This Week In Medicine

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Oveporexton, an Oral Orexin Receptor 2–Selective Agonist, in Narcolepsy Type 1

Second-Line Antiretroviral Therapy for Children Living with HIV in Africa

 Journal of  American Medical Association

Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial

A Multidimensional Diagnostic Approach for Chronic Obstructive Pulmonary Disease

 Annals of Internal Medicine

Comparison of Dose Escalation Versus Switching to Tirzepatide Among People With Type 2 Diabetes Inadequately Controlled on Lower Doses of Dulaglutide

 British Medical Journal

Effects of a general practitioner-led brief narrative exposure intervention on symptoms of post-traumatic stress disorder after intensive care (PICTURE): multicentre, observer blind, randomised controlled trial

 Lancet

Efficacy and safety of topical delgocitinib cream versus oral alitretinoin capsules in adults with severe chronic hand eczema (DELTA FORCE): a 24-week, randomised, head-to-head, phase 3 trial

  Gastroenterology

Mechanistic Implications of the Mediterranean Diet in Patients With Newly Diagnosed Crohn's Disease: Multiomic Results From a Prospective Cohort

 Clinical Gastroenterology

The Lactulose Breath Test Can Predict Refractory Gastroesophageal Reflux Disease by Measuring Bacterial Overgrowth in the Small Intestine

 Rheumatology 

A Catalog of “Knee Friendly” Aerobic Exercises Developed for Patients With Knee Osteoarthritis: An International Patient Survey

 Journal of Clinical Rheumatology 

Association of Klotho and Gout in Middle-Aged and Older Adults: National Health and Nutrition Survey (2007–2016)

  Circulation

Outcomes of Transcatheter Aortic Valve Replacement in Low-Risk Patients in the United States: A Report From the STS/ACC TVT Registry

 Journals of the American College of Cardiology

Effect of Empagliflozin on the Mechanisms Driving Erythropoiesis and Iron Mobilization in Patients With Heart Failure: The EMPEROR Program

 JAMA Cardiology

Long-Term Aspirin vs Clopidogrel After Coronary Stenting by Bleeding Risk and Procedural Complexity

 Journal of Clinical Endocrinology & Metabolism

Risk of Type 2 Diabetes, MASLD and Cardiovascular Disease in People Living With Polycystic Ovary Syndrome

 Diabetes care

Early Fasting Serum Glucose or Weight Reduction With Tirzepatide and Metabolic Outcomes in People With Type 2 Diabetes: A Post Hoc Analysis of the SURPASS Trials

 Neurology

Risk of False Acetylcholine Receptor Autoantibody Positivity by Radioimmunoprecipitation Assay in Clinical Practice

 Chest

Low-Dose Melatonin for Prevention of Delirium in Critically Ill Patients

 The American Journal of Respiratory and Critical Care Medicine

Population-Based Screening for Chronic Obstructive Pulmonary Disease Using the St. George’s Respiratory Questionnaire in Resource-Limited Settings

 Clinical Journal of American Society of Nephrology

Predicting Kidney Outcomes in Autosomal Dominant Polycystic Kidney Disease: A Comprehensive Biomarker Analysis

 Kidney International reports

Prospective Cohort Study in Alport Syndrome Patients Under Standard Therapy

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New England Journal of Medicine

Tolebrutinib in Nonrelapsing Secondary Progressive Multiple Sclerosis

Tolebrutinib versus Teriflunomide in Relapsing Multiple Sclerosis

 Journal of  American Medical Association

Spironolactone vs Amiloride for Resistant Hypertension

  Annals of Internal Medicine

Medical, Societal, and Ethical Considerations for Directed Blood Donation in 2025

  British Medical Journal

Use of gabapentinoid treatment and the risk of self-harm: population based self-controlled case series study

