The Stem Cell Report with Janet Rossant

In this episode of The Stem Cell Report, Martin Pera is joined by Douglas Melton, a pioneer in the use of stem cell-based transplants to treat Type 1 diabetes, and Nayara Leite, a former postdoc in the Melton laboratory who now works for Vertex Pharmaceuticals, one of the companies currently testing stem cell-derived transplants for diabetes in clinical trials. Drs. Melton and Leite will talk about the concepts and issues around stem cell-based treatments for diabetes and their new paper that looks at ways to enhance the survival and function of the insulin producing islets.

Guests
Douglas Melton, PhD, Harvard University 
Nayara Leite, PhD, Vertex Pharmaceuticals

Host
Martin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory
Twitter: @martinperaJAX

Read Their Paper
Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro

About Stem Cell Reports
Stem Cell Reports is the Open Access journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.
Twitter: @StemCellReports

About ISSCR
With nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.
Twitter: @ISSCR

Acknowledgement

ISSCR Staff
Keith Alm, Chief Executive Officer
Bethany Almon, Senior Manager of Integrated Marketing
Yvonne Fisher, Managing Editor, Stem Cell Reports
Kym Kilbourne, Director of Media and Strategic Communications
Jack Mosher, Scientific Advisor

Voice Work
Ben Snitkoff

Music
@Konovalov

In this episode of the Stem Cell Report, Martin Pera is joined by a team of scientists from the Neural Stem Cell Institute in Rensselaer, NY, USA.  Drs. Elizabeth Fisher, Xiuli Zhao, and Institute Director Sally Temple talk about their new paper on neural stem and progenitor cell function in the aging adult brain. They use live time-lapse imaging with computer-based image analysis to assess young and aged neural stem and progenitor cells in 3D brain structures to assess the mechanism underlying changes to the aging brain. 

Guests
Sally Temple, PhD, Neural Stem Cell Institute
Xiuli Zhao MD, PhD, Neural Stem Cell Institute
Elizabeth Fisher, PhD, Neural Stem Cell Institute 

Host
Martin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory
Twitter: @martinperaJAX

Read Their Paper
4D imaging analysis of the aging mouse neural stem cell niche reveals a dramatic loss of progenitor cell dynamism regulated by the RHO-ROCK pathway 

About Stem Cell Reports
Stem Cell Reports is the Open Access journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.
Twitter: @StemCellReports

About ISSCR
With nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.
Twitter: @ISSCR

Acknowledgement

ISSCR Staff
Keith Alm, Chief Executive Officer
Bethany Almon, Senior Manager of Integrated Marketing
Yvonne Fisher, Managing Editor, Stem Cell Reports
Kym Kilbourne, Director of Media and Strategic Communications
Jack Mosher, Scientific Advisor

Voice Work
Ben Snitkoff

Music
@Konovalov

In this episode, Drs. Shimpei Gotoh, Takahiro Suezawa, and Carla Kim join the podcast to talk about using stem and progenitor cells to understand the adult lung and model disease processes impacting lung function. Their research and discoveries provide insight into lung homeostasis, the potential for regeneration, and understanding diseases like pulmonary fibrosis and cancer.

Drs. Gotoh and Suezawa are two of the authors of the recent paper ”Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids” in Stem Cell Reports. Dr Kim is a member of the Stem Cell Reports Editorial Board and an expert in the study of progenitors of the adult lung.

Guests
Shimpei Gotoh, MD, PhD, Kyoto University
Takahiro Suezawa, PhD, Kyorin Pharmaceutical Company
Carla Kim, PhD, Boston Children’s Hospital and Harvard Medical School

Host
Martin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory
Twitter: @martinperaJAX

Supporting Documents
Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids

About Stem Cell Reports
Stem Cell Reports is the Open Access journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.
Twitter: @StemCellReports

About ISSCR
With nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.
Twitter: @ISSCR
Website: https://www.cell.com/stem-cell-reports/home

Acknowledgement

ISSCR Staff
Keith Alm, Chief Executive Officer
Bethany Almon, Senior Manager of Integrated Marketing
Yvonne Fisher, Managing Editor, Stem Cell Reports
Kym Kilbourne, Director of Media and Strategic Communications
Jack Mosher, Senior Manager of Scientific Affairs

Voice Work
Ben Snitkoff

Music
@Konovalov

In this episode, Drs. Fiona Watt and Alice Vickers join the podcast to talk about uncovering the relationship between genetic variants and cellular behavior. They recently developed a platform to quantify iPSC differentiation propensity to investigate the genetic contribution to phenotypic variability. Drs. Vickers and Watt are authors of the recent paper,  "Plating human iPSC lines on micropatterned substrates relevels role for ITGBI nsSNV in endoderm formation” in Stem Cell Reports. 

