This Week In Medicine

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Ponsegromab for the Treatment of Cancer Cachexia

Levofloxacin for the Prevention of Multidrug-Resistant Tuberculosis in Vietnam

Ebola Outbreak Response in the DRC with rVSV-ZEBOV-GP Ring Vaccination

Twice-Yearly Depemokimab in Severe Asthma with an Eosinophilic Phenotype

 Journal of  American Medical Association

2024 Update of the RECOVER-Adult Long COVID Research Index

 Annals of Internal Medicine

Risk for Financial Precarity From Hospitalization: Implications for Targeting Financial Assistance in Medicare

 Lancet

Efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn's disease: a phase 3, multicentre, randomised, double-blind, placebo-controlled and active-controlled, treat-through study

 Journal of Clinical Oncology

Omission of Radiotherapy in Primary Mediastinal B-Cell Lymphoma: IELSG37 Trial Results

 Gastroenterology

An Empirical Dietary Pattern Associated With the Gut Microbial Features in Relation to Colorectal Cancer Risk

  Journal of Clinical Rheumatology 

Evaluating Meaningful Changes in Patient‐Reported Outcome Measurement Information System–Fatigue Scores from Three Phase 3 Clinical Trials of Sarilumab for Patients With Rheumatoid Arthritis

 Circulation

NT-proBNP and Cardiac Troponin I, but Not Cardiac Troponin T, Are Associated With 7-Year Changes in Cardiac Structure and Function in Older Adults: The ARIC Study

   Journals of the American College of Cardiology

2-Fold More Cardiovascular Disease Events Decades Before Type 2 Diabetes Diagnosis: A Nationwide Registry Study

 JAMA Cardiology

Amiodarone or Implantable Cardioverter-Defibrillator in Chagas CardiomyopathyThe CHAGASICS Randomized Clinical Trial

Diabetes care

Relationship of Plasma Apolipoprotein C-I Truncation With Risk of Diabetes in the Multi-Ethnic Study of Atherosclerosis and the Actos Now for the Prevention of Diabetes Study

 Chest

Severity of Inhalation Injury and Risk of Nosocomial Pneumonia

Association of RBC Transfusion Thresholds and Outcomes in Medical Patients With Acute Respiratory Failure Supported With Extracorporeal Membrane Oxygenation

  The American Journal of Respiratory and Critical Care Medicine

Association Between Baseline Driving Pressure and Mortality in Very Old Patients with Acute Respiratory Distress Syndrome

  Clinical Journal of American Society of Nephrology

Breast and Prostate Cancer Screening by Life Expectancy in Patients with Kidney Failure on Dialysis

 Kidney International reports

Pilot Trial of Hydroxychloroquine as Add-On Therapy in Patients With Membranous Nephropathy

Urine Protein-to-Creatinine Ratio Remains Informative Despite Nonsteady State Serum Creatinine During Acute Kidney Injury

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 New England Journal of Medicine

PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation

Insulin Efsitora versus Degludec in Type 2 Diabetes without Previous Insulin Treatment

Bedaquiline Monotherapy for Multibacillary Leprosy

Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia

 CRISPR-Cas9 Gene Editing with Nexiguran Ziclumeran for ATTR Cardiomyopathy

Journal of  American Medical Association

Electronic Sepsis Screening Among Patients Admitted to Hospital Wards

Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial

 Annals of Internal Medicine

Development and Evaluation of a Comprehensive Prediction Model for Incident Coronary Heart Disease Using Genetic, Social, and Lifestyle–Psychological Factors: A Prospective Analysis of the UK Biobank

British Medical Journal

Contemporary menopausal hormone therapy and risk of cardiovascular disease: Swedish nationwide register based emulated target trial

Lancet

National-level and state-level prevalence of overweight and obesity among children, adolescents, and adults in the USA, 1990–2021, and forecasts up to 2050

Journal of Clinical Oncology

Clinical Outcomes and Histologic Findings of Patients With Hepatocellular Carcinoma With Durable Partial Response or Durable Stable Disease After Receiving Atezolizumab Plus Bevacizumab

Hepatology

Low-to-moderate alcohol consumption is associated with increased fibrosis in individuals with metabolic dysfunction-associated steatotic liver disease

 Gastroenterology

 Exon-Skipping–Based Subtyping of Colorectal Cancers

Rheumatology 

Revisiting the Link Between HLA-DRB1 Alleles and Autoantibodies in Rheumatoid Arthritis: Association of non-Shared Epitope Alleles *09 and *15 With High Levels of Anti–Citrullinated Peptide/Protein Antibodies

 Journal of Clinical Rheumatology 

Periprosthetic Joint Infection in Patients With Inflammatory Arthritis: Optimal Tests to Differentiate From Flares

 Circulation

Randomized Invitation to Systematic NT-proBNP and ECG Screening in 75-Year-Olds to Detect Atrial Fibrillation: STROKESTOP II

  Journals of the American College of Cardiology

Hospitalization of Symptomatic Patients With Heart Failure and Moderate to Severe Functional Mitral Regurgitation Treated With MitraClip: Insights From RESHAPE-HF2

Endocrinology

 Diabetes care

Initiation of Intermittently Scanned Continuous Glucose Monitoring Is Associated With Reduced Hospitalization for Acute Diabetes Events and Cardiovascular Complications in Adults With Type 1 Diabetes

Chest

Impact of Dyspnea on Adults With Respiratory Symptoms Without a Defined Diagnosis

Comparison of Early and Late Norepinephrine Administration in Patients With Septic Shock

The American Journal of Respiratory and Critical Care Medicine

Application of the European Respiratory Society/American Thoracic Society Spirometry Standards and Race-Neutral Equations in the COPDGene Study

Next we will be discussing articles In the field of Nephrology

Clinical Journal of American Society of Nephrology

Bioimpedance-Guided Fluid Removal in Continuous KRT: The VENUS Randomized Clinical Trial

Kidney International reports

Anti Phospholipase A2 Receptor 1 Antibodies and Membranous Nephropathy Recurrence After Kidney Transplantation

Combination Therapy With Rituximab and Low-Dose Cyclophosphamide and Prednisone in Membranous Nephropathy

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  New England Journal of Medicine

Edoxaban Antithrombotic Therapy for Atrial Fibrillation and Stable Coronary Artery Disease

Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women

Xalnesiran with or without an Immunomodulator in Chronic Hepatitis B

Trastuzumab Deruxtecan after Endocrine Therapy in Metastatic Breast Cancer

Prenatal cfDNA Sequencing and Incidental Detection of Maternal Cancer

  Journal of  American Medical Association

HepB-CpG vs HepB-Alum Vaccine in People With HIV and Prior Vaccine NonresponseQuestion  Does vaccination with a hepatitis B vaccine with a cytosine phosphoguanine adjuvant (HepB-CpG vaccine) improve hepatitis B virus (HBV) seroprotection in people with HIV and nonresponse to prior hepatitis B vaccine?

Message Reminders to Improve Adherence to Chronic Cardiovascular Medications

 Annals of Internal Medicine

A Framework for Considering the Value of Race and Ethnicity in Estimating Disease Risk

  British Medical Journal

Chocolate intake and risk of type 2 diabetes: prospective cohort studies

 Lancet

Balloon guide catheters for endovascular thrombectomy in patients with acute ischaemic stroke due to large-vessel occlusion in China (PROTECT-MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial

 Journal of Clinical Oncology

Phase III KEYNOTE-789 Study of Pemetrexed and Platinum With or Without Pembrolizumab for Tyrosine Kinase Inhibitor‒Resistant, EGFR–Mutant, Metastatic Nonsquamous Non–Small Cell Lung Cancer

  journal of Hepatology

Differing genetic variants associated with liver fat and their contrasting relationships with cardiovascular diseases and cancer

  Gastroenterology

Atlas of Metastatic Gastric Cancer Links Ferroptosis to Disease Progression and Immunotherapy Response

 Rheumatology 

 Axial Spondyloarthritis in Black Americans: An Observational Study From Five Centers in Shelby County, Tennessee

 Journal of Clinical Rheumatology 

Anticoagulant Treatment May Decrease the Relapse Rate of Pulmonary Arterial Involvement in Behçet’s Disease

  Circulation

 Restrictive Versus Liberal Transfusion in Patients With Type 1 or Type 2 Myocardial Infarction: A Prespecified Analysis of the MINT Trial

