This Week In Medicine

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New England Journal of Medicine

Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity

Cagrilintide–Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes

A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline

  Journal of  American Medical Association

 Dalbavancin for Treatment of Staphylococcus aureus Bacteremia

 Annals of Internal Medicine

Geographic Variation in Receipt of Care by Specialized Oncologists

 British Medical Journal

Global, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic

  Lancet

Extending the duration of endocrine treatment for early breast cancer: patient-level meta-analysis of 12 randomised trials of aromatase inhibitors in 22 031 postmenopausal women already treated with at least 5 years of endocrine therapy

 JAMA oncology 

Integrating Quality of Life and Survival in Systemic Therapy for Advanced Hepatocellular CarcinomaA Network Meta-Analysis

  Clinical Gastroenterology

Noninvasive Disease Assessment in Eosinophilic Esophagitis With Fractionated Exhaled Nitric Oxide, Blood, and Fecal Biomarkers

  Clinical Infectious Diseases

  Journal of Clinical Rheumatology 

Validation of the ANCA-Associated Vasculitis Patient-Reported Outcomes Questionnaire in a Latin American Vasculitis Cohort

  Circulation

Association of Smoking Cannabis With Cardiovascular Events Among Veterans With Coronary Artery Disease

 Journals of the American College of Cardiology

Recurrent Events Analysis of MASTER DAPT: Total Ischemic and Bleeding Events After Abbreviated vs Prolonged DAPT in HBR Patients

  JAMA Cardiology

Early Childhood Food Insecurity and Cardiovascular Health in Young Adulthood

  Journal of Clinical Endocrinology & Metabolism

Trends in Osteoporosis Drug Therapy Receipt Among Commercial and Medicare Advantage Enrollees in the United States, 2011-2022

 Diabetes care

Lack of Validity of the Glucose Management Indicator in Type 1 Diabetes in Pregnancy 

 Neurology

Real-World Evidence of Brexpiprazole Use and 6-Month Mortality, Hospitalization, and Emergency Department Visits Among Persons With Dementia

 Chest

Continuous Glucose Monitoring for Hyperglycemia in Critically Ill Patients

A Randomized Controlled Trial

 The American Journal of Respiratory and Critical Care Medicine

Endotypes of Pseudomonas aeruginosa Infection in Bronchiectasis Are Associated with Inhaled Antibiotic Response: Results from Two Randomized, Double-Blind, Placebo-controlled Phase III Trials (ORBIT 3 and ORBIT 4)

 Clinical Journal of American Society of Nephrology

Core Outcome Measure for Life Participation in Patients with CKD: Standardized Outcomes in Nephrology Workshops Report

Frailty in Adults with CKD and Validation of the Kidney Failure Risk Equation in Frailty Subgroups

 Kidney International reports

A Systematic Review of Treatment for Acute Interstitial Nephritis

Double-Icodextrin Dose Randomized Controlled Trial of a Double Icodextrin Dose for Older Patients on Incremental Continuous Ambulatory Peritoneal Dialysis

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First we will be discussing articles in New England Journal of Medicine

Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes

Ciprofloxacin versus Aminoglycoside–Ciprofloxacin for Bubonic Plague

Vepdegestrant, a PROTAC Estrogen Receptor Degrader, in Advanced Breast Cancer

First-Line Camizestrant for Emerging ESR1-Mutated Advanced Breast Cancer

 Journal of  American Medical Association

Alteplase for Acute Ischemic Stroke at 4.5 to 24 Hours

  Annals of Internal Medicine

Efficacy of a Very-Low-Calorie Weight Loss Diet Plus Exercise Compared With Exercise Alone on Hip Osteoarthritis Pain: A Randomized Controlled Trial

  JAMA oncology 

Modeling Population-Level Impacts of Cell-Free DNA Screening for Colorectal Cancer in Canada

  Journal of Clinical Oncology

Randomized Phase II Study of Concurrent Versus Sequential Pembrolizumab in Combination With Chemoradiation in Locally Advanced Head and Neck Cancer

 journal of Hepatology

A phase IIb randomised-controlled trial of the FFAR1/FFAR4 agonist icosabutate in MASH

