This Week In Medicine

Hi, This Week in Medicine, we will be discussing

 New England Journal of Medicine

Belantamab Mafodotin, Bortezomib, and Dexamethasone for Multiple Myeloma

 Belantamab Mafodotin, Pomalidomide, and Dexamethasone in Multiple Myeloma

Autoantibodies Targeting Nephrin in Podocytopathies

  Journal of  American Medical Association

Projected Changes in Statin and Antihypertensive Therapy Eligibility With the AHA PREVENT Cardiovascular Risk Equations

Addiction Consultation Services for Opioid Use Disorder Treatment Initiation and EngagementA Randomized Clinical Trial

 Annals of Internal Medicine

Fatal and Nonfatal Firearm Injury Rates by Race and Ethnicity in the United States, 2019 to 2020

  British Medical Journal

Intraosseous versus intravenous vascular access in upper extremity among adults with out-of-hospital cardiac arrest: cluster randomised clinical trial (VICTOR trial)

  Lancet

Safety and efficacy of subcutaneous iscalimab (CFZ533) in two distinct populations of patients with Sjögren's disease (TWINSS): week 24 results of a randomised, double-blind, placebo-controlled, phase 2b dose-ranging study

  Hepatology

Post-treatment LSM rather than change during treatment predicts decompensation in patients with cACLD after HCV cure

 Clinical Gastroenterology

Effects of Food Insecurity on Hepatic Steatosis and Fibrosis in People With HIV

Vedolizumab, Adalimumab, and Methotrexate Combination Therapy in Crohn’s Disease (EXPLORER)

 Clinical Infectious Diseases

Community-Acquired Staphylococcus aureus Bacteremia Among People Who Inject Drugs: A National Cohort Study in England, 2017–2020 

A Randomized, Double-Blind, Phase 3 Safety and Efficacy Study of Ridinilazole Versus Vancomycin for Treatment of Clostridioides difficile Infection: Clinical Outcomes With Microbiome and Metabolome Correlates of Response 

 Arthritis and Rheumatology

Intra-Articular Mineralization on Computerized Tomography of the Knee and Risk of Cartilage Damage: The Multicenter Osteoarthritis Study

  Journals of the American College of Cardiology

Apixaban vs Aspirin According to CHA2DS2-VASc Score in Subclinical Atrial Fibrillation: Insights From ARTESiA

Semaglutide and NYHA Functional Class in Obesity-Related Heart Failure With Preserved Ejection Fraction: The STEP-HFpEF Program

 Journal of Clinical Endocrinology & Metabolism

Comparison of the Efficacy of Ezetimibe Combination Therapy and High-Intensity Statin Monotherapy in Type 2 Diabetes

   Neurology

Mechanisms of Hypercoagulability Driving Stroke Risk in Obesity: A Mendelian Randomization Study

  Chest

The Efficacy and Safety of Inhaled Antibiotics for the Treatment of Bronchiectasis in Adults

Early Deep Sedation Practices Worsened During the Pandemic Among Adult Patients Without COVID-19

  The American Journal of Respiratory and Critical Care Medicine

High Airway Occlusion Pressure Is Associated with Dyspnea and Increased Mortality in Critically Ill Mechanically Ventilated Patients

Clinical Journal of American Society of Nephrology

Genomic Testing in Patients with Kidney Failure of an Unknown Cause: A National Australian Study

  Kidney International reports

Randomized Controlled Trial of Intradialytic Cognitive and Physical Training to Enhance Functional Capacity

Outcomes of Early Versus Delayed Anemia Treatment in Nondialysis-Dependent CKD

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P2Y12 Inhibitors Refill Gap Predicts Death in Medicare Beneficiaries on Chronic Dialysis

Spectrum of Kidney Biopsy Findings Associated With Methamphetamine Use

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Tirzepatide for Metabolic Dysfunction–Associated Steatohepatitis with Liver Fibrosis

Blinatumomab for MRD-Negative Acute Lymphoblastic Leukemia in Adults

Journal of  American Medical Association

Association Between Cost Sharing and Naloxone Prescription Dispensing

Next we will be discussing articles  from Annals of Internal Medicine

Effect of Acupuncture for Methadone Reduction: A Randomized Clinical Trial

Next we will be discussing articles  from British Medical Journal

Effectiveness of behavioural interventions with motivational interviewing on physical activity outcomes

Next we will be discussing articles  from Lancet

Effectiveness and cost-effectiveness of an individualised, progressive walking and education intervention for the prevention of low back pain recurrence in Australia (WalkBack): a randomised controlled trial

Next we will be discussing articles In the field of Hemato Oncology.

Here are the  articles  from Journal of Clinical Oncology

CONTACT-01: A Randomized Phase III Trial of Atezolizumab + Cabozantinib Versus Docetaxel for Metastatic Non–Small Cell Lung Cancer After a Checkpoint Inhibitor and Chemotherapy

Clonal Hematopoiesis and Therapy-Related Myeloid Neoplasms After Autologous Transplant for Hodgkin Lymphoma

Here are the articles    from journal of Hepatology

Sex and ethnic disparities in hepatitis B evaluation and treatment across the world

Next we will be discussing articles In the field of Gastroenterology

Here are the  articles   from Clinical Gastroenterology

 Association Between Celiac Disease and Irritable Bowel Syndrome: A Nationwide Cohort Study

Long-Term Effectiveness and Durability of COVID-19 Vaccination Among Patients With Inflammatory Bowel Disease

Low Colorectal Cancer Risk After Resection of High-Risk Pedunculated Polyps

Next we will be discussing articles In the field of Infectious Diseases

Here are the  articles   from  Clinical Infectious Diseases

Excellence in Antibiotic Stewardship: A Mixed-Methods Study Comparing High-, Medium-, and Low-Performing Hospitals

Next we will be discussing articles In the field of Rheumatology 

Here are the  articles   from  Journal of Clinical Rheumatology 

Causality Assessment Between Idiopathic Inflammatory Myopathies and Lung Cancer: A Bidirectional 2-Sample Mendelian Randomization

Here are the  articles   from   Arthritis and Rheumatology

Effect of Intravenous Zoledronic Acid on Total Knee Replacement in Patients With Symptomatic Knee Osteoarthritis and Without Severe Joint Space Narrowing

Next we will be discussing articles In the field of Cardiology

Here are the  articles   from   Journals of the American College of Cardiology

Impact of Anatomical and Viability-Guided Completeness of Revascularization on Clinical Outcomes in Ischemic Cardiomyopathy

Racial Differences in Diabetic Cardiomyopathy: The ARISE-HF Trial

Next we will be discussing articles In the field of Endocrinology

Here are the  articles   from Journal of Clinical Endocrinology & Metabolism

Depressive Syndromes in Men With Hypogonadism in the TRAVERSE Trial: Response to Testosterone-Replacement Therapy

Next we will be discussing articles In the field of  Neurology

Here are the  articles   from  Neurology

Functional Outcome and Hemorrhage Rates After Bridging Therapy With Tenecteplase or Alteplase in Patients With Large Ischemic Core

Next we will be discussing articles In the field of Pulmonary and Critical care

Here are the  articles   from  Chest

Anaerobic Antibiotic Coverage in Aspiration Pneumonia and the Associated Benefits and Harms

A RETROSPECTIVE COHORT STUDY

Achieving Goals of Care Decisions in Chronic Critical Illness

A MULTI-INSTITUTIONAL QUALITATIVE STUDY

Here are the  articles   from The American Journal of Respiratory and Critical Care Medicine

Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in Chronic Obstructive Pulmonary Disease

Next we will be discussing articles In the field of Nephrology

Clinical Journal of American Society of Nephrology

Kinetics of β-2-Microglobulin with Hemodiafiltration and High-Flux Hemodialysis

Kidney International reports

Endothelial Dysfunction Biomarkers and CKD Incidence in the REGARDS Cohort

Global Validation of a Model to Predict Reduced Estimated GFR in People With Type 2 Diabetes Without Diagnosis of CKD

Prognostication After Dialysis Withdrawal

The Efficacy and Safety of Reduced-Dose Oral Methylprednisolone in High-Risk Immunoglobulin A Nephropathy

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Tenecteplase for Ischemic Stroke at 4.5 to 24 Hours without Thrombectomy

