This Week In Medicine

Hi, This Week in Medicine, we will be discussing

 New England Journal of Medicine

Highly Pathogenic Avian Influenza A(H5N1) Virus Infections in Humans

Embolization of the Middle Meningeal Artery for Chronic Subdural Hematoma

Oral Infigratinib Therapy in Children with Achondroplasia

 Journal of  American Medical Association

First-Line Sugemalimab Plus Chemotherapy for Advanced Gastric Cancer: The GEMSTONE-303 Randomized Clinical Trial

Medicaid Spending and Health-Related Social Needs in the North Carolina Healthy Opportunities Pilots Program

 Annals of Internal Medicine

Glucagon-Like Peptide-1 Receptor Agonists and Risk for Depression in Older Adults With Type 2 Diabetes: A Target Trial Emulation Study

  British Medical Journal

Glucagon-like peptide-1 receptor agonists and risk of suicidality among patients with type 2 diabetes: active comparator, new user cohort study

  Lancet

Endoscopic, ultrasound-guided, radiofrequency ablation of aldosterone-producing adenomas (FABULAS): a UK, multicentre, prospective, proof-of-concept trial

  Journal of Clinical Oncology

Nodal Burden and Oncologic Outcomes in Patients With Residual Isolated Tumor Cells After Neoadjuvant Chemotherapy

 journal of Hepatology

Variation in intention-to-treat survival by MELD subtypes: All models created for end-stage liver disease are not equal

 Clinical Gastroenterology

Meta-Analysis of Endoscopic Full-Thickness Resection Versus Endoscopic Submucosal Dissection for Complex Colorectal Lesions

  Rheumatology 

A Randomized Controlled Trial of Efficacy and Safety of Fecal Microbiota Transplant for Preventing Recurrent Clostridioides difficileInfection

 Journal of Clinical Rheumatology 

Circulation

Arterial-Lymphatic-Like Endothelial Cells Appear in Hereditary Hemorrhagic Telangiectasia 2 and Contribute to Vascular Leakage and Arteriovenous Malformations

 Journals of the American College of Cardiology

Intensive Lifestyle Intervention, Cardiac Biomarkers, and Cardiovascular Outcomes in Diabetes: Look AHEAD Cardiac Biomarker Ancillary Study

  JAMA Cardiology

Interpreting Population Mean Treatment Effects in the Kansas City Cardiomyopathy QuestionnaireA Patient-Level Meta-Analysis

  Journal of Clinical Endocrinology & Metabolism

Clinical and Biochemical Data for the Diagnosis of Endogenous Hypercortisolism: The “Cushingomic” Approach

 Neurology

Utility of Progression Independent of Relapse Activity as a Trial Outcome in Relapsing-Remitting Multiple Sclