In this first episode of The Price of PRRS series, host Dr. Lindsay Case, PIC Technical Director of Product Sustainability, is joined by Dr. Perry Harms, PIC Health Assurance Global Director, and Dr. Derald Holtkamp, Professor in the College of Veterinary Medicine at Iowa State University, to explore the economic burden of one of the most costly diseases in swine production—Porcine Reproductive and Respiratory Syndrome (PRRS). Together, they break down what makes PRRS such a persistent challenge for producers, the factors that drive its financial impact, and why understanding the true cost is the first step toward long-term solutions.