The Dr. Josh Axe Show

Fat is not the enemy — fat deficiency is. For decades, the low-fat message stripped the one macronutrient your cells use to build membranes, regulate hormones, and produce energy at the mitochondrial level. In this episode,

Dr. Axe breaks down the specific fats your body was designed to run on, which ones are silently damaging your cells, and the food-first protocol to repair the damage — starting today.

Resources mentioned: https://guide.thehealthinstitute.com/l-407

Who decides which treatments you can access—and at what cost? Ways2Well founder Brigham Buhler joins Dr. Josh Axe to discuss pharmacy benefit managers, prescription pricing, and his fight for peptide access. They explore his FDA testimony, the debate over BPC-157 and GLP-1 medications, and his clinic’s use of plasma exchange and ozone therapy.

Could ancient foods hold clues to better health and a longer life? Dr. Josh Axe explores 10 superfoods found in Scripture and the modern research behind their potential benefits for heart health, brain function, and longevity. With Bible verses, study findings, and practical guidance on how much to eat, this episode turns ancient wisdom into a grocery list you can use today.

Resources mentioned:

https://guide.thehealthinstitute.com/l-398

Lysa TerKeurst joins Dr. Josh Axe to share her journey through betrayal, emergency surgery and breast cancer—and the emotional and spiritual healing that followed. Together, they explore the connection between emotional trauma and physical well-being, the power of forgiveness, setting healthy boundaries and finding peace when life feels beyond your control.

Exhausted in the morning but wired at night? Dr. Josh Axe explores how stress and disrupted cortisol rhythms may affect your energy, sleep, and hormones. He ranks seven strategies to support a healthier rhythm, discusses herbs studied for stress support, and shares the weekly habit he values more than any supplement.

**Resources mentioned:** - Free PDF — Balance Your Hormones Naturally: https://guide.thehealthinstitute.com/l-397

Dr. Josh Axe joins Dr. Will Cole to reveal how a stem-cell treatment led to a life-threatening spinal infection—and the protocol that helped him recover. They explore hyperbaric oxygen therapy, peptides, GLP-1 drugs, adaptogens, stem-cell safety, grief and the science of extending healthspan.

Your body makes its own master antioxidant — but after 40, production drops every year and most people never know it's low until something breaks. Dr. Axe walks through the clinical evidence, the exact blood marker hiding on your last lab panel, and a 4-step protocol to rebuild glutathione at the cellular level — without expensive IVs.

Resources Mentioned:

https://guide.thehealthinstitute.com/l-390

Dr. Gez Agolli has spent nearly 30 years using integrative medicine to treat cancer, autoimmune disease, and chronic illness — and what he's found challenges almost everything conventional medicine teaches about healing. Josh calls him one of his top two mentors in functional medicine, and this conversation covers the full protocol: terrain, toxicity, advanced therapies, and why testing matters more than guessing.

Your hormones, your sleep, your stress, your diet — they may all be affecting your health at a much deeper level than you realize. Dr. Josh Axe sits down with functional medicine expert Dr. Will Cole and fitness and biohacking educator Dylan Gemelli for a no-holds-barred roundtable on what may actually be driving chronic disease, accelerated aging, hormonal dysfunction, and poor metabolic health — and why healing may need to start at the cellular level. In this episode, we learn why Dr. Axe and Dr. Cole believe cellular health could change how we approach chronic disease — and how to identify which systems in your body may be aging faster than others.

Disclaimer: The bloodwork our team runs at mybloodwork.com covers a handful of the biomarkers listed in the guide above — including critical thyroid and metabolic markers — plus a 1-hour consultation with a Senior Health Advisor, but does NOT cover all 25. You will want to consult your primary or functional doctor for the entire list.

Thank you to our sponsors!

Sunlighten Sauna → https://get.sunlighten.com/axepodcast

Manukora Manuka Honey → https://manukora.com/axe

Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube → https://www.youtube.com/@drjoshaxe?sub_confirmation=1

🎧 **Early Access!**

Our listeners enjoy every episode before anyone else!

Tune in below and join our exclusive group of listeners → Spotify → https://bit.ly/DrJoshAxeSpotify

Apple Podcasts → https://apple.co/3JDvWcS

Order our NEW BOOK, *Heal Your Cells* → healyourcellsbook.com

Watch my free training on how to naturally balance your blood sugar and reverse your symptoms → http://DrAxeDiabetesClass.com

Discover practical steps you can take today to start healing your thyroid naturally → http://DrAxeThyroidClass.com

If you’re ready to start feeling like yourself again and balance your hormones, take my free class → http://DrAxeHormoneClass.com

CONNECT WITH DR. JOSH AXE

Instagram → https://www.instagram.com/drjoshaxe/

Facebook → https://www.facebook.com/DrJoshAxe/

TikTok → https://www.tiktok.com/@thedrjoshaxeshow/

X → https://x.com/drjoshaxe/

LinkedIn → https://www.linkedin.com/in/joshaxe

Website → http://thehealthinstitute.com

Sign up for my newsletter → https://bit.ly/4oE9Jf3

Ask Dr. Axe → http://speakpipe.com/drjoshaxe

CONNECT WITH DR. WILL COLE

Website → https://drwillcole.com

Instagram → https://www.instagram.com/drwillcole/

Podcast → The Art of Being Well

CONNECT WITH DYLAN GEMELLI

Website → https://dylangemelli.com

Instagram → https://www.instagram.com/dylangemelli/

YouTube → https://www.youtube.com/@DylanGemelliBiohacking

Podcast → The Dylan Gemelli Podcast

TIMESTAMPS:

00:00 — The Biggest Drivers of Chronic Disease

02:29 — Welcome to the Health & Longevity Roundtable

03:07 — Why Cellular Health May Be the Future of Medicine

06:10 — Is One of Your Organs Aging Faster Than the Rest?

