: researchgate.net.

Dr. Shildkrot discusses progression of glaucomatous changes in 28 eyes that were receiving anti-VEGF injections.

Discussed article:

Effects of Intravitreal Anti-VEGF Therapy on Glaucoma-like Progression in Susceptible Eyes, Du, Jeanette MD; Patrie, James T ; Prum, Bruce E.; Netland, Peter A.; Shildkrot, Yevgeniy (Eugene) MD, Journal of Glaucoma: December 2019 - Volume 28 - Issue 12 - p 1035-1040

doi: 10.1097/IJG.0000000000001382

Dr. Philip Hykin discusses the LEAVO trial which was a large prospective trial comparing the efficacy of three main anti-VEGF intravitreal injections (bevacizumab, ranibizumab and aflibercept) for treating macular edema secondary to Central Retinal Vein Occlusion.

The discussed article:

Clinical Effectiveness of Intravitreal Therapy With Ranibizumab vs Aflibercept vs Bevacizumab for Macular Edema Secondary to Central Retinal Vein Occlusion: A Randomized Clinical Trial.

Hykin P, Prevost AT, Vasconcelos JC, Murphy C, Kelly J, Ramu J, Hounsome B, Yang Y, Harding SP, Lotery A, Chakravarthy U, Sivaprasad S; LEAVO Study Group. JAMA Ophthalmol. 2019 Aug 29. doi:10.1001/jamaophthalmol.2019.3305.

Dr. Vander from Wills Eye Hospital discusses the effect of vitreous tap on the management of 60 cases of endophthalmitis post intravitreal anti-VEGF injections.

The discussed article:

Changes in Management Based on Vitreous Culture in Endophthalmitis After Intravitreal Anti-vascular Endothelial Growth Factor Injection. Patel SN, Storey PP, Pancholy M, Obeid A, Wibbelsman TD, Levin H, Hsu J, Garg SJ, Dunn JP, Vander JF. Am J Ophthalmol. 2019 Nov;207:224-231. doi: 10.1016/j.ajo.2019.06.008. Epub 2019 Jun 13

Dr. Guymer discusses the results of the FLUID study which investigated whether some residual sub retinal fluid can be tolerated in neovascular macular degeneration.

Full reference:

Tolerating Subretinal Fluid in Neovascular Age-Related Macular Degeneration Treated with Ranibizumab Using a Treat-and-Extend Regimen. Guymer, Robyn H.Chang, Andrew et al. Ophthalmology, Volume 126, Issue 5, 723 - 734

Dr. Soliman discusses his team's analysis of clinical predictors of low histopathology in eyes that were enucleated because of retinoblastoma. The goal of the study is to find clinical indicators in retinoblastoma that could be used to salvage eyes via eye-preserving treatment methods instead of enucleation.

Drs. Muni and Juncal discuss their case series on the level of anti-VEGF drugs and VEGF-A levels on lactating mothers who had received intravitreal anti-VEGF injections.

Reference for the article:

Ranibizumab and Aflibercept Levels in Breast Milk after Intravitreal Injection; Verena R. Juncal,Quratulain Paracha,Motaz Bamakrid, ,Carolina L.M. Francisconi, Julia Farah, Amin Kherani ,Rajeev H. Muni; Ophthalmology, published on line Sep.11, 2019

https://doi.org/10.1016/j.ophtha.2019.08.022