 Journals of the American College of Cardiology

Major Bleeding and Mortality After Revascularization of Left Main Disease

Diabetes care

Clinical Prediction Models Combining Routine Clinical Measures Have High Accuracy in Identifying Youth-Onset Type 2 Diabetes Defined by Maintained Endogenous Insulin Secretion: The SEARCH for Diabetes in Youth Study

 American Journal of Respiratory and Critical Care Medicine

Severity of Airflow Obstruction Based on FEV1/FVC Versus FEV1 Percent 

Kidney International reports

Prognosis for Type 1 Diabetes with Diabetic Nephropathy between 2000 and 2020 - Changes in Kidney Function Decline Over Time and Development of Cardiovascular Disease, Kidney Failure, and Mortality

Evaluation of Race-Neutral Glomerular Filtration Rate Estimating Equations in an Indian Population

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 New England Journal of Medicine

Overall Survival with Pembrolizumab in Early-Stage Triple-Negative Breast Cancer

Fractional Doses of Pneumococcal Conjugate Vaccine — A Noninferiority Trial

Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer

 Journal of  American Medical Association

Association of Severe Maternal Morbidity With Subsequent Birth

Intravenous Lidocaine for Gut Function Recovery in Colonic Surgery

Transcatheter Edge-to-Edge Repair for Severe Isolated Tricuspid Regurgitation

The Tri.Fr Randomized Clinical Trial

  Annals of Internal Medicine

Association of Work Control With Burnout and Career Intentions Among U.S. Physicians: A Multi-Institution Stud

  British Medical Journal

Contemporary menopausal hormone therapy and risk of cardiovascular disease

 Lancet

Balloon guide catheters for endovascular thrombectomy in patients with acute ischaemic stroke due to large-vessel occlusion in China (PROTECT-MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial

 Cancer Journal for Clinicians

A phase 2 study of a brachyury-targeting vaccine in combination with radiation therapy for the treatment of advanced chordoma

 Journal of Clinical Oncology

Prospective Study of Supplemental Screening With Contrast-Enhanced Mammography in Women With Elevated Risk of Breast Cancer: Results of the Prevalence Round

 journal of Hepatology

Efficacy, tolerability and pharmacokinetics of survodutide, a glucagon/glucagon-like peptide-1 receptor dual agonist, in cirrhosis

Glutaryl-CoA dehydrogenase suppresses tumor progression and shapes an anti-tumor microenvironment in hepatocellular carcinoma

 Gastroenterology

Gut Pathobiont–Derived Outer Membrane Vesicles Drive Liver Inflammation and Fibrosis in Primary Sclerosing Cholangitis–Associated Inflammatory Bowel Disease

 Clinical Gastroenterology

 Updated Reference Intervals for Alanine Aminotransferase in a Metabolically and Histologically Normal Population

   Clinical Infectious Diseases

The Use of Long-term Antibiotics for Suppression of Bacterial Infections 

 Rheumatology 

Implementing Patient Health Questionnaire Depression Screening in Inflammatory Arthritis Clinic

   Journal of Clinical Rheumatology 

 Circulation

ErbB3 Governs Endothelial Dysfunction in Hypoxia-Induced Pulmonary Hypertension

  Journals of the American College of Cardiology

Recaticimab Monotherapy for Nonfamilial Hypercholesterolemia and Mixed Hyperlipemia: The Phase 3 REMAIN-1 Randomized Trial

  JAMA Cardiology

Routine Protamine Administration for Bleeding in Transcatheter Aortic Valve ImplantationThe ACE-PROTAVI Randomized Clinical Trial

 Journal of Clinical Endocrinology & Metabolism

Obesity, Inflammation, and Clinical Outcomes in COVID-19: A Multicenter Prospective Cohort Study 

 Diabetes care

Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study

   Neurology

SGLT2 Inhibitor Use and Risk of Dementia and Parkinson Disease Among Patients With Type 2 Diabetes

 Chest

Rethinking Blood Eosinophils for Assessing Inhaled Corticosteroids Response in COPD

  The American Journal of Respiratory and Critical Care Medicine

Preacinar Arterial Dilation Mediates Outcomes of Quantitative Interstitial Abnormalities in the COPDGene Study