08:22 — How Early Do Health Problems Really Begin?

12:30 — The Blood Markers That Could Reveal Heart Disease Risk

18:12 — What Insulin Resistance Actually Means

19:59 — The 2 Hormones That Can Throw Everything Off

22:58 — The Surprising Connection Between Sleep & Insulin Resistance 25:10 — “I’ll Sleep When I’m Dead” Is Destroying Your Health

31:32 — Waking Up at 3 A.M.? Cortisol May Be the Reason

32:43 — How to Lower Stress & Support Your Vagus Nerve

37:18 — How Your Mind & Nervous System Affect Your Health

41:32 — Can Childhood Trauma Keep You From Healing?

43:55 — Forgiveness, Faith & the Nervous System

48:11 — Why Dylan Believes Health Starts With “Mind, Body & God”

51:11 — Can Faith Actually Help You Live Longer?

58:35 — The Truth About Peptides & Where Medicine Is Headed

1:03:29 — Are Peptides Overhyped or the Future of Health?

1:05:31 — Conventional vs. Functional Medicine

1:10:14 — How to Increase Your Healthspan, Not Just Your Lifespan

1:11:01 — Why Gut Health Matters for Longevity

1:12:46 — The Best Exercise for Mitochondria & Healthy Aging

1:16:23 — Why Women Shouldn't Be Afraid of Strength Training

1:19:32 — Keto, Carnivore & Vegan: Why Extreme Diets Can Backfire

1:21:29 — Bio-Individuality: There Is No Perfect Diet for Everyone

1:27:30 — Is Health Advice Actually Making People More Stressed?

1:29:03 — Seed Oils vs. Saturated Fat: What's Actually Healthier?

1:39:12 — The 5 Foods Josh Axe & Will Cole Would Choose for Life

1:43:11 — Josh & Will Reveal Their Favorite Cheat Foods

1:45:29 — Are We Eating Too Much Protein?

1:50:01 — Do You Really Need Fiber?

1:55:12 — The #1 Health Lesson From Josh, Will & Dylan

1:57:16 — Dylan's Final Message: God First, Health Second

After 40, your biology rewrites the rules — and most people are still playing the old game. In this episode, Dr. Josh Axe breaks down the 7 mistakes that accelerate aging, why the scale is an outdated marker, and what a study of 140,000 people across 17 countries says actually predicts how long you'll live.

In this episode:

- Why muscle loss after 40 is silent, slow, and almost always preventable — and the two-day-a-week fix that reverses it

- The grip strength finding from 140,000 adults that predicts mortality better than blood pressure or cholesterol

- Why GLP-1s and aggressive dieting without strength training leave you metabolically weaker, not stronger

- The blood markers most doctors skip — fasting insulin, ApoB, and high-sensitivity CRP — and why "normal" isn't the same as optimal

- How poor sleep and social isolation are quietly compounding every other health mistake you're making

- Josh's personal protocol after recovering from a spinal infection at 41 — and what his 76-year-old water-skiing father proves is possible

Grab our free guide for the Bloodwork Markers that Matter Most: https://bit.ly/draxe25bloodworkmarkers

Uncover what’s really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism— plus a 1-hour consultation with a Senior Health Advisor! →  http://mybloodwork.com

*Disclaimer: The bloodwork our team runs at mybloodwork.com covers a handful of the biomarkers listed in the guide above — including critical thyroid and metabolic markers — plus a 1-hour consultation with a Senior Health Advisor, but does NOT cover all 25. You will want to consult your primary or functional doctor for the entire list.

Thank you to our sponsors!

Sunlighten Sauna: https://get.sunlighten.com/axepodcast

Manukora Manuka Honey: https://manukora.com/axe

Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1

🎧 Early Access!

Our listeners enjoy every episode before anyone else! Tune in below and join our exclusive group of listeners →

Spotify: https://bit.ly/DrJoshAxeSpotify

Apple Podcast: https://apple.co/3JDvWcS

Pre-order my NEW BOOK, Heal Your Cells → healyourcellsbook.com

Watch my free training on how to naturally balance your blood sugar and reverse your symptoms → http://DrAxeDiabetesClass.com

Discover practical steps you can take today to start healing your thyroid naturally →   http://DrAxeThyroidClass.com

If you’re ready to start feeling like yourself again and balance your hormones, take my free class → http://DrAxeHormoneClass.com

CONNECT WITH DR. JOSH AXE

Instagram → https://www.instagram.com/drjoshaxe/

Facebook → https://www.facebook.com/DrJoshAxe/

TikTok → https://www.tiktok.com/@thedrjoshaxeshow/

X → https://x.com/drjoshaxe/

LinkedIn → https://www.linkedin.com/in/joshaxe

Website →  http://thehealthinstitute.com

Sign up for my newsletter → https://bit.ly/4oE9Jf3

Ask Dr. Axe → http://speakpipe.com/drjoshaxe 

0:00 Introduction

1:28 What changes in your body after 40

5:35 Josh's recovery story and what it taught him

5:41 The grip strength study (140,000 people, 17 countries)

12:43 Mistake #1 — All cardio, no strength training

17:13 Mistake #3 — Poor sleep and light exposure

21:23 Mistake #4 — Not measuring real fitness

23:53 Mistake #5 — Chasing the scale instead of muscle

25:59 Mistake #6 — Flying blind on your blood work

25:59 Mistake #7 — Missing community and social connection

37:22 The fixes: compound lifts, protein anchoring, and sleep

41:11 Home tests to check your fitness this week

DISCLAIMER

This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

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