Guests
Fiona Watt, DPhil, Centre for Stem Cells and Regenerative Medicine, King’s College London
Website: http://www.wattlab.org/ 

Alice Vickers, PhD, INKEF Capital, Amsterdam (current affiliation). Centre for Stem Cells and Regenerative Medicine, King’s College London (previous affiliation).
Website: https://www.inkefcapital.com

Supporting Document
”Plating human iPSC lines on micropatterned substrates relevels role for ITGBI nsSNV in endoderm formation” 

Host
Martin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory
Twitter: @martinperaJAX

About Stem Cell Reports
Stem Cell Reports is the Open Access journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.
Twitter: @StemCellReports

About ISSCR
With nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health. 
Twitter: @ISSCR

Acknowledgements

ISSCR Staff
Keith Alm, Chief Executive Officer
Bethany Almon, Senior Manager of Integrated Marketing
Yvonne Fisher, Managing Editor, Stem Cell Reports
Kym Kilbourne, Director of Media and Strategic Communications
Jack Mosher, Senior Manager of Scientific Affairs

Voice Work
Ben Snitkoff

Music
@Konovalov

In this episode Drs. Charles Murry and Kenta Nakamura join the podcast to talk about “cardiac remuscularization therapy,” and the general approach of transplanting human pluripotent stem cell-derived cardiomyocytes to restore cardiac function after injury.

Guests
Charles Murry, MD, PhD, University of Washington and Sana Biotechnology
Kenta Nakamura, MD, University of Washington and VA Puget Sound Healthcare System 

Host
Martin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory
Twitter: @martinperaJAX

Supporting Document
Drs. Murry and Nakamura are two of the authors of the recent paper ” Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes” in Stem Cell Reports.  

About Stem Cell Reports
Stem Cell Reports is the Open Access journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.
Twitter: @StemCellReports

About ISSCR
With nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.
Twitter: @ISSCR
Website: https://www.cell.com/stem-cell-reports/home

Acknowledgement

ISSCR Staff
Keith Alm, Chief Executive Officer
Bethany Almon, Senior Manager of Integrated Marketing
Yvonne Fisher, Managing Editor, Stem Cell Reports
Kym Kilbourne, Director of Media and Strategic Communications
Jack Mosher, Senior Manager of Scientific Affairs

Voice Work
Ben Snitkoff

Music
@Konovalov

In this episode Drs. Peter Loskill and Christine Mummery join the podcast to talk about the intersection of stem cells, microphysiological systems and organs-on-a-chip technology in understanding disease, screening drugs and personalized medicine. Drs. Loskill and Mummery are guest editors of a special issue on this topic appearing now in Stem Cell Reports. 

Guests
Peter Loskill, PhD W3-Professor for Organ-on-Chip Research at the Eberhard Karls University Tübingen and the Natural and Medical Sciences Institute as well as Vice-Chair of the European-Organ-on-Chip-Society (EUROoCS). 
Twitter: @pe_losk

Christine Mummery, PhD, Professor of Developmental Biology at Leiden University Medical Center and heads the iPSC & organ on a chip facility at the LUMC. She is also the recent past president of the ISSCR.

Host
Martin Pera, PhD, Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory
Twitter: @martinperaJAX

Supporting Documents
Special Issue: Organs-on-Chip

About Stem Cell Reports
Stem Cell Reports is the Open Access journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.
Twitter: @StemCellReports

About ISSCR
With nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.
Twitter: @ISSCR
Website: https://www.cell.com/stem-cell-reports/home

Acknowledgement

ISSCR Staff
Keith Alm, Chief Executive Officer
Bethany Almon, Senior Manager of Integrated Marketing
Yvonne Fisher, Managing Editor, Stem Cell Reports
Kym Kilbourne, Director of Media and Strategic Communications
Jack Mosher, Senior Manager of Scientific Affairs

Voice Work
Ben Snitkoff

Music
@Konovalov

In this episode, sponsored by Bio-Techne, Drs. Hans Clevers and Kai Kretschmar join the podcast to talk broadly about the role of adult stem cells in tissue maintenance and repair. Specifically, they will focus on the expression and function of Troy and stem cells in the development and homeostasis of the epidermis, the outermost layer of the skin, that functions as a protective mechanical and biological barrier against injuries, pathogens and the loss of heat and water.

Guests
Hans Clevers, MD, PhD, is group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and at the Princess Máxima Center for Pediatric Oncology. He is also University Professor at the University Utrecht and Oncode Investigator. Both in the Netherlands. 

Kai Kretzschmar, PhD, is junior group leader at the MSNZ University Hospital Würzburg, Germany 

Host
Martin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory
Twitter: @martinperaJAX

Supporting Documents
Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification

About Stem Cell Reports
Stem Cell Reports is the Open Access journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.
Twitter: @StemCellReports

About ISSCR
With nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.
Twitter: @ISSCR

Acknowledgements

ISSCR Staff
Keith Alm, Chief Executive Officer
Bethany Almon, Senior Manager of Integrated Marketing
Yvonne Fisher, Managing Editor, Stem Cell Reports
Kym Kilbourne, Director of Media and Strategic Communications
Jack Mosher, Scientific Advisor

Voice Work
Ben Snitkoff

Music
@Konovalov

In this episode, sponsored by bit.bio,  Drs. Marius Wernig and Yi Han Ng join the podcast to talk about the directed differentiation of pluripotent stem cells into dopaminergic neurons. Their approach, which is based on the expression of specific transcription factors to drive cell fate directly to a specific neuronal identity, has been demonstrated to robust generalate functional dopaminergic neurons of midbrain character.