 Clinical Journal of American Society of Nephrology

Acute Myocardial Infarction and Chronic Kidney Disease: A Nationwide Cohort Study on Management and Outcomes from 2010 to 2022

 Kidney International reports

Randomized Trial of Patiromer on Efficacy to Reduce Episodic Hyperkalemia in Patients with ESKD Treated With Hemodialysis

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 in New England Journal of Medicine

Nationwide, Couple-Based Genetic Carrier Screening

Adjunctive Middle Meningeal Artery Embolization for Subdural Hematoma

Safety and Efficacy of Immunization with a Late-Liver-Stage Attenuated Malaria Parasite

  Journal of  American Medical Association

Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores

Zerlasiran—A Small-Interfering RNA Targeting Lipoprotein(a): A Phase 2 Randomized Clinical Trial

 Annals of Internal Medicine

The Effect of Denosumab on Risk for Emergently Treated Hypocalcemia by Stage of Chronic Kidney Disease

  British Medical Journal

Nurse and doctor turnover and patient outcomes in NHS acute trusts in England

 Lancet

Induced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan

  Cancer Journal for Clinicians

Efficacy and safety of nivolumab monotherapy in patients with unresectable clear cell sarcoma and alveolar soft part sarcoma 

 Journal of Clinical Oncology

Trastuzumab Deruxtecan in Advanced Solid Tumors With Human Epidermal Growth Factor Receptor 2 Amplification Identified by Plasma Cell-Free DNA Testing: A Multicenter, Single-Arm, Phase II Basket Trial

  Hepatology

Sodium taurocholate cotransporting polypeptide (NTCP) polymorphisms may influence HDV RNA load and early response to bulevirtide

Hepatic venous pressure gradient predicts risk of hepatic decompensation and liver-related mortality in patients with MASLD

 Gastroenterology

 Molecular Mechanisms Underlying Loss of Vascular and Epithelial Integrity in Irritable Bowel Syndrome

 Clinical Gastroenterology

 Prevalence and Determinants of Liver Disease in Relatives of Italian Patients With Advanced MASLD

  Clinical Infectious Diseases

Prevalence, Clinical Severity, and Serotype Distribution of Pneumococcal Pneumonia Among Adults Hospitalized With Community-Acquired Pneumonia in Tennessee and Georgia, 2018–2022

 Rheumatology 

Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis

  Journal of Clinical Rheumatology 

Prevalence and Clinical Implications of Autoantibodies in Juvenile Dermatomyositis: A Single-Center Experience From India

   Circulation

Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction

 Journals of the American College of Cardiology

Complete vs Culprit-Only Revascularization in Older Patients With Myocardial Infarction With or Without ST-Segment Elevation

  JAMA Cardiology

Verinurad Plus Allopurinol for Heart Failure With Preserved Ejection FractionThe AMETHYST Randomized Clinical Trial

 Journal of Clinical Endocrinology & Metabolism

Hemostatic Effects of Exercise-related Hypoglycemia in Male Persons With Type 1 Diabetes

 Diabetes care

Trends in Racial and Ethnic Disparities in Early Glycemic Control Among Veterans Receiving Care in the Veterans Health Administration, 2008–2019 

  Neurology

Quantitative MRI Measures and Cognitive Function in People With Drug-Resistant Juvenile Myoclonic Epilepsy

 Chest

Air Pollution Metabolomic Signatures and Chronic Respiratory Diseases Risk

A Longitudinal Study

  The American Journal of Respiratory and Critical Care Medicine

Lung-Protective Mechanical Ventilation in Patients with Severe Acute Brain Injury: A Multicenter Randomized Clinical Trial (PROLABI)

  Clinical Journal of American Society of Nephrology

Physical Function and Mortality in Older Adults with Chronic Kidney Disease

 Kidney International reports

Associations of Urine Epidermal Growth Factor With Kidney and Cardiovascular Outcomes in Individuals With CKD in SPRINT

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 New England Journal of Medicine

Perioperative Durvalumab with Neoadjuvant Chemotherapy in Operable Bladder Cancer

Transcatheter Repair versus Mitral-Valve Surgery for Secondary Mitral Regurgitation

Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation

Preoperative Chemoradiotherapy for Resectable Gastric Cancer

  Journal of  American Medical Association

Symptom Screening Linked to Care Pathways for Pediatric Patients With Cancer: A Randomized Clinical Trial