 Lancet

Clinical presentation and epidemiological assessment of confirmed human mpox cases in DR Congo: a surveillance-based observational study

  journal of Hepatology

A new generation of non-invasive tests of liver fibrosis with improved accuracy in MASLD

  Gastroenterology

Physiological Data Collected From Wearable Devices Identify and Predict Inflammatory Bowel Disease Flares

 Clinical Gastroenterology

Reproducibility of the AGREE II Tool for Assessing the Methodological Quality of Clinical Practice Guidelines for the Management of Antithrombotic Agents in Patients Undergoing GI Endoscopy

 Circulation

Genetic and Lifestyle Risks for Coronary Artery Disease and Long-Term Risk of Incident Dementia Subtypes

 Journals of the American College of Cardiology

Ischemia on Dobutamine Stress Echocardiography Predicts Efficacy of PCI: Results From the ORBITA-2 Trial

 JAMA Cardiology

Trajectory of Cardiovascular Health Across Childhood and Adolescence

 Journal of Clinical Endocrinology & Metabolism

Renal Protective Effect of Metformin in Type 2 Diabetes Patients

 Diabetes care

Efficacy and Safety of Finerenone in Type 2 Diabetes: A Pooled Analysis of Trials of Heart Failure and Chronic Kidney Disease 

  Neurology

Endovascular Thrombectomy for Large Ischemic Core Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  Chest

Effect of Flow Rates of High-Flow Nasal Cannula on Extubation Outcomes

 The American Journal of Respiratory and Critical Care Medicine

Clinical and Biological Features of a Thickened Basement Membrane Zone in Asthma 

 Clinical Journal of American Society of Nephrology

Dialysis Dependence in Standard versus Accelerated Initiation of KRT in AKI: A Post Hoc Analysis

 Kidney International reports

Scoping Review of Kidney Patients and Providers Perspectives on Disaster Management

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First we will be discussing articles in New England Journal of Medicine

Lepodisiran — A Long-Duration Small Interfering RNA Targeting Lipoprotein(a)

Identification of Hepatic-like EPO as a Cause of Polycythemia

Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1

Mepolizumab to Prevent Exacerbations of COPD with an Eosinophilic Phenotype

 Journal of  American Medical Association

Midurethral Sling vs OnabotulinumtoxinA in Females With Urinary Incontinence

The MUSA Randomized Clinical Trial

  Annals of Internal Medicine

Sexual Trauma, Suicide, and Overdose in a National Cohort of Older Veterans

 British Medical Journal

Use of gabapentinoid treatment and the risk of self-harm

  Lancet

Oral gepotidacin for the treatment of uncomplicated urogenital gonorrhoea (EAGLE-1): a phase 3 randomised, open-label, non-inferiority, multicentre study

 Journal of Clinical Oncology

Supervised Exercise for Patients With Metastatic Breast Cancer

  journal of Hepatology

Metabolic dysfunction-associated steatohepatitis reduces interferon and macrophage liver gene signatures in patients with chronic hepatitis B

 Gastroenterology

Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood

 Journal of Clinical Rheumatology 

Salivary β2-Microglobulin, Na+, and Cortisol Levels, and Salivary Glands' Uptakes in Sialoscintigraphy in Sjögren Disease

  Circulation

Nrf3-Mediated Mitochondrial Superoxide Promotes Cardiomyocyte Apoptosis and Impairs Cardiac Functions by Suppressing Pitx2

 Journals of the American College of Cardiology

Nonlinear Relation Between Cardiac Mortality and Excess Temperature in Heatwaves: Exposure Response in 2.39 Million Patients

From JAMA Cardiology

Salt Substitution and Recurrent Stroke and DeathA Randomized Clinical Trial

  Journal of Clinical Endocrinology & Metabolism

Digital Voice Analysis as a Biomarker of Acromegaly 

  Chest

Treatment of Acute Circulatory Failure Based on Carbon Dioxide-Oxygen (CO2-O2) Derived Indices