Risankizumab versus Ustekinumab for Moderate-to-Severe Crohn’s Disease

Oral Nirmatrelvir–Ritonavir as Postexposure Prophylaxis for Covid-19

Journal of  American Medical Association

Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac SurgeryThe ENGAGES-Canada Randomized Clinical Trial

Annals of Internal Medicine

Comparative Effectiveness and Safety of Apixaban, Rivaroxaban, and Warfarin in Patients With Cirrhosis and Atrial Fibrillation: A Nationwide Cohort Study

British Medical Journal

Lee Silverman voice treatment versus NHS speech and language therapy versus control for dysarthria in people with Parkinson’s disease (PD COMM): pragmatic, UK based, multicentre, three arm, parallel group, unblinded, randomised controlled trial

 Lancet

Long-term colchicine for the prevention of vascular recurrent events in non-cardioembolic stroke (CONVINCE): a randomised controlled trial

Post-trial monitoring of a randomised controlled trial of intensive glycaemic control in type 2 diabetes extended from 10 years to 24 years (UKPDS 91)

Hemato Oncology.

Journal of Clinical Oncology

Methylphenidate Versus Placebo for Treating Fatigue in Patients With Advanced Cancer: Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial

Phase Ib Study of Unesbulin (PTC596) Plus Dacarbazine for the Treatment of Locally Recurrent, Unresectable or Metastatic, Relapsed or Refractory Leiomyosarcoma

journal of Hepatology

Using liver stiffness to predict and monitor the risk of decompensation and mortality in patients with alcohol-related liver disease

Gastroenterology

Clinical Gastroenterology

 Validation of the Laryngeal Cognitive-Affective Tool

Outcomes of High-Grade Immune Checkpoint Inhibitor Hepatitis in Hospitalized and Nonhospitalized Patients

Being Breastfed in Infancy and Risk of Colorectal Cancer and Precursor Lesions

Infectious Diseases

 Clinical Infectious Diseases

Development of Patient Safety Measures to Identify Inappropriate Diagnosis of Common Infections 

Central Nervous System Antimicrobial Exposure and Proposed Dosing for Anthrax Meningitis

Rheumatology 

  Journal of Clinical Rheumatology 

Choroidal Thickness Is a Biomarker Associated With Response to Treatment in Ankylosing Spondylitis

Arthritis and Rheumatology

Using Two Predictive Models to Capture Two Types of Poor Outcomes in Knee Arthroplasty: A Multisite Longitudinal Cohort Study

 Cardiology

 Journals of the American College of Cardiology

Effects of Rapid Uptitration of Neurohormonal Blockade on Effective,  

OCT-Guided vs Angiography-Guided Coronary Stent Implantation in Complex Lesions: An ILUMIEN IV Substudy

Endocrinology

Here are the  articles   from Journal of Clinical Endocrinology & Metabolism

Effects of Exogenous GIP and GLP-2 on Bone Turnover in Individuals With Type 2 Diabetes 

Neurology

Here are the  articles   from  Neurology

Prevalence of Suicidality in Adolescents With Newly Diagnosed Focal Epilepsy at Diagnosis and Over the Following 36 Months

Next we will be discussing articles In the field of Pulmonary and Critical care

 Chest

International Variation in Severe Exacerbation Rates in Patients With Severe Asthma

Clinician- and Patient-Identified Solutions to Reduce the Fragmentation of Post-ICU Care in Australia

 The American Journal of Respiratory and Critical Care Medicine

The Role of Neighborhood Air Pollution in Disparate Racial and Ethnic Asthma Acute Care Use

Predicting Obstructive Sleep Apnea Based on Computed Tomography Scans Using Deep Learning Models

Next we will be discussing articles In the field of Nephrology

Clinical Journal of American Society of Nephrology

Acute Kidney Injury, Systemic Inflammation, and Long-Term Cognitive Function: ASSESS-AKI

Kidney International reports

Effects of Once-Weekly Semaglutide on Kidney Disease Outcomes by KDIGO Risk Category in the SUSTAIN 6 Trial

Efficacy and Safety of Lumasiran in Patients With Primary Hyperoxaluria Type 1: Results from a Phase III Clinical Trial

Prospective Study of Change in Skin Autofluorescence Over Time and Mortality in People Receiving Hemodialysis