   Gastroenterology

Risk of Gastric Adenocarcinoma After Eradication of Helicobacter pylori

 Clinical Gastroenterology

 Lymphocytic Esophagitis: A Histologic Pattern of Various Underlying Disorders

 Clinical Infectious Diseases

Target Trial Emulation of SARS-CoV-2 Infection Versus No Infection and Risk of Post–COVID-19 Conditions in the Omicron Variant Versus Prior Eras

  Rheumatology 

Peripheral Biomarker Signatures in Rheumatoid Arthritis–Associated Interstitial Lung Disease

  Circulation

Abelacimab Versus Rivaroxaban in Patients With Atrial Fibrillation on Antiplatelet Therapy: A Prespecified Analysis of the AZALEA-TIMI 71 Trial

  Journals of the American College of Cardiology

Using Compression Stockings to Prevent Recurrence of Vasovagal Syncope: A Randomized Sham-Controlled Trial

 JAMA Cardiology

Cumulative Life’s Essential 8 Scores and Cardiovascular Disease Risk

  Journal of Clinical Endocrinology & Metabolism

Trends in Osteoporosis Drug Therapy Receipt Among Commercial and Medicare Advantage Enrollees in the United States, 2011-2022

 Diabetes care

Lack of Validity of the Glucose Management Indicator in Type 1 Diabetes in Pregnancy

  Neurology

Statin Initiation and Dementia Incidence in a Large Health Care System From 1997 to 2020: A Target Trial Emulation Study

 The American Journal of Respiratory and Critical Care Medicine

Endotypes of Pseudomonas aeruginosa Infection in Bronchiectasis Are Associated with Inhaled Antibiotic Response: Results from Two Randomized, Double-Blind, Placebo-controlled Phase III Trials (ORBIT 3 and ORBIT 4)

 Clinical Journal of American Society of Nephrology

Sodium-Glucose Cotransporter-2 Inhibitor Therapy and Longitudinal Changes in Kidney Function among Veterans with Autosomal Dominant Polycystic Kidney Disease

Here are the  articles   from Kidney International reports

A Systematic Review of Treatment for Acute Interstitial Nephritis

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 New England Journal of Medicine

Measurable Residual Disease–Guided Therapy in Newly Diagnosed Myeloma

A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery

 Journal of  American Medical Association

Impact of the MISSION Act on Quality and Outcomes of Major Cardiovascular Procedures in Veterans

 Annals of Internal Medicine

Social Determinants of Health and Long COVID

  British Medical Journal

Sex related differences in efficacy and safety of antithrombotic therapy in patients with coronary artery disease

  Lancet

Adjuvant chemotherapy and hormonotherapy versus adjuvant hormonotherapy alone for women aged 70 years and older with high-risk breast cancer based on the genomic grade index (ASTER 70s): a randomised phase 3 trial

 JAMA oncology 

First-Line Therapy For Advanced Non–Clear Cell Renal Cell CarcinomaA Systematic Review and Meta-Analysis

 journal of Hepatology

Carvedilol vs. propranolol for the prevention of decompensation and mortality in patients with compensated and decompensated cirrhosis

 Gastroenterology

Mebeverine and the Influence of Labeling in Adolescents With Irritable Bowel Syndrome or Functional Abdominal Pain Not Otherwise Specified: A 2 × 2 Randomized, Placebo-Controlled Trial

 Clinical Gastroenterology

 Association Between the Inflammatory Potential of Diet and Constipation Among Adults in the United States: A Cross-sectional Study

  Circulation

Nonculprit Vulnerable Plaques and Prognosis in Myocardial Infarction With Versus Without ST-Segment Elevation: A PROSPECT II Substudy

 Journals of the American College of Cardiology

10-Year Outcome of Complete or Infarct Artery-Only Revascularization in STEMI With Multivessel Disease: The DANAMI-3-PRIMULTI Study

 JAMA Cardiology

Mode of Death in Patients With Heart Failure With Mildly Reduced or Preserved Ejection FractionThe FINEARTS-HF Randomized Clinical Trial