The Lactel Randomized Multicenter Study

Next we will be discussing articles In the field of Nephrology

Here are the  articles   from Kidney International reports

Improving Blood Pressure in High-Risk Patients With CKD Using an Interdisciplinary Remote Hypertension Program

Outcomes for Patients With a Deceased Donor Kidney Offer in the New Allocation System

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New England Journal of Medicine

Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis

Pulsed Field or Cryoballoon Ablation for Paroxysmal Atrial Fibrillation

Fidanacogene Elaparvovec for Hemophilia B — A Multiyear Follow-up Study

 Journal of  American Medical Association

Use of Life Support and Outcomes Among Patients Admitted to Intensive Care Units

 Annals of Internal Medicine

Patterns of U.S. Firearm Injury Emergency Department Visits by Month, Day, and Time During 2018 to 2023

 British Medical Journal

Firearm availability and firearm incidents: quasi-experimental analysis using start of US hunting seasons

  Lancet

Effect of invitation to colonoscopy versus faecal immunochemical test screening on colorectal cancer mortality (COLONPREV): a pragmatic, randomised, controlled, non-inferiority trial

 Journal of Clinical Oncology

Trastuzumab-Pertuzumab Plus Eribulin or Taxane as First-Line Chemotherapy for Human Epidermal Growth Factor 2–Positive Locally Advanced/Metastatic Breast Cancer

 journal of Hepatology

PNPLA3 rs738409, environmental factors and liver-related mortality in the US population

 Gastroenterology

ERBB2 Comprehensive Profiling and Prognostication in Stage III Colon Cancer: Findings From PETACC8 and IDEA-France Cohorts

  Clinical Gastroenterology

Histological Outcomes of Pharmacological Interventions in Eosinophilic Esophagitis for Adults and Children: A Network Meta-analysis of Randomized Controlled Trials

 Rheumatology 

Osteoclastogenesis in Patients With Systemic Sclerosis With and Without Calcinosis Cutis

  Journal of Clinical Rheumatology 

Childhood Familial Mediterranean Fever in the United States: Spectrum of Clinical Phenotypes and MEFV Genotypes in a Cohort From Southeast Michigan

  Circulation

 Differential Associations of Cigar, Pipe, and Smokeless Tobacco Use Versus Combustible Cigarette Use With Subclinical Markers of Inflammation, Thrombosis, and Atherosclerosis: The Cross-Cohort Collaboration–Tobacco Working Group

 Journals of the American College of Cardiology

Genetic Risk and First-Trimester Cardiovascular Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women

 JAMA Cardiology

Treatment Strategies to Control Blood Pressure in People With Hypertension in Tanzania and LesothoA Randomized Clinical Trial

 Journal of Clinical Endocrinology & Metabolism

Efficacy and Safety of TransCon PTH in Adults With Hypoparathyroidism: 52-Week Results From the Phase 3 PaTHway Trial

 Diabetes care

Longitudinal Associations of PFAS Exposure With Insulin Sensitivity and β-Cell Function Among Hispanic Women With a History of Gestational Diabetes Mellitus 

 Neurology

Investigating Whether Dissemination in Time Is Essential to Diagnose Relapsing Multiple Sclerosis

  Chest

Sarcoidosis Treatment Patterns in the United States

 he American Journal of Respiratory and Critical Care Medicine

Nasal High Flow to Modulate Dyspnea in Orally Intubated Patients

Kidney International reports

Randomized Trial of Lower-Dose Roxadustat Efficacy and Safety in Non–Dialysis-Dependent CKD-Associated Anemia

Open-Label, Randomized, Controlled, Crossover Trial on the Effect of Dapagliflozin in Patients With ADPKD Receiving Tolvaptan

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 New England Journal of Medicine

Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism

Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels

Endovascular Treatment of Stroke Due to Medium-Vessel Occlusion

Dapagliflozin in Patients Undergoing Transcatheter Aortic-Valve Implantation

Assessment of a Polygenic Risk Score in Screening for Prostate Cancer

  Journal of  American Medical Association

Invasive Group A Streptococcal Infections in 10 US States

 Annals of Internal Medicine

Insurer-Level Estimates of Revenue From Differential Coding in Medicare Advantage

  British Medical Journal

Evolution of reported patient and public involvement over time in randomised controlled trials in major medical journals and in their protocols

  Lancet

Effect of digital adherence technologies on treatment outcomes in people with drug-susceptible tuberculosis: four pragmatic, cluster-randomised trials

  Cancer Journal for Clinicians

Cancer statistics for African American and Black people, 2025

 Journal of Clinical Oncology

Minimal Residual Disease–Based End Point for Accelerated Assessment of Clinical Trials in Multiple Myeloma: A Pooled Analysis of Individual Patient Data From Multiple Randomized Trials

  journal of Hepatology

Association of metabolic signatures of air pollution with MASLD: Observational and Mendelian randomization study

 Gastroenterology

Glepaglutide, a Long-Acting Glucagon-like Peptide-2 Analogue, Reduces Parenteral Support in Patients With Short Bowel Syndrome: A Phase 3 Randomized Controlled Trial

 Clinical Gastroenterology

Histological Outcomes of Pharmacological Interventions in Eosinophilic Esophagitis for Adults and Children: A Network Meta-analysis of Randomized Controlled Trials

 Rheumatology 

Safety of Avacopan for the Treatment of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Combined Data From Three Clinical Trials

  Journal of Clinical Rheumatology 

Age-Related Differences Between Juvenile and Adult Autoimmune Inflammatory Myopathies

  Circulation

Evidence-Based Application of Natriuretic Peptides in the Evaluation of Chronic Heart Failure With Preserved Ejection Fraction in the Ambulatory Outpatient Setting

  Journals of the American College of Cardiology

Cardiac Troponins and Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis

  JAMA Cardiology

Default Bulk Ordering and Text Messaging to Enhance Outreach for Lipid ScreeningA Randomized Clinical Trial

 Journal of Clinical Endocrinology & Metabolism

MBX 2109, A Once-Weekly Parathyroid Hormone Replacement Therapy Prodrug: Phase 1, First-In-Human, Randomized Trial 

  Diabetes care

Diabetes Risk After Treatment for Childhood and Young Adult Cancer 

  Neurology

Neurodegeneration and Demyelination in the Multiple Sclerosis Spinal Cord: Clinical, Pathological, and 7T MRI Perspectives

  Chest

Estimation of Expiratory Function in Infants With Passive Expiration From Total Lung Capacity

  The American Journal of Respiratory and Critical Care Medicine

Temporal Exploration of Chronic Obstructive Pulmonary Disease Phenotypes: Insights from the COPDGene and SPIROMICS Cohorts

  Kidney International reports

Real-Life Data of 2-Year Lumasiran Use in the DAILY-LUMA Cohort

Systematic Review of the Effects of Iron on Cardiovascular, Kidney, and Safety Outcomes in Patients With CKD

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 New England Journal of Medicine

Twice-Yearly Lenacapavir for HIV Prevention in Men and Gender-Diverse Persons

Left Atrial Appendage Closure after Ablation for Atrial Fibrillation

Alteplase for Posterior Circulation Ischemic Stroke at 4.5 to 24 Hours

The Genetic Architecture of Congenital Diarrhea and Enteropathy

 Journal of  American Medical Association

Cardiac Arrest During Long-Distance Running Races

 Annals of Internal Medicine

The Effect of 4:3 Intermittent Fasting on Weight Loss at 12 Months: A Randomized Clinical Trial

 British Medical Journal

Effects of intensive blood pressure treatment on orthostatic hypertension

 Lancet

Pharmacokinetics and safety of once-yearly lenacapavir: a phase 1, open-label study

 Journal of Clinical Oncology

Efficacy and Safety of Denileukin Diftitox-Cxdl, an Improved Purity Formulation of Denileukin Diftitox, in Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma

  journal of Hepatology

Association of metabolic signatures of air pollution with MASLD: Observational and Mendelian randomization study

 Gastroenterology

Glepaglutide, a Long-Acting Glucagon-like Peptide-2 Analogue, Reduces Parenteral Support in Patients With Short Bowel Syndrome: A Phase 3 Randomized Controlled Trial

 Clinical Gastroenterology

Preinjection With Ligation-Assisted Endoscopic Mucosal Resection for Barrett’s Dysplasia and Early Esophageal Adenocarcinoma: Characteristic Histological Features of the Depth of Resection

   Clinical Infectious Diseases

Peer-Assisted Telemedicine for Hepatitis C in People Who Use Drugs: A Randomized Controlled Tria

  Rheumatology 

Osteoclastogenesis in Patients With Systemic Sclerosis With and Without Calcinosis Cutis

  Journal of Clinical Rheumatology 

Age-Related Differences Between Juvenile and Adult Autoimmune Inflammatory Myopathies

  Circulation

Clinical Outcomes With Normothermic Pulsatile Organ Perfusion in Heart Transplantation: A Report From the OCS Heart Perfusion Registry

  Journals of the American College of Cardiology

New Threshold for Defining Mild Aortic Stenosis Derived From Velocity-Encoded MRI in 60,000 Individuals

  JAMA Cardiology

Intravascular Sympathetic Stimulation to Facilitate Catheter Ablation of Premature Ventricular Complexes

  Journal of Clinical Endocrinology & Metabolism

MBX 2109, A Once-Weekly Parathyroid Hormone Replacement Therapy Prodrug

 Diabetes care

Diabetes Risk After Treatment for Childhood and Young Adult Cancer 

  Neurology

Associations of Plasma Neurofilament Light Levels With Brain Microstructure and Macrostructure and Cognition in the Community-Based Rhineland Study

  Chest

Implementation and Effectiveness of Guideline-Recommended Clinical Activities for Children With Asthma

 The American Journal of Respiratory and Critical Care Medicine

Temporal Exploration of Chronic Obstructive Pulmonary Disease Phenotypes: Insights from the COPDGene and SPIROMICS Cohorts

 Clinical Journal of American Society of Nephrology

Performance of Creatinine and Cystatin-Based Equations on Estimating Measured GFR in People with Hematological and Solid Cancers

  Kidney International reports

Systematic Review of the Effects of Iron on Cardiovascular, Kidney, and Safety Outcomes in Patients With CKD

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 New England Journal of Medicine

Intensive Blood-Pressure Control in Patients with Type 2 Diabetes

Inebilizumab for Treatment of IgG4-Related Disease

Tezepelumab in Adults with Severe Chronic Rhinosinusitis with Nasal Polyps

Journal of  American Medical Association

Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke

A Systematic Review and Meta-Analysis

Annals of Internal Medicine

Excess Mortality Rate in Black Children Since 1950 in the United States: A 70-Year Population-Based Study of Racial Inequalities

British Medical Journal

Effects of intensive blood pressure treatment on orthostatic hypertension: individual level meta-analysis

Lancet

Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum and Plasmodium vivax malaria, 2000–22: a spatial and temporal modelling study

journal of Hepatology

Predictors of hepatic flares after nucleos(t)ide analogue cessation – Results of a global cohort study (RETRACT-B study)

Intention-to-treat outcomes of patients with hepatocellular carcinoma receiving immunotherapy before liver transplant: The multicenter VITALITY study

Immune checkpoint inhibitors exhibit significant potential in neoadjuvant therapy  Gastroenterology

Multi-Cohort Analysis Reveals Altered Archaea in Colorectal Cancer Fecal Samples Across Populations

Clinical Gastroenterology

Treatment of the Buried Bumper Syndrome​​​​​: A Retrospective Multicenter Study With Inclusion of 160 Cases

Clinical Infectious Diseases

Peer-Assisted Telemedicine for Hepatitis C in People Who Use Drugs: A Randomized Controlled Trial

Rheumatology 

The Design of a Randomized Controlled Active Comparator Strategy Trial for Gout: Treat to Target Serum Urate Versus Treat to Avoid Symptoms

 Circulation

Activation of Imprinted Gene PW1 Promotes Cardiac Fibrosis After Ischemic Injury

=  Journals of the American College of Cardiology

Transcatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients: An Updated Meta-Analysis of Randomized Controlled Trials

 JAMA Cardiology

Intravascular Sympathetic Stimulation to Facilitate Catheter Ablation of Premature Ventricular Complexes

  Journal of Clinical Endocrinology & Metabolism

Iron Status Correlates Strongly to Insulin Resistance Among US Adults: A Nationwide Population-Based Study

Diabetes care

Three-Year Follow-up After Antiviral Treatment in New-Onset Type 1 Diabetes: Results From the Diabetes Virus Detection and Intervention Trial 

Neurology

Associations of Plasma Neurofilament Light Levels With Brain Microstructure and Macrostructure and Cognition in the Community-Based Rhineland Study

Chest

Implementation and Effectiveness of Guideline-Recommended Clinical Activities for Children With Asthma

 The American Journal of Respiratory and Critical Care Medicine

Randomized Clinical Trial of the Four Supports Intervention for Surrogate Decision-Makers in Intensive Care Units

 Clinical Journal of American Society of Nephrology

A Pilot Trial of Nicotinamide Riboside and Coenzyme Q10 on Inflammation and Oxidative Stress in CKD

 Kidney International reports

Efficacy and Safety of Rituximab in Antiglomerular Basement Membrane Disease

Obinutuzumab and Ofatumumab are More Effective Than Rituximab in the Treatment of Membranous Nephropathy Patients With Anti-Rituximab Antibodies

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 New England Journal of Medicine

Axillary Surgery in Breast Cancer — Primary Results of the INSEMA Trial

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections

Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage

 Journal of  American Medical Association

Inhaled Sedation in Acute Respiratory Distress SyndromeThe SESAR Randomized Clinical Trial

 Annals of Internal Medicine

Health Expenditures of Patients With Diabetes After Bariatric Surgery: Comparing Gastric Bypass and Sleeve Gastrectomy

  British Medical Journal

Sonolysis during carotid endarterectomy: randomised controlled trial

  Lancet

Direct oral anticoagulants versus no anticoagulation for the prevention of stroke in survivors of intracerebral haemorrhage with atrial fibrillation (PRESTIGE-AF): a multicentre, open-label, randomised, phase 3 trial

  journal of Hepatology

Decreases in cT1 and liver fat content reflect treatment-induced histological improvements in MASH

Exploring algorithms to select candidates for non-selective beta-blockers in cirrhosis: A post hoc analysis of the PREDESCI trial

  Gastroenterology

Creeping Fat–Derived Free Fatty Acids Induce Hyperplasia of Intestinal Muscularis Propria Muscle Cells: A Novel Link Between Fat and Intestinal Stricture Formation in Crohn’s Disease

 Clinical Gastroenterology

 Efficacy and Safety of Gastric Per-Oral Endoscopic Myotomy (G-POEM): A Systematic Review and Meta-Analysis

  Clinical Infectious Diseases

Epidemiology, Risk Factors and Outcome of Neutropenic Enterocolitis in Onco-Hematological Patients according to Chemotherapy Regimen

 Rheumatology 

In‐Depth Analysis of Disease Manifestations in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides Identifies Distinct Clinical Phenotypes