Etelcalcetide use During Maintenance Hemodialysis and Incidence of Parathyroidectomy After Kidney Transplantation

Hi, This Week in Medicine, we will be discussing

  New England Journal of Medicine

Combination Targeted Therapy in Relapsed Diffuse Large B-Cell Lymphoma

APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer’s Disease

Noninvasive Ventilation for Preoxygenation during Emergency Intubation

A Novel Anti-CD38 Monoclonal Antibody for Treating Immune Thrombocytopenia

 Journal of  American Medical Association

Povidone Iodine vs Chlorhexidine Gluconate in Alcohol for Preoperative Skin Antisepsis

A Randomized Clinical Trial

Dapagliflozin for Critically Ill Patients With Acute Organ Dysfunction

The DEFENDER Randomized Clinical Trial

  Annals of Internal Medicine

 Sodium–Glucose Cotransporter-2 Inhibitors and the Risk for Dialysis and Cardiovascular Disease in Patients With Stage 5 Chronic Kidney Disease

  British Medical Journal

Lateral episiotomy or no episiotomy in vacuum assisted delivery in nulliparous women (EVA): multicentre, open label, randomised controlled trial

  Journal of Clinical Oncology

Impact of Broadening Trial Eligibility Criteria on the Inclusion of Patients With Brain Metastases in Cancer Clinical Trials: Time Series Analyses for 2012-2022

 Clinical Gastroenterology

Glucagon-like Peptide-1 Receptor Agonist Use in Patients With Liver Cirrhosis and Type 2 Diabetes

Coconut Water Induces Clinical Remission in Mild to Moderate Ulcerative Colitis: Double-blind Placebo-controlled Trial

  Journal of Clinical Rheumatology 

Factors Associated With Distress Related to Perceived Dignity in Patients With Rheumatic Diseases

  Arthritis and Rheumatology

Fractures in Patients With Acute Calcium Pyrophosphate Crystal Arthritis Versus Matched Comparators in a Large Cohort Study

  Circulation

Effect of Gamification, Financial Incentives, or Both to Increase Physical Activity Among Patients at High Risk of Cardiovascular Events: The BE ACTIVE Randomized Controlled Trial

American College of Cardiology

TAVR or SAVR for Failed Bioprosthetic Aortic Valves

 Journal of Clinical Endocrinology & Metabolism

Parathyroidectomy Improves Bone Density in Women With Primary Hyperparathyroidism and Preoperative Osteopenia

 Neurology:

Cardiopulmonary Coupling Spectrogram as an Ambulatory Method for Assessing Sleep Disorders in Patients With Autoimmune Encephalitis

  Chest

Effect of Atypical Sleep EEG Patterns on Weaning From Prolonged Mechanical Ventilation

  Clinical Journal of American Society of Nephrology

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Evaluation and Measurement Properties of a Patient-Reported Experience Measure for Home Dialysis

  Kidney International reports

Lithium-Associated Kidney Failure: Predictors and Outcomes

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Hemato Oncology.

New England Journal of Medicine

Risk of Second Tumors and T-Cell Lymphoma after CAR T-Cell Therapy

Journal of Clinical Oncology

Updated Analysis of Comparative Toxicity of Proton and Photon Radiation for Prostate Cancer

Gastroenterology

 Clinical Gastroenterology

Association Between Vonoprazan and the Risk of Gastric Cancer After Helicobacter pylori Eradication

Impact of Treatment Response on Risk of Serious Infections in Patients With Crohn’s Disease: Secondary Analysis of the PYRAMID Registry

  Infectious Diseases:

From Journal of  American Medical Association

Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis

  Clinical Infectious Diseases

Development of Patient Safety Measures to Identify Inappropriate Diagnosis of Common Infections 

 Rheumatology 

  Journal of Clinical Rheumatology 

Comparative Effectiveness of Tofacitinib and Adalimumab in Axial Spondyloarthritis: A Real-World Clinical Context Multicenter Study

 Arthritis and Rheumatology

Hydroxychloroquine in Lupus Pregnancy and Risk of Preeclampsia

Cardiology

Annals of Internal Medicine

The Effect of Heat Exposure on Myocardial Blood Flow and Cardiovascular Function

British Medical Journal

Antiplatelet therapy after coronary artery bypass surgery: five year follow-up of randomised DACAB trial