Tenofovir and Hepatitis B Virus Transmission During Pregnancy

Symptom Screening Linked to Care Pathways for Pediatric Patients With Cancer

 Annals of Internal Medicine

Association Between False-Positive Results and Return to Screening Mammography in the Breast Cancer Surveillance Consortium Cohort

 British Medical Journal

SGLT-2 inhibitors and mortality among patients with heart failure with reduced ejection fraction

Malnutrition in infants aged 6-23 months in China’s poorest rural counties from 2016 to 2021

 Lancet

Genetic sequencing analysis of monkeypox virus clade I in Republic of the Congo: a cross-sectional, descriptive study

  Cancer Journal for Clinicians

Comparison of infection risk between enzalutamide and abiraterone in patients with prostate cancer

 Journal of Clinical Oncology

Stockholm3 in a Multiethnic Cohort for Prostate Cancer Detection (SEPTA): A Prospective Multicentered Trial

 Hepatology

CRISPR-Cas13b-mediated suppression of HBV replication and protein expression

Epigenetic scars in regulatory T cells are retained after successful treatment of chronic hepatitis C with direct-acting antivirals

  Gastroenterology

The Global Incident Gastrointestinal Cancers Attributable to Suboptimal Diets From 1990 to 2018

 Clinical Gastroenterology

 The Efficacy of Real-time Computer-aided Detection of Colonic Neoplasia in Community Practice: A Pragmatic Randomized Controlled Trial

 Clinical Infectious Diseases

Preventing New Gram-negative Resistance Through Beta-lactam De-escalation in Hospitalized Patients With Sepsis: A Retrospective Cohort Study 

  Rheumatology 

Gout Flare Burden in the United States: A Multiyear Cross‐Sectional Survey Study

 Journal of Clinical Rheumatology 

Development and Validation of Nosocomial Bacterial Infection Prediction Models for Patients With Systemic Lupus Erythematosus

  Circulation

 Complete Versus Culprit-Only Revascularization in Older Patients With ST-Segment–Elevation Myocardial Infarction: An Individual Patient Meta-Analysis

   Journals of the American College of Cardiology

Comprehensive Proteomic Profiling of Human Myocardium Reveals Signaling Pathways Dysregulated in Hypertrophic Cardiomyopathy

  JAMA Cardiology

Prehospital Pulse-Dose Glucocorticoid in ST-Segment Elevation Myocardial InfarctionThe PULSE-MI Randomized Clinical Trial

 Journal of Clinical Endocrinology & Metabolism

Medullary Thyroid Cancer: Single Institute Experience Over 3 Decades and Risk Factors for Recurrence

 Diabetes care

Development of a Core Outcome Set for Studies Assessing Interventions for Diabetes-Related Foot Ulceration

  Neurology

Identification of Genetic Loci Associated With Intracerebral Hemorrhage Using a Multitrait Analysis Approach

  Chest

Sex Differences After Treatment With Ivacaftor in People With Cystic Fibrosis

 The American Journal of Respiratory and Critical Care Medicine

Low-Dose Morphine Does Not Cause Sleepiness in Chronic Obstructive Pulmonary Disease: A Secondary Analysis of a Randomized Clinical Trial

  Clinical Journal of American Society of Nephrology

Association between Chronic Kidney Disease-Mineral and Bone Disorder Biomarkers and Symptom Burden in Older Patients with Advanced Chronic Kidney Disease: Results from the EQUAL Study

  Kidney International reports

IMPACT CKD: Holistic Disease Model Projecting 10-Year Population Burdens

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 New England Journal of Medicine

Invasive Treatment Strategy for Older Patients with Myocardial Infarction

Randomized Trial of Very Early Medication Abortion

Neoadjuvant Nivolumab and Ipilimumab in Resectable Stage III Melanoma

Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma

  Journal of  American Medical Association

Postmarketing Surveillance of Inferior Vena Cava Filters Among US Medicare Beneficiaries

The SAFE-IVC Study

A Digital Health Behavior Intervention to Prevent Childhood Obesity

The Greenlight Plus Randomized Clinical Trial

  Annals of Internal Medicine

Ensuring Safe Practice by Late Career Physicians: Institutional Policies and Implementation Experiences