 Journal of Clinical Endocrinology & Metabolism

Tumor Volume Doubling Time of Less Than 1 Year Is Associated With a Higher Risk of Death From Medullary Thyroid Cancer

 Diabetes care

Associations of AMH in Midreproductive Years with Bone Mineral Density and Turnover Markers in Midlife

 Neurology

Risk of Ventricular Arrhythmia and Sudden Cardiac Arrest Among Older Patients Using Lamotrigine for Epilepsy

 Chest

Trajectories of Interferon-Gamma Release Assay Results Over 2 Years in Independent Cohorts From China, South Africa, Tanzania, and the United States

 The American Journal of Respiratory and Critical Care Medicine

Iloprost for the Treatment of Severe Septic Shock with Persistent Hypoperfusion: A Double-Blind, Randomized Controlled Trial

  Clinical Journal of American Society of Nephrology

Decision Readiness and Determinants of KRT among Veterans with Advanced CKD

  Kidney International reports

Low Energy Diets for Obesity and CKD (SLOW-CKD Randomized Feasibility Study)

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First we will be discussing articles in New England Journal of Medicine

Weekly Fixed-Dose Insulin Efsitora in Type 2 Diabetes without Previous Insulin Therapy

Trastuzumab Deruxtecan or Ramucirumab plus Paclitaxel in Gastric Cancer

Tarlatamab in Small-Cell Lung Cancer after Platinum-Based Chemotherapy

Ivermectin to Control Malaria — A Cluster-Randomized Trial

 Journal of  American Medical Association

Telehealth and Online Cognitive Behavioral Therapy for Chronic Pain

 Annals of Internal Medicine

Glucagon-Like Peptide-1 Receptor Agonists and Incidence of Dementia Among Older Adults With Type 2 Diabetes

  British Medical Journal

Global, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic

  JAMA oncology 

Nivolumab and Ipilimumab Combination Treatment in Advanced Ovarian and Endometrial Clear Cell CancersA Nonrandomized Clinical Trial

  journal of Hepatology

All-cause and cause-specific mortality in patients with chronic hepatitis B and concurrent steatotic liver disease

 Gastroenterology

Capsule Endoscopy–Guided Proactive Treat-to-Target Versus Continued Standard Care in Patients With Quiescent Crohn’s Disease: A Randomized Controlled Trial

 Clinical Gastroenterology

 Real-world Clinical Effectiveness and Safety of Vedolizumab and Adalimumab in Biologic-naive Patients With Crohn’s Disease: Results From the EVOLVE Study

  Circulation

Efficacy and Safety of Inclisiran in Adolescents With Genetically Confirmed Homozygous Familial Hypercholesterolemia: Results From the Double-Blind, Placebo-Controlled Part of the ORION-13 Randomized Trial

  Journals of the American College of Cardiology

Biolimus-Eluting Biomatrix Stent vs a Dual-Therapy Sirolimus-Eluting Stent in PCI: The SORT OUT XI Randomized Trial

 JAMA Cardiology

OCT vs Angiography for Guidance of Percutaneous Coronary Intervention of Calcified LesionsThe CALIPSO Randomized Clinical Trial

  Journal of Clinical Endocrinology & Metabolism

The Role of Whole Food Plant-Based Food Intake on Postprandial Glycemia in Type 1 Diabetes

 Diabetes care

Associations of Concurrent Hypertension and Type 2 Diabetes With Mortality Outcomes: A Prospective Study of U.S. Adults

  Chest

Clinical Remission Over 2 Years With Benralizumab in Severe Eosinophilic Asthma

 The American Journal of Respiratory and Critical Care Medicine

Deep Learning Estimation of Small Airway Disease from Inspiratory Chest Computed Tomography: Clinical Validation, Repeatability, and Associations with Adverse Clinical Outcomes in Chronic Obstructive Pulmonary Disease

  Clinical Journal of American Society of Nephrology

Unveiling the Causal Relationship between Thyroid and Kidney Function: A Multivariable Mendelian Randomization