Circulation

Effect of Empagliflozin on Heart Failure Outcomes After Acute Myocardial Infarction: Insights From the EMPACT-MI Trial

American College of Cardiology

Evaluate Renal Function With Semaglutide Once Weekly

Endocrinology

  Journal of Clinical Endocrinology & Metabolism

Cushing Syndrome Is Associated With Gut Microbial Dysbiosis and Cortisol-Degrading Bacteria

Neurology

  Lancet

Neurology:

Herpes Simplex Virus Encephalitis in Patients With Autoimmune Conditions or Exposure to Immunomodulatory Medications

Pulmonary and Critical care

 New England Journal of Medicine

Early Diagnosis and Treatment of COPD and Asthma — A Randomized, Controlled Trial

  American Medical Association

Dapagliflozin for Critically Ill Patients With Acute Organ Dysfunction: The DEFENDER Randomized Clinical Trial

 Chest

National and Local Direct Medical Cost Burden of COPD in the United States From 2016 to 2019 and Projections Through 2029

  Clinical Journal of American Society of Nephrology

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Protected Time for Program Administration among Nephrology Program Leadership in the United States

  Kidney International reports

Aversion to a High Salt Taste is Disturbed in Patients With CKD

Hi, This Week in Medicine, we will be discussing

 New England Journal of Medicine

Neoadjuvant Immunotherapy in Locally Advanced Mismatch Repair–Deficient Colon Cancer

Self-Expanding or Balloon-Expandable TAVR in Patients with a Small Aortic Annulus

Journal of  American Medical Association

Home Blood Pressure Telemonitoring and Nurse Case Management in Black and Hispanic Patients With Stroke

Mortality and Morbidity in Adults With Rheumatic Heart Disease

 Annals of Internal Medicine

 Lifetime Health and Economic Outcomes of Biparametric Magnetic Resonance Imaging as First-Line Screening for Prostate Cancer: A 

British Medical Journal

Mailed feedback to primary care physicians on antibiotic prescribing for patients aged 65 years and older: pragmatic, factorial randomised controlled trial

Lancet

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Journal of Clinical Oncology

Doxorubicin Exposure and Breast Cancer Risk in Survivors of Adolescent and Adult Hodgkin Lymphoma

Clinical Gastroenterology

 Efficacy and Safety of Vonoprazan-Amoxicillin Dual Regimen With Varying Dose and Duration for Helicobacter pylori Eradication: A Multicenter, Prospective, Randomized Study

Chronic Viral Hepatitis B and C Outweigh MASLD in the Associated Risk of Cirrhosis and HCC

Journal of Clinical Rheumatology 

Axial Spondyloarthritis: Does Magnetic Resonance Imaging Classification Improve Report Interpretation

Arthritis and Rheumatology

Screening of Environmental Chemicals to Characterize Exposures in Participants With Systemic Lupus Erythematosus

Circulation

Clinical Impact of Routine Assessment of Patient-Reported Health Status in Heart Failure Clinic: The PRO-HF Trial

American College of Cardiology

Degenerative MR Due to Flail Leaflet According to Sex

Journal of Clinical Endocrinology & Metabolism

Orthostatic Hypotension Promotes the Progression From Mild Cognitive Impairment to Dementia in Type 2 Diabetes Mellitus 

Neurology:

Effect of Endovascular Thrombectomy for Acute Ischemic Stroke on Cognitive Outcomes: A Secondary Analysis of the ESCAPE Trial

Chest

Safety and Efficacy of Clofazimine as an Alternative for Rifampicin in Mycobacterium avium Complex Pulmonary Disease Treatment

Comparison of Pirfenidone and Nintedanib

Clinical Journal of American Society of Nephrology

Preventive Pharmacological Therapy and Risk of Recurrent Urinary Stone Disease

Kidney International reports

Effectiveness of Molnupiravir and Nirmatrelvir-Ritonavir in CKD Patients With COVID-19

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New England Journal of Medicine

Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy

Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke

 Journal of  American Medical Association

Aspirin vs Placebo as Adjuvant Therapy for Breast CancerThe Alliance A011502 Randomized Trial

Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine ReplacementA Randomized Clinical Trial

