In the Interim...

The STEP Platform with Dr. Eva Mistry and Dr. Jordan Elm


Listen Later

This episode of "In the Interim..." features an in-depth discussion of the StrokeNet Thrombectomy Endovascular Platform (STEP), a multi-domain, multi-factorial, adaptive platform trial for acute stroke, anchored in the NIH StrokeNet network. Guests Dr. Eva Mistry (University of Cincinnati) and Dr. Jordan Elm (Medical University of South Carolina) join us to explain how STEP enables simultaneous investigation of multiple treatment strategies in patients with acute ischemic stroke. The conversation details the use of a master protocol, the integration of industry partners through the Other Transactional Authority (OTA) NIH mechanism, and innovative statistical designs to efficiently identify improved treatment strategies.

Key Highlights:

  • STEP utilizes a master protocol within NIH StrokeNet, unifying eligibility, procedures, and data collection across all study domains.
  • The platform supports multiple research questions.
  • In an initial domain STEP applies a statistical change-point model to empirically estimate the thresholds where EVT is effective, neutral, or potentially deleterious based on medium vessel occlusions and baseline clinical status. 
  • Protocols may be adapted in response to new external data, including pausing and revising enrollment in specific subpopulations when emerging science warrants.
  • Shared control groups are used wherever applicable, improving trial efficiency by reducing the number of patients allocated to control arms and allowing eligible patients to contribute to multiple domains when protocol and scientific rationale permit.
...more
View all episodesView all episodes
Download on the App Store

In the Interim...By Berry

  • 5
  • 5
  • 5
  • 5
  • 5

5

10 ratings


More shows like In the Interim...

View all
TED Talks Daily by TED

TED Talks Daily

11,184 Listeners

Data Skeptic by Kyle Polich

Data Skeptic

478 Listeners

Political Fix by Financial Times

Political Fix

146 Listeners

Super Data Science: ML & AI Podcast with Jon Krohn by Jon Krohn

Super Data Science: ML & AI Podcast with Jon Krohn

301 Listeners

The Daily by The New York Times

The Daily

112,376 Listeners

Up First from NPR by NPR

Up First from NPR

56,444 Listeners

Learning Bayesian Statistics by Alexandre Andorra

Learning Bayesian Statistics

68 Listeners

Think Fast Talk Smart: Communication Techniques by Matt Abrahams, Think Fast Talk Smart

Think Fast Talk Smart: Communication Techniques

808 Listeners

All-In with Chamath, Jason, Sacks & Friedberg by All-In Podcast, LLC

All-In with Chamath, Jason, Sacks & Friedberg

9,799 Listeners

JAMAevidence JAMA Guide to Statistics and Methods by JAMA Network

JAMAevidence JAMA Guide to Statistics and Methods

19 Listeners

Learning English For Work by BBC News

Learning English For Work

50 Listeners