 British Medical Journal

SGLT-2 inhibitors and mortality among patients with heart failure with reduced ejection fraction

  Lancet

Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial

  Cancer Journal for Clinicians

Epidemiology, treatment patterns, and clinical outcomes in de novo oligometastatic hormone-sensitive prostate cancer

 Journal of Clinical Oncology

Addition of Metastasis-Directed Therapy to Systemic Therapy for Oligometastatic Pancreatic Ductal Adenocarcinoma (EXTEND): A Multicenter, Randomized Phase II Trial

  journal of Hepatology

Diagnostic performance of non-invasive tests in patients with MetALD in a health check-up cohort

Histological improvements following energy restriction and exercise: The role of insulin resistance in resolution of MASH

 Gastroenterology

Gluten-Dependent Activation of CD4+ T Cells by MHC Class II–Expressing Epithelium

 Clinical Gastroenterology

 Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial

 Clinical Infectious Diseases

Successful Treatment of Carbapenem-Resistant Acinetobacter baumannii Meningitis With Sulbactam-Durlobactam

 Rheumatology 

Comprehensive Enteroviral Serology Links Infection and Anti‐Melanoma Differentiation‐Associated Protein 5 Dermatomyositis

 Journal of Clinical Rheumatology 

 Factors Associated With Successful Withdrawal of Biologic Agents in Children With Colchicine-Resistant Familial Mediterranean Fever

   Circulation

Contemporary Outcomes and Trends for the Transseptal Mitral Valve-in-Valve Procedure Using Balloon Expandable Transcatheter Valves in the United States

  Journals of the American College of Cardiology

Reaffirmation of Mechanistic Proteomic Signatures Accompanying SGLT2 Inhibition in Patients With Heart Failure: A Validation Cohort of the EMPEROR Program

Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

  Journal of Clinical Endocrinology & Metabolism

Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas 

 Diabetes care

Health Care Utilization and Costs Associated With Empagliflozin in Older Adults With Type 2 Diabetes

 Neurology

Frequency and Longitudinal Course of Behavioral and Neuropsychiatric Symptoms in Participants With Genetic Frontotemporal Dementia

  Chest

Primary Ciliary Dyskinesia in Adult Bronchiectasis

  American Journal of Respiratory and Critical Care Medicine

Discovery and Validation of a Volatile Signature of Eosinophilic Airway Inflammation in Asthma

 Clinical Journal of American Society of Nephrology

Urine Output and Acute Kidney Injury in Neonates/Younger Children: A Prospective Study of Cardiac Surgery Patients with Indwelling Urinary Catheters

Large Discordance between Creatinine-Based and Cystatin C–Based eGFRs is Associated with Falls, Hospitalizations, and Death in Older Adults

  Kidney International reports

Systematic Review of Individual Patient Data COVID-19 Infection and Vaccination–Associated Thrombotic Microangiopathy

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 New England Journal of Medicine

Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis

Inavolisib-Based Therapy in PIK3CA-Mutated Advanced Breast Cancer

Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma

Total Hip Replacement or Resistance Training for Severe Hip Osteoarthritis

  from Journal of  American Medical Association

Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis

The EVOLVED Randomized Clinical Trial

 Annals of Internal Medicine

Projected Impact and Cost-Effectiveness of Novel Molecular Blood-Based or Stool-Based Screening Tests for Colorectal Cancer

Comparative Effectiveness and Safety of Atorvastatin Versus Rosuvastatin: A Multi-database Cohort Study

  British Medical Journal

Comparative effectiveness of sodium-glucose cotransporter-2 inhibitors for recurrent nephrolithiasis among patients with pre-existing nephrolithiasis or gout: target trial emulation studies

 Lancet

The effect of tranexamic acid on postpartum bleeding in women with moderate and severe anaemia (WOMAN-2): an international, randomised, double-blind, placebo-controlled trial

 Journal of Clinical Oncology

Randomized Phase II Trial of Immunotherapy-Based Total Neoadjuvant Therapy for Proficient Mismatch Repair or Microsatellite Stable Locally Advanced Rectal Cancer (TORCH)

 journal of Hepatology

Histological improvements following energy restriction and exercise: The role of insulin resistance in resolution of MASH