 Annals of Internal Medicine

Efficacy of Voluntary Medical Male Circumcision to Prevent HIV Infection Among Men Who Have Sex With Men

Benefits and Risks Associated With Statin Therapy for Primary Prevention in Old and Very Old Adults

  British Medical Journal

Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first line treatment for advanced gastric or gastro-oesophageal junction adenocarcinoma

Epidural analgesia during labour and severe maternal morbidity

  Journal of Clinical Oncology

Impact of Helicobacter pylori Infection and Treatment on Colorectal Cancer in a Large, Nationwide Cohort

 journal of Hepatology

Primary hypocholesterolemia is associated with an increased risk of hepatic complications in the general population

 Clinical Gastroenterology

 Validated Clinical Score to Predict Gastroesophageal Reflux in Patients With Chronic Laryngeal Symptoms: COuGH RefluX

Hypercholesterolemia Is Associated With Dysregulation of Lipid Metabolism and Poor Prognosis in Primary Biliary Cholangitis

  Journal of Clinical Rheumatology 

Choroidal Thickness Is a Biomarker Associated With Response to Treatment in Ankylosing Spondylitis

  Arthritis and Rheumatology

Effect of Recent Antirheumatic Drug on Features of Rheumatoid Arthritis–Associated Lymphoproliferative Disorders

 Circulation

Comparison of Incidence and Prognostic Impact of Ischemic, Major Bleeding and Heart Failure Events in Patients With Chronic Coronary Syndrome: Insights From the CORONOR Registry

American College of Cardiology

Coronary Atherosclerotic Plaque Activity and Risk of MI

  Journal of Clinical Endocrinology & Metabolism

Insufficient Bone Mineralization to Sustain Mechanical Load of Weight in Obese Boys: A Cross-Sectional Study 

 Neurology:

Distribution of Silent Cerebral Infarcts in Adults With Sickle Cell Disease

  Chest

Tolerability Outcomes of American Thoracic Society/Infectious Diseases Society of America Guideline-Recommended Multidrug Antibiotic Treatment for Mycobacterium avium Complex Pulmonary Disease in US Medicare Beneficiaries With Bronchiectasis

Prophylactic Minocycline for Delirium in Critically Ill Patients

 Clinical Journal of American Society of Nephrology

Sotagliflozin and Kidney Outcomes, Kidney Function, and Albuminuria in Type 2 Diabetes and CKD: A Secondary Analysis of the SCORED Trial

 Kidney International reports

Pregnancy and Family Planning in Women With Kidney Disease

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 Journal of  American Medical Association

Hypertension and Kidney Function After Living Kidney Donation

Hypertension and Kidney Function After Living Kidney Donation

  Annals of Internal Medicine

Association Between Autoimmune Diseases and Monoclonal Gammopathy of Undetermined Significance

Artificial Intelligence for Real-Time Prediction of the Histology of Colorectal Polyps by General Endoscopists

 British Medical Journal

Epidural analgesia during labour and severe maternal morbidity

 Clinical Gastroenterology

Older Patients With Acute on Chronic Liver Failure Have a Higher Waitlist Mortality, but Acceptable Post Liver Transplantation Survival When Compared to Younger Patients

Prolonged Gastrointestinal Manifestations After Recovery From COVID-19

 Clinical Infectious Diseases

External Validation of the 2023 Duke–International Society for Cardiovascular Infectious Diseases Diagnostic Criteria for Infective Endocarditis

  Journal of Clinical Rheumatology 

Rheumatology High Blood Pressure Protocol Reduces Disparities, But Delays Remain for External Primary Care

 Journals of the American College of Cardiology

Mandibular Advancement vs CPAP for Blood Pressure Reduction in Patients With Obstructive Sleep Apnea

 Journal of Clinical Endocrinology & Metabolism

Erythrocytosis Is Rare With Exogenous Testosterone in Gender-Affirming Hormone Therapy

 Chest

Ozanimod Therapy in Patients With COVID-19 Requiring Oxygen Support

The Association Between Prepandemic ICU Performance and Mortality Variation in COVID-19

 Clinical Journal of American Society of Nephrology

Phase 2 Trial of Cemdisiran in Adult Patients with IgA Nephropathy: A Randomized Controlled Trial