Guests
Marius Wernig, MD, PhD, Associate Professor of Pathology at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University
Website: https://www.werniglab.org/

Yi Han Ng, PhD, Institute for Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University School of Medicine and Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore

Supporting Documents
Efficient Generation of Dopaminergic Induced Neuronal Cells with Midbrain Characteristics 

Host
Martin Pera, PhD: Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory
Twitter: @martinperaJAX 

About Stem Cell Reports
Stem Cell Reports is the open access journal of the International Society for Stem Cell Research for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.
Twitter: @StemCellReports

About ISSCR
With nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.
Twitter: @ISSCR

Acknowledgements

ISSCR Staff
Keith Alm, Chief Executive Officer
Bethany Almon, Senior Manager of Integrated Marketing
Yvonne Fisher, Managing Editor, Stem Cell Reports
Kym Kilbourne, Director of Media and Strategic Communications
Jack Mosher, Senior Manager of Scientific Affairs

Voice Work
Julie Perlin
Ben Snitkoff

Music
@Konovalov

In this episode, Drs. Zubin Master, Kirstin Matthews, Mohamed Abou-el-Enein, and Sean Morrison join the podcast to talk about unproven stem cell-based interventions. These so-called “stem cell therapies” or “regenerative therapies” currently being marketed direct-to-consumers have insufficient evidence of safety and efficacy to justify their use and pose a potential risk to recipients. A recent paper from Masters, Mathews and Abou-el-Enein published in Stem Cell Reports discusses this global public health problem.

Guests
Mohamed Abou-El-Enein, MD, PhD, MSPH Keck School of Medicine, University of Southern California, USA
Zubin Master, PhD, Mayo Clinic, USA
Kirstin Matthews, PhD, Baker Institute for Public Policy, Rice University, USA
Sean Morrison, PhD, Children’s Research Institute, UT Southwestern, USA

Host
Martin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory
Website: https://www.jax.org/research-and-faculty/faculty/martin-pera
Twitter: @martinperaJAX

Supporting Documents
Unproven stem cell interventions: A global public health problem requiring global deliberation

About Stem Cell Reports
Stem Cell Reports is the Open Access journal of the International Society for Stem Cell Research for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.

About ISSCR
With nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.
Twitter: @ISSCR 

Acknowledgements
ISSCR Staff
Keith Alm, Chief Executive Officer
Bethany Almon, Senior Manager of Integrated Marketing
Yvonne Fisher, Managing Editor, Stem Cell Reports
Kym Kilbourne, Director of Media and Strategic Communications
Jack Mosher, Senior Manager of Scientific Affairs

Voice Work
Julie Perlin

Music
@Konovalov

In today’s episode, we will talk about new research on the use of an induced pluripotent stem cell-based vaccine to potentially protect against pancreatic cancer. This approach takes advantage of shared antigens between stem cells and pancreatic cancer cells and seeks to exploit them for clinical benefit. We will talk with the authors of this new research published in Stem Cell Reports on why they decided to pursue this approach, the background behind it, and whether this approach could work for other types of cancers. We also discuss some of Dr. Wu's other work, including research on stem cells in microgravity.

Show Notes

Guests
Joseph Wu, MD, PhD Director of the Stanford Cardiovascular Institute,  US
 Website: http://med.stanford.edu/wulab.html

Xiaoming Ouyang, PhD, Postdoctoral Scholar, Wu Laboratory, Stanford University, US
 Website: https://www.researchgate.net/profile/Xiaoming-Ouyang

Host
Martin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory
Website: https://www.jax.org/research-and-faculty/faculty/martin-pera
Twitter: @martinperaJAX

Supporting Documents
Anti-Tumor Effects of iPSC-Based Cancer Vaccine in Pancreatic Cancer
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(21)00199-5

About Stem Cell Reports
Stem Cell Reports is the Open Access journal of the International Society for Stem Cell Research for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.
Twitter: @stemcellreports

About ISSCR
With nearly 4,000 members from more than 65 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.
Twitter: @ISSCR 

Acknowledgements
ISSCR Staff
Keith Alm, Chief Operating Officer
Bethany Almon, Senior Manager of Integrated Marketing
Yvonne Fisher, Managing Editor, Stem Cell Reports
Kym Kilbourne, Director of Media and Strategic Communications
Jack Mosher, Senior Manager of Scientific Affairs
Nancy Witty, Chief Executive Officer

Voice Work
Julie Perlin
Ben Snitkoff

Music
@Konovalov