 Gastroenterology

A Single-Cell Atlas of the Murine Pancreatic Ductal Tree Identifies Novel Cell Populations With Potential Implications in Pancreas Regeneration and Exocrine Pathogenesis

Fazirsiran for Adults With Alpha-1 Antitrypsin Deficiency Liver Disease: A Phase 2 Placebo Controlled Trial (SEQUOIA)

  Clinical Infectious Diseases

Evidence-Informed Provision of Doxycycline Post-Exposure Prophylaxis for Prevention of Bacterial Sexually Transmitted Infections

Abstract

  Rheumatology 

Implementing Patient Health Questionnaire Depression Screening in Inflammatory Arthritis Clinic: Insights From a Quality Improvement Project at a Tertiary Rheumatology Center

  Circulation

RNA Helicase DDX5 Maintains Cardiac Function by Regulating CamkIIδ Alternative Splicing

 Journals of the American College of Cardiology

Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis

 JAMA Cardiology

Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

 Journal of Clinical Endocrinology & Metabolism

Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas 

 Diabetes care

Sitting Time and Its Interaction With Physical Activity in Relation to All-Cause and Heart Disease Mortality in U.S. Adults With Diabetes

The American Journal of Respiratory and Critical Care Medicine

The Effect of Positive End-Expiratory Pressure on Pulmonary Vascular Resistance Depends on Lung Recruitability in Patients with Acute Respiratory Distress Syndrome

Rationale: A U-shaped relationship should exist between lung volume and  Kidney International reports

Prospective Trial on the Pharmacokinetics of Clopidogrel in Hemodialysis Patients

A Survey on End-of-Life Contemplation Among Patients on Dialysis

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New England Journal of Medicine

Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction

Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC

 Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture

 Journal of  American Medical Association

Dialysis Facility Staffing Ratios and Kidney Transplant Access Among Adolescents and Young Adults

Expanded Newborn Screening Using Genome Sequencing for Early Actionable Conditions

  Annals of Internal Medicine

Colorectal Cancer Screening Completion and Yield in Patients Aged 45 to 50 Years: An Observational Study

 British Medical Journal

Association of holidays and the day of the week with suicide risk: multicounty, two stage, time series study

  Lancet

Induction chemotherapy followed by standard chemoradiotherapy versus standard chemoradiotherapy alone in patients with locally advanced cervical cancer (GCIG INTERLACE): an international, multicentre, randomised phase 3 trial

  Journal of Clinical Oncology

Social Characteristics and Adherence to Adjuvant Endocrine Therapy in Premenopausal Women With Breast Cancer

 journal of Hepatology

Diagnostic performance of non-invasive tests in patients with MetALD in a health check-up cohort

 Gastroenterology

Effect of Brain-Gut Behavioral Treatments on Abdominal Pain in Irritable Bowel Syndrome: Systematic Review and Network Meta-Analysis

Targeting 5-Hydroxytryptamine Receptor 1A in the Portal Vein to Decrease Portal Hypertension

 Clinical Gastroenterology

Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial

 Clinical Infectious Diseases

Comparative safety of different antibiotic regimens for the treatment of outpatient community-acquired pneumonia among otherwise healthy adults

 Journal of Clinical Rheumatology 

Factors Associated With Successful Withdrawal of Biologic Agents in Children With Colchicine-Resistant Familial Mediterranean Fever

 Circulation

Novel Long Noncoding RNA HEAT4 Affects Monocyte Subtypes, Reducing Inflammation and Promoting Vascular Healing

 Journals of the American College of Cardiology

Heart Failure Risk Assessment Using Biomarkers in Patients With Atrial Fibrillation: Analysis From COMBINE-AF

Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

 Journal of Clinical Endocrinology & Metabolism

Obesity, Inflammation, and Clinical Outcomes in COVID-19: A Multicenter Prospective Cohort Study

  Diabetes care

Empowering Hospitalized Patients With Diabetes: Implementation of a Hospital-wide CGM Policy With EHR-Integrated Validation for Dosing Insulin 

Use of Financial Incentives to Promote Adolescent Type 1 Diabetes Self-management: A Pilot Randomized Controlled Trial

 Neurology

Frequency and Longitudinal Course of Behavioral and Neuropsychiatric Symptoms in Participants With Genetic Frontotemporal Dementia

Chest

Characteristics of Adults With Severe Asthma in Childhood

A 60-Year Follow-Up Study

 The American Journal of Respiratory and Critical Care Medicine

Genetically Predicted Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease

 Clinical Journal of American Society of Nephrology

Urine Output and Acute Kidney Injury in Neonates/Younger Children: A Prospective Study of Cardiac Surgery Patients with Indwelling Urinary Catheters

 Kidney International reports

Elevated Ambient Temperature Associated With Increased Cardiovascular Disease–Risk Among Patients on Hemodialysis

Lower Parathyroid Hormone Levels are Associated With Reduced Fracture Risk in Japanese Patients on Hemodialysis

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 New England Journal of Medicine

Nivolumab+AVD in Advanced-Stage Classic Hodgkin’s Lymphoma

Safety of Kidney Transplantation from Donors with HIV

A Modular Communicative Leadless Pacing–Defibrillator System

Phase 3 Trial of Stereotactic Body Radiotherapy in Localized Prostate Cancer

 Journal of  American Medical Association

Testing and Evaluation of Health Care Applications of Large Language Models

A Systematic Review

  Annals of Internal Medicine

School Mask Mandates and COVID-19: The Challenge of Using Difference-in-Differences Analysis of Observational Data to Estimate the Effectiveness of a Public Health Intervention

 British Medical Journal

Paternal metformin use and risk of congenital malformations in offspring in Norway and Taiwan: population based, cross national cohort study

Progress of nations in the organisation of, and structures for, kidney care delivery between 2019 and 2023: cross sectional survey in 148 countries

  Lancet

Reductions in recurrence in women with early breast cancer entering clinical trials between 1990 and 2009: a pooled analysis of 155 746 women in 151 trials

 Journal of Clinical Oncology

Human Leukocyte Antigen Mismatching and Survival in Contemporary Hematopoietic Cell Transplantation for Hematologic Malignancies

 journal of Hepatology

Diagnostic performance of non-invasive tests in patients with MetALD in a health check-up cohort

  Gastroenterology

Subcutaneous Infliximab (CT-P13 SC) as Maintenance Therapy for Inflammatory Bowel Disease: Two Randomized Phase 3 Trials (LIBERTY)

Prognostic Factors for Early Recurrence After Resection of Pancreatic Cancer: A Systematic Review and Meta-Analysis

  Clinical Infectious Diseases

Successful Treatment of Carbapenem-Resistant Acinetobacter baumannii Meningitis With Sulbactam-Durlobactam

  Rheumatology 

Leveraging Habits to Improve Adherence to Gout Medications: A Qualitative Study

  Journal of Clinical Rheumatology 

Development and Validation of Nosocomial Bacterial Infection Prediction Models for Patients With Systemic Lupus Erythematosus

  Circulation

Neurofilament Light Chain and Risk of Stroke in Patients With Atrial Fibrillation

  Journals of the American College of Cardiology

Bivalirudin vs Heparin Anticoagulation in STEMI: Confirmation of the BRIGHT-4 Results

 JAMA Cardiology

Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

 Journal of Clinical Endocrinology & Metabolism

Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas

  Diabetes care

Discrepancy Between Genetically Predicted and Observed BMI Predicts Incident Type 2 Diabetes

Associations of High BMI and Excessive Gestational Weight Gain With Pregnancy Outcomes in Women With Type 1 Diabetes

  Neurology

Association of Polygenic Risk Score With Lifetime Risk of Developing Multiple Sclerosis in a Population-Based Birth-Year Cohort

  Chest

Characteristics of Adults With Severe Asthma in Childhood

  The American Journal of Respiratory and Critical Care Medicine

Impact of Using Pre- and Postbronchodilator Spirometry Reference Values in a Chinese Population

 Clinical Journal of American Society of Nephrology

Urine Output and Acute Kidney Injury in Neonates/Younger Children: A Prospective Study of Cardiac Surgery Patients with Indwelling Urinary Catheters

 Kidney International reports

Imlifidase in Highly Sensitized Kidney Transplant Recipients With a Positive Crossmatch Against a Deceased Donor

Losing Much More Than a Transplant: A Qualitative Study of Kidney Transplant Recipients’ Experiences of Graft Failure