 Journal of Clinical Rheumatology 

Clinical and Imaging Pulmonary Manifestations in IgG4-Related Disease

 Circulation

Stepwise Provisional Versus Systematic Dual-Stent Strategies for Treatment of True Left Main Coronary Bifurcation Lesions

  Journals of the American College of Cardiology

Aortic Valve Replacement vs Clinical Surveillance in Asymptomatic Severe Aortic Stenosis: A Systematic Review and Meta-Analysis

  JAMA Cardiology

Intravascular Sympathetic Stimulation to Facilitate Catheter Ablation of Premature Ventricular Complexes

 Journal of Clinical Endocrinology & Metabolism

Age Difference in the Connection Between Systemic Inflammatory Response and Metabolic Syndrome

 Neurology

Association of Social Determinants of Health With Genetic Test Request and Completion Rates in Children With Neurologic Disorders

 Chest

Isolation of Genetically Distinct Strains Within the Same Species During Treatment of Mycobacterium Avium Complex Pulmonary Disease

  The American Journal of Respiratory and Critical Care Medicine

Timing of Extubation in Adult Patients with Acute Brain Injury

 Clinical Journal of American Society of Nephrology

Biomarker Panels for Predicting Progression of Kidney Disease in Acute Kidney Injury Survivors

  Kidney International reports

GFR is a Key Determinant of Red Blood Cell Survival in Anemia Associated With Progressive CKD

Blood Pressure Goals and Outcomes in Kidney Transplant Recipients in an Analysis of the Collaborative Transplant Study

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New England Journal of Medicine

Axillary Surgery in Breast Cancer — Primary Results of the INSEMA Trial

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections

Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage

 Journal of  American Medical Association

Atezolizumab in High-Risk Locally Advanced Squamous Cell Carcinoma of the Head and Neck

A Randomized Clinical Trial

Adjuvant PD-1 Blockade With Camrelizumab for Nasopharyngeal Carcinoma

The DIPPER Randomized Clinical Trial

 British Medical Journal

Projections for prevalence of Parkinson’s disease and its driving factors in 195 countries and territories to 2050

 Lancet

Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021

  journal of Hepatology

Frailty and risk of metabolic dysfunction-associated steatotic liver disease and other chronic liver diseases

Non-invasive assessment of severe liver fibrosis in patients with Fontan-associated liver disease: The VALDIG-EASL FONLIVER cohort

 Gastroenterology

Creeping Fat–Derived Free Fatty Acids Induce Hyperplasia of Intestinal Muscularis Propria Muscle Cells: A Novel Link Between Fat and Intestinal Stricture Formation in Crohn’s Disease

 Clinical Gastroenterology

Preinjection With Ligation-Assisted Endoscopic Mucosal Resection for Barrett’s Dysplasia and Early Esophageal Adenocarcinoma: Characteristic Histological Features of the Depth of Resection

 Rheumatology 

Changes in Long‐Term Glucocorticoid Use Among Older Adults After New Diagnosis of Late‐Onset Rheumatoid Arthritis

 Journal of Clinical Rheumatology 

Risk of Malignancy Related to Ixekizumab in Patients With Psoriatic Arthritis or Axial Spondyloarthropathy: Systematic Review and Meta-analysis

  Circulation

 Long-Term Efficacy and Safety of Acoramidis in ATTR-CM: Initial Report From the Open-Label Extension of the ATTRibute-CM Trial

 Journals of the American College of Cardiology

Predictors of Outcomes of Reintervention After Transcatheter Aortic Valve Replacement

 Journal of Clinical Endocrinology & Metabolism

Weight-Specific Grip Strength as a Novel Indicator Associated With Cardiometabolic Risk in Children: The EMSNGS Study

 Diabetes care

The Association Between Cost-Related Insulin Rationing and Health Care Utilization in U.S. Adults With Diabetes