Evaluating ApoL1 Genetic Testing Policy Options for Transplant Centers: A Delphi Consensus Panel Project with Stakeholders

  Kidney International reports

Pregnancy and Family Planning in Women With Kidney Disease

Lithium-Associated Kidney Failure: Predictors and Outcomes

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Andexanet for Factor Xa Inhibitor–Associated Acute Intracerebral Hemorrhage

Perioperative Nivolumab in Resectable Lung Cancer

Olezarsen for Hypertriglyceridemia in Patients at High Cardiovascular Risk

Olezarsen, Acute Pancreatitis, and Familial Chylomicronemia Syndrome

  Journal of  American Medical Association

Text Messages With Financial Incentives for Men With Obesity

A Randomized Clinical Trial

An Adaptive Behavioral Intervention for Weight Loss Management

A Randomized Clinical Trial

 Nature Medicine

Effectiveness of Bariatric Metabolic Surgery versus Glucagon-Like Peptide-1 Receptor Agonists for prevention of Congestive Heart Failure

 Lancet

Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention in acute coronary syndromes (IVUS-ACS): a two-stage, multicentre, randomised trial

  Journal of Clinical Oncology

Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women

  journal of Hepatology

Optimal hepatitis C treatment adherence patterns and sustained virologic response among people who inject drugs: The HERO study

Background & Aims

  Clinical Gastroenterology

 Prospective Comparison of Attenuation Imaging and Controlled Attenuation Parameter for Liver Steatosis Diagnosis in Patients With Nonalcoholic Fatty Liver Disease and Type 2 Diabetes

Misclassified Alcohol-related Liver Disease is Common in Presumed Metabolic Dysfunction-associated Steatotic Liver Disease and Highly Increases Risk for Future Cirrhosis

Burden of Crohn’s Disease in the United States Medicaid Population, 2010–2019

 Clinical Infectious Diseases

 The Utility of Risk Factors to Define Complicated Staphylococcus aureus Bacteremia in a Setting With Low Methicillin-Resistant S. aureus Prevalence

Outcomes of SARS-CoV-2 Omicron Variant Infections Compared With Seasonal Influenza and Respiratory Syncytial Virus Infections in Adults Attending the Emergency Department: A Multicenter Cohort Study

Evaluation of the 2023 Duke-International Society of Cardiovascular Infectious Diseases Criteria in a Multicenter Cohort of Patients With Suspected Infective Endocarditis 

 Journal of Clinical Rheumatology 

The Relationship Between Anti–SSA-52 and Interstitial Lung Disease

Risk Factors for Pneumocystis jirovecii Pneumonia in Children With Systemic Lupus Erythematosus Exposed to Prolonged High-Dose Glucocorticoids

 Arthritis and Rheumatology

Using Polygenic Risk Scores to Aid Diagnosis of Patients With Early Inflammatory Arthritis: Results From the Norfolk Arthritis Register

  Circulation

Directed Differentiation of Human Induced Pluripotent Stem Cells to Heart Valve Cells

American College of Cardiology

Cardiomyopathies in Children and Adolescents

 Journals of the American College of Cardiology

Association of Lipoprotein(a) Levels With Myocardial Infarction in Patients With Low-Attenuation Plaque

 Journal of Clinical Endocrinology & Metabolism

Characterizing Genetic Alterations Related to Radioiodine Avidity in Metastatic Thyroid Cancer

Defective Visceral Adipose Tissue Adaptation in Gestational Diabetes Mellitus

Next we will be discussing articles  from Neurology:

Covert Cerebrovascular Changes in People With Heart Disease: A Systematic Review and Meta-Analysis

  Chest

Longitudinal Effects of Elexacaftor/Tezacaftor/Ivacaftor

Etiology-Based Prognosis of Extracorporeal CPR Recipients After Out-of-Hospital Cardiac Arrest

  The American Journal of Respiratory and Critical Care Medicine

Commensal Oral Microbiota, Disease Severity, and Mortality in Fibrotic Lung Disease

Alveolar Hemorrhage in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Results of an International Randomized Controlled Trial (PEXIVAS)

  Clinical Journal of American Society of Nephrology

Histologic and Clinical Factors Associated with Kidney Outcomes in IgA Vasculitis Nephritis