Here are the  articles   from Kidney International reports

Characterization of Monogenic Kidney Disease in Older Patients With CKD

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New England Journal of Medicine

Perioperative Durvalumab in Gastric and Gastroesophageal Junction Cancer

First-Line Treatment of Pulmonary Sarcoidosis with Prednisone or Methotrexate

Graft-versus-Host Disease Prophylaxis with Cyclophosphamide and Cyclosporin

  Journal of  American Medical Association

Hepatitis C Screening in Emergency Departments

The DETECT Hep C Randomized Clinical Trial

 Annals of Internal Medicine

Vaporized Nicotine Products for Smoking Cessation Among

  British Medical Journal

Global, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic

 Lancet

Safety, tolerability, pharmacokinetics, and pharmacodynamics of the first-in-class GLP-1 and amylin receptor agonist, amycretin: a first-in-human, phase 1, double-blind, randomised, placebo-controlled trial

  Journal of Clinical Oncology

Acalabrutinib Plus Bendamustine-Rituximab in Untreated Mantle Cell Lymphoma

  Gastroenterology

Electroacupuncture Reduces Duration of Postoperative Ileus After Laparoscopic Gastrectomy for Gastric Cancer: A Multicenter Randomized Trial

 Clinical Gastroenterology

Budesonide Versus Mesalamine in Microscopic Colitis: A Comparative Meta-analysis of Randomized Controlled Trials

  Circulation

Pulsed Field Ablation of Persistent Atrial Fibrillation With Continuous Electrocardiographic Monitoring Follow-Up: ADVANTAGE AF Phase 2

 Journals of the American College of Cardiology

Impact of Optical Coherence Tomography-Based Post-PCI Physiology Assessment to Predict Clinical Outcomes: An ILUMIEN-IV Substudy

  JAMA Cardiology

Emergency Department–Based Education and mHealth Empowerment Intervention for HypertensionThe TOUCHED Randomized Clinical Trial

 Journal of Clinical Endocrinology & Metabolism

Clomiphene Citrate Medication for Infertility and Risk of Stillbirth or Neonatal Death: A Population-based Cohort Study 

 Diabetes care

Comparison of Serum Creatinine– and Cystatin C–Based eGFR at Baseline and Their Prediction of Incident Moderate Albuminuria in Individuals With Type 1 Diabetes 

  Neurology

Lamotrigine and Cardiac Arrhythmias: A Target Trial Approach

 Chest

Modified Cuff Leak Test for Predicting the Risk of Reintubation in Patients With Invasive Mechanical Ventilation

mThe American Journal of Respiratory and Critical Care Medicine

Airway Scaffolds for Emphysema-related Hyperinflation: Six-Month Results from the BREATHE Trial

 Clinical Journal of American Society of Nephrology

The Emerging Nephrology Physician Workforce in the United States: Defining an Impending Shortfall

 Kidney International reports

Point-of-Care Testing and Integrated Digital Health Technology for CKD Screening in High-Risk Populations of India

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 New England Journal of Medicine

 As-Needed Albuterol–Budesonide in Mild Asthma

Global Effect of Cardiovascular Risk Factors on Lifetime Estimates

Intravenous Tenecteplase before Thrombectomy in Stroke

Overall Survival with Inavolisib in PIK3CA-Mutated Advanced Breast Cancer

Journal of  American Medical Association

Obesity Variation Among Asian, Native Hawaiian or Pacific Islander Adults in the US

Annals of Internal Medicine

Development and Validation of Body Mass Index–Specific Waist Circumference Thresholds in Postmenopausal Women

 British Medical Journal

Global, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic

 Lancet

Mitapivat in adults with non-transfusion-dependent α-thalassaemia or β-thalassaemia (ENERGIZE): a phase 3, international, randomised, double-blind, placebo-controlled trial

  JAMA oncology 

Adjuvant Chemoradiation and Immunotherapy for Extrahepatic Cholangiocarcinoma and Gallbladder CancerA Randomized Clinical Trial