 The American Journal of Respiratory and Critical Care Medicine

Impact of Fluid Balance on the Development of Lung Injury

  Clinical Journal of American Society of Nephrology

Perspectives and Experiences of Patients with AKI: A Systematic Review

 Kidney International reports

Randomized Trial of Pegmolesatide for the Treatment of Anemia in Patients With Nondialysis CKD

Influence of Individual- and Area-Level Social Determinants of Health on Likelihood of Living Versus Deceased Donor Kidney Transplantation

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  New England Journal of Medicine

Male-Partner Treatment to Prevent Recurrence of Bacterial Vaginosis

Tirzepatide for Obesity Treatment and Diabetes Prevention

Remibrutinib in Chronic Spontaneous Urticaria

 Journal of  American Medical Association

Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease: A Randomized Clinical Trial

Question  Does the use of coronary artery calcium (CAC) scoring in intermediate-risk patients with a family history of premature coronary artery disease (CAD) lead to less progression of coronary atheroma in follow-up?

Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease

A Randomized Clinical Trial

  Annals of Internal Medicine

Molecular Imaging Versus Adrenal Vein Sampling for the Detection of Surgically Curable Primary Aldosteronism: A Prospective Within-Patient Trial

  British Medical Journal

Projections for prevalence of Parkinson’s disease and its driving factors in 195 countries and  Lancet

A five-drug class model using routinely available clinical features to optimise prescribing in type 2 diabetes: a prediction model development and validation study

 journal of Hepatology

Dysglycemia and liver lipid content determine the relationship of insulin resistance with hepatic OXPHOS capacity in obesity

Hepatocyte aquaporin 8-mediated water transport facilitates bile dilution and prevents gallstone formation in mice

  Gastroenterology

A High-Resolution Microendoscope Improves Esophageal Cancer Screening and Surveillance: Implications for Underserved Global Settings Based on an International Randomized Controlled Trial

 Clinical Gastroenterology

Satisfaction With and Adherence to Off-Label Corticosteroids in Adolescents and Adults With Eosinophilic Esophagitis: Results of a Web-Based Survey in the United States

 Clinical Infectious Diseases

Audit and Feedback Interventions for Antibiotic Prescribing in Primary Care: A Systematic Review and Meta-analysis 

  Rheumatology 

RheuMetric Physician 0 to 10 Estimates of Inflammation, Damage, and Patient Distress at Initial Versus Follow-Up Visits in Contemporary Rheumatology Care

 Journal of Clinical Rheumatology 

Clinical and Imaging Pulmonary Manifestations in IgG4-Related Disease

 Circulation

 Rivaroxaban for 18 Months Versus 6 Months in Patients With Cancer and Acute Low-Risk Pulmonary Embolism: An Open-Label, Multicenter, Randomized Clinical Trial (ONCO PE Trial)

  Journals of the American College of Cardiology

Transcatheter Aortic Valve Replacement in Patients With Systolic Heart Failure and Moderate Aortic Stenosis: TAVR UNLOAD

JAMA Cardiology

Finerenone for Heart Failure and Risk Estimated by the PREDICT-HFpEF ModelA Secondary Analysis of FINEARTS-HF

  Journal of Clinical Endocrinology & Metabolism

Comparison of Cumulative Live Birth Rates Between Progestin and GnRH Analogues in Preimplantation Genetic Testing Cycles

 Diabetes care

Effects of Adopting Preventive Drug Lists on Medication Costs and Disparities by Income Over 2 Years: A Natural Experiment for Translation in Diabetes (NEXT-D) Study

 The American Journal of Respiratory and Critical Care Medicine

Air Hunger Far Exceeds Dyspnea Sense of Effort during Mechanical Ventilation and a Weaning Trial

  Kidney International reports

Pharmacokinetics and Side Effects of Δ9-Tetrahydrocannabinol and Cannabidiol in Patients with Different Stages of CKD

Similar Efficacy in Belatacept-Converted Kidney Transplant Recipients With Steroid-Avoiding Regimen