Recent studies from 5 different countries concur that PPIs, especially in those over the age of 45 and long-term users, are at an increased risk of dementia.

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These were mostly cohort studies in the following countries: US, UK, Denmark, Germany, and Korea.
In the Korean study they saw a 36% increased risk even in short-term users. Something I've heard from patients and those watching this channel.

The US study showed a 33% increased risk in adults over the age of 45 taking PPIs for 4.5 years. This was an observational study.

Denmark's study showed a 42% increase, while Germany saw 44% risk and the UK showed a 22% risk of all-cause dementia and a 43% risk of vascular dementia.

These were not randomized control studies, the gold standard in science, but they were certainly robust studies.

Even if we disregard this research, there are unassailable facts known about PPIs that do put you at risk for dementia.

The decreased acid compromises absorption of vitamin B12, magnesium, protein, plus causes microbiome disfunction.

Vitamin B12 when deficient leads to cognitive impairment, memory loss, mood changes, and elevated homocysteine, linked to Alzheimer's and vascular dementia.

Magnesium deficiency is linked to poor memory, depression and accelerated cognitive decline.

Gut microbiome disruption is linked to increased permeability of the brain and increased risk of Alzheimer's and Parkinson's disease.

Finally, when protein digestion is impaired is can impact your memory and cognition.

My recommendations are to find a clinician who can get to the root cause of why you were put on the PPI and then slowly wean you off it once that root cause has been properly addressed.

Also it's critical to located a clinician comfortable with properly assessing an healing your microbiome.

If you'd like help we're here for you. The best next step is to contact us for a consultation and then we can determine if what we do is a good fit for you. Call 727-335-0400.

#dementia #acidreflux #rootcausemedicine 
Disclaimer: The information provided in this video is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your physician or other qualified health provider with any questions you may have regarding your health, medical condition, or treatment options. Never disregard professional medical advice or delay in seeking it because of something you have seen or heard in this video.
The views expressed are based on my clinical experience and current scientific understanding as of the date of publication. Individual results may vary.