 Journal of Clinical Oncology

Use of Low-Value Cancer Treatments in Medicare Advantage Versus Traditional Medicare

journal of Hepatology

Modeling the health and economic impact of pharmacologic therapies for MASLD in the United States

  Gastroenterology

Diagnostic Accuracy of Timed Barium Esophagram for Achalasia

  Clinical Gastroenterology

 Lymphocytic Esophagitis: A Histologic Pattern of Various Underlying Disorders

  Rheumatology 

Association of Soluble Immune Checkpoint Molecules PD1 and 4-1BB With CTLA-4Ig Treatment Response in Early Rheumatoid Arthritis

 Circulation

 Burden of Cardiovascular Outcomes After SARS-CoV-2 Infection in South Korea and Japan: A Binational Population-Based Cohort Study

 Journals of the American College of Cardiology

Plaque Vulnerability and Cardiovascular Risk Factor Burden in Acute Coronary Syndrome: An Optical Coherence Tomography Analysis

  JAMA Cardiology

Cumulative Life’s Essential 8 Scores and Cardiovascular Disease Risk

 Journal of Clinical Endocrinology & Metabolism

Effects of a Carbohydrate-Restricted Diet on β-Cell Response in Adults With Type 2 Diabetes

 Diabetes care

Economic Costs Attributed to Diagnosed Diabetes in Each U.S. State and the District of Columbia: 2021

 Neurology

Neighborhood Socioeconomic Status and the Functional Outcome of Patients Treated With Endovascular Thrombectomy for Ischemic Stroke

  Chest

Prolonged Mechanical Ventilation in Critically Ill Patients

 he American Journal of Respiratory and Critical Care Medicine

Prevention of Cardiovascular and Other Systemic Adverse Outcomes in Patients with Asthma Treated with Biologics

Clinical Journal of American Society of Nephrology

High Heat Exposure and Medical Utilization among the CKD Population

Kidney International reports

Holistic Impact of CKD: A Clinical, Economic, and Environmental Analysis by IMPACT CKD

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 New England Journal of Medicine

Structured Exercise after Adjuvant Chemotherapy for Colon Cancer

Tirzepatide as Compared with Semaglutide for the Treatment of Obesity

Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer

  Journal of  American Medical Association

Lorundrostat in Participants With Uncontrolled Hypertension and Treatment-Resistant Hypertension: The Launch-HTN Randomized Clinical Trial

 Annals of Internal Medicine

Risk for Stroke After Newly Diagnosed Atrial Fibrillation During Hospitalization for Other Primary Diagnoses

A Retrospective Cohort Study

  British Medical Journal

Global, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic

  Lancet

Surgery versus corticosteroid injection for carpal tunnel syndrome (DISTRICTS): an open-label, multicentre, randomised controlled trial

  Gastroenterology

Noncontrast Magnetic Resonance Imaging vs Ultrasonography for Hepatocellular Carcinoma Surveillance: A Randomized, Single-Center Trial

  Clinical Gastroenterology

 Esophageal Expert Development of a Preliminary Question Prompt List for Adults With Eosinophilic Esophagitis: A Modified Delphi Study

  Clinical Infectious Diseases

Glucocorticoid Dosing and Implications for Vaccination: Evolution of Global Definitions

 Journal of Clinical Rheumatology 

Association of Klotho and Gout in Middle-Aged and Older Adults: National Health and Nutrition Survey (2007–2016)

  Circulation

FMO2 Prevents Pathological Cardiac Hypertrophy by Maintaining the ER-Mitochondria Association Through Interaction With IP3R2-Grp75-VDAC1

  Journals of the American College of Cardiology

Long-Acting Factor XI Inhibition and Periprocedural Bleeding: An Analysis From AZALEA-TIMI 71

  JAMA Cardiology

Cardiomyopathy-Associated Gene Variants in Atrial Fibrillation

 Journal of Clinical Endocrinology & Metabolism

Cost-effectiveness Analysis Comparing Conventional and Digital Software Supported Management for Hypothyroidism

 Diabetes care

Impact of Islet Transplantation on Diabetes Complications and Mortality in Patients Living With Type 1 Diabetes

 Neurology

Association of Predicted Visceral Fat Percentage With Dementia Risk in Older Adults: The Role of Genetic Risk and Lifestyle

 Chest

Ventilator-Associated Pneumonia in Low- and Middle-Income vs High-Income Countries

 The American Journal of Respiratory and Critical Care Medicine

Early versus Delayed Switching from Controlled to Assisted Ventilation: A Target Trial Emulation

 Clinical Journal of American Society of Nephrology

High Heat Exposure and Medical Utilization among the CKD Population

 Kidney International reports

Effect of Sleep Characteristics on Rapid Estimated GFR Decline in Adults with Normal Kidney Function

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 New England Journal of Medicine

Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation

Efruxifermin in Compensated Liver Cirrhosis Caused by MASH

Journal of  American Medical Association

Complete AI-Enabled Echocardiography Interpretation With Multitask Deep Learning

Annals of Internal Medicine

Risk for Stroke After Newly Diagnosed Atrial Fibrillation During Hospitalization for Other Primary Diagnoses

British Medical Journal

Effect of UK Quality and Outcomes Framework pay-for-performance programme on quality of primary care

journal of Hepatology

Histological severity, clinical outcomes and impact of antiviral treatment in indeterminate phase of chronic hepatitis B: A systematic review and meta-analysis

Clinical Gastroenterology

The Tissue Systems Pathology Test Objectively Risk-Stratifies Patients With Barrett’s Esophagus: Results From a Multicenter US Clinical Experience Study

Delayed Perforation After Endoscopic Resection of Upper Gastrointestinal Tumors: CT Findings to Identify Patients Requiring Surgery

Clinical Infectious Diseases

Antimicrobial Stewardship and Beyond: The Many Essential Roles of Infectious Diseases Pharmacists

  Circulation

Lymphatic Endothelial Branched-Chain Amino Acid Catabolic Defects Undermine Cardiac Lymphatic Integrity and Drive HFpEF

 Journals of the American College of Cardiology

Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension:

  JAMA Cardiology

Asundexian or Apixaban in Patients With Atrial Fibrillation According to Prior Oral Anticoagulant UseA Subgroup Analysis of the OCEANIC-AF Randomized Clinical Trial

 Journal of Clinical Endocrinology & Metabolism

Decreased Neutrophils Are Associated With Reduced Risk of Type 2 Diabetes Incidence

 Diabetes care

Cellular Versus Acellular Matrix Products for Diabetic Foot Ulcer Treatment: The Dermagraft and Oasis Longitudinal Comparative Efficacy Study (DOLCE)—A Randomized Clinical Trial 

Neurology

Noninvasive Assessment of the Risk Features of Hemorrhage in Moyamoya Disease Using 7T MRI

 Chest

Preserved Ratio Impaired Spirometry Prevalence, Risk Factors, and Outcomes

 The American Journal of Respiratory and Critical Care Medicine

Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome

 Clinical Journal of American Society of Nephrology

Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Patients with and without Advanced CKD: Systematic Review and Meta-Analysis

Kidney International reports

Dotinurad Treatment for Patients With Hyperuricemia Complicating CKD

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New England Journal of Medicine

Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis

Navigational Bronchoscopy or Transthoracic Needle Biopsy for Lung Nodules

Omitting Regional Nodal Irradiation after Response to Neoadjuvant Chemotherapy

A Trial of Trimethoprim–Sulfamethoxazole in Pregnancy to Improve Birth Outcomes

  Journal of  American Medical Association

Clinical Validation of a Circulating Tumor DNA–Based Blood Test to Screen for Colorectal Cancer

 Annals of Internal Medicine

Effects of a Hypotension-Avoidance Versus a Hypertension-Avoidance Strategy on Neurocognitive Outcomes After Noncardiac Surgery

  Lancet

Comparison of supplemental breast cancer imaging techniques—interim results from the BRAID randomised controlled trial