Associations of Changes in Bone Turnover Markers with Change in Bone Mineral Density in Kidney Transplant Patients

Kidney International reports

Associations Between Prematurity, Birthweight, and Adolescence Blood Pressure in a Nationwide Cohort

A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General Population

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Exagamglogene Autotemcel for Severe Sickle Cell Disease

Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia

Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size

 Journal of  American Medical Association

Ponatinib vs Imatinib in Frontline Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

Associations of Internal Medicine Residency Milestone Ratings and Certification Examination Scores With Patient Outcomes

Annals of Internal Medicine

The Safety of Outpatient Health Care: Review of Electronic Health Records

Diagnostic Strategy Using Color Doppler Ultrasound of Temporal Arteries in Patients With High Clinical Suspicion of Giant Cell Arteritis: A Prospective Cohort Study

Nature Medicine

Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis

Lancet

Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT): a multicentre, open-label, randomised controlled trial

Journal of Clinical Oncology

Phase II Trial of nab-Sirolimus in Patients With Advanced Malignant Perivascular Epithelioid Cell Tumors (AMPECT): Long-Term Efficacy and Safety Update

 journal of Hepatology

Clinical profiles and mortality rates are similar for metabolic dysfunction-associated steatotic liver disease and non-alcoholic fatty liver disease

Molecular force-induced liberation of transforming growth factor-beta remodels the spleen for ectopic liver regeneration

Clinical Gastroenterology

Type 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment

Screening for Fibrosis Promotes Lifestyle Changes: A Prospective Cohort Study in 4796 Individuals

ENTERPRET: A Randomized Controlled Trial of Vedolizumab Dose Optimization in Patients With Ulcerative Colitis Who Have Early Nonresponse

  Clinical Infectious Diseases

Impact of a Purified Microbiome Therapeutic on Abundance of Antimicrobial Resistance Genes in Patients With Recurrent Clostridioides difficile Infection

A Systematic Review of Predictor Composition, Outcomes, Risk of Bias, and Validation of COVID-19 Prognostic Scores

Compared Performance of the 2023 Duke–International Society for Cardiovascular Infectious Diseases, 2000 Modified Duke, and 2015 European Society of Cardiology Criteria for the Diagnosis of Infective Endocarditis in a French Multicenter Prospective Cohort

 Journal of Clinical Rheumatology 

Measurement of Neutrophil Extracellular Traps as a Biomarker for the Differential Diagnosis Between Antineutrophil Cytoplasmic Antibody–Positive Individuals With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis and Nonautoimmune Diseases

Prediction of Treatment Effect of SLE-ITP Patients Based on Cost-Sensitive Neural Network and Variational Autoencoder

  Arthritis and Rheumatology

Anti-Inflammatory Effect of High-Density Lipoprotein Blunted by Delivery of Altered MicroRNA Cargo in Patients With Rheumatoid Arthritis

American College of Cardiology

LGE CMR and Sudden Death in Hypertrophic Cardiomyopathy 

 Journals of the American College of Cardiology

Sacubitril/Valsartan-Related Hypotension in Patients With Heart Failure and Preserved or Mildly Reduced Ejection Fraction

 Journal of Clinical Endocrinology & Metabolism

Association Between a History of Breast Cancer and Decreased Thyroid Cancer-specific Mortality

Neurology:

Association of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort

Chest

Symptoms and Impaired Quality of Life After COVID-19 Hospitalization: Effect of Therapeutic Heparin in Non-ICU Patients in the Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 Acute Trial

Use and Outcomes of Peripheral Vasopressors in Early Sepsis-Induced Hypotension Across Michigan Hospitals

  The American Journal of Respiratory and Critical Care Medicine

Zinpentraxin Alfa for Idiopathic Pulmonary Fibrosis: The Randomized Phase III STARSCAPE Trial

  Clinical Journal of American Society of Nephrology

Associations of Angiopoietin 2 and Vascular Endothelial Growth Factor-A Concentrations with Clinical End Points

The Association of Intra-Abdominal Adhesions with Peritoneal Dialysis Catheter-Related Complications

Kidney International reports

Early Rituximab as an Add-On Therapy in Children With the Initial Episode of Nephrotic Syndrome

Aversion to a High Salt Taste is Disturbed in Patients With CKD