  Journal of Clinical Oncology

Explaining the Relationships Between Age, Endocrine Therapy Persistence, and Risk of Recurrence in Hormone Receptor–Positive Early Breast Cancer: A Nationwide Cohort Study

  journal of Hepatology

Utility of AI digital pathology as an aid for pathologists scoring fibrosis in MASH

   Gastroenterology

Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease

  Clinical Gastroenterology

The Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation

 Clinical Infectious Diseases

Association Between Delayed Broad-Spectrum Gram-negative Antibiotics and Clinical Outcomes

 Rheumatology 

Prevalence of Frailty and Associated Factors in a US-Wide Cohort of Rheumatic Diseases

  Journals of the American College of Cardiology

Disentangling the Impact of Adiposity From Insulin Resistance in Heart Failure With Preserved Ejection Fraction

  JAMA Cardiology

Sex-Specific Association of Myocardial Fibrosis With Mortality in Patients With Aortic Stenosis

  Diabetes care

Cardiovascular and Kidney Outcomes and Mortality With Long-Acting Injectable and Oral Glucagon-Like Peptide 1 Receptor Agonists in Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Trials 

  Neurology

Association of Nonmodifiable Risk Factors With Alzheimer Disease Blood Biomarkers in Community-Dwelling Adults in the ESTHER Study

  Chest

Clinical Efficacy of Serum Antiglycopeptidolipid Core IgA Antibody Test for Screening Nontuberculous Mycobacterial Pulmonary Disease in Bronchiectasis

 The American Journal of Respiratory and Critical Care Medicine

Impact of the CAPTURE Chronic Obstructive Pulmonary Disease Screening Tool in U.S. Primary Care: A Cluster-Randomized Trial

  Clinical Journal of American Society of Nephrology

Clinical Implications of Slope of GFR in Clinical Trials of CKD Progression

 Kidney International reports

Nephrotic Syndrome Thromboprophylaxis With Direct Oral Anticoagulants or Vitamin K Antagonists

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 New England Journal of Medicine

Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death

Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes

A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis

 Journal of  American Medical Association

 Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension

The KARDIA-2 Randomized Clinical Trial

Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients

The A2B Randomized Clinical Trial

 Annals of Internal Medicine

Trends in Utilization of Glucose- and Weight-Lowering Medications After Tirzepatide Approval in the United States

  British Medical Journal

A village doctor-led mobile health intervention for cardiovascular risk reduction in rural China

  Lancet

Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial

 journal of Hepatology

Utility of AI digital pathology as an aid for pathologists scoring fibrosis in MASH

 Gastroenterology

Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease

 Clinical Gastroenterology

The Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation

 Rheumatology 

Exploring the Association of Sociodemographic Factors and Primary Diagnosis With Transition Readiness in Adolescents With Rheumatic Disease

 Journal of Clinical Rheumatology 

Association of Patient Sex With Inpatient Mortality After Elective Primary Total Hip Arthroplasty for Osteoarthritis

 Circulation

Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension

   Journals of the American College of Cardiology

Disentangling the Impact of Adiposity From Insulin Resistance in Heart Failure With Preserved Ejection Fraction

  JAMA Cardiology

Clinical Phenotype and Prognosis of Asymptomatic Patients With Transthyretin Cardiac Amyloid Infiltration

  Journal of Clinical Endocrinology & Metabolism

Fetal/Maternal-Determined Birth Weight and Adulthood Type 2 Diabetes and Its Subtypes: A Mendelian Randomization Study

 Neurology

Stability and Accuracy of a Diagnosis of Parkinson Disease Over 10 Years

 Chest

Video vs Direct Laryngoscopy for Tracheal Intubation After Cardiac Arrest

 The American Journal of Respiratory and Critical Care Medicine

Impact of the CAPTURE Chronic Obstructive Pulmonary Disease Screening Tool in U.S. Primary Care: A Cluster-Randomized Trial

 Clinical Journal of American Society of Nephrology

High-Diversity Plant-Based Diet and Gut Microbiome, Plasma Metabolome, and Symptoms in Adults with CKD

 Kidney International reports

Kidney Transplantation Improves Survival in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides With End-Stage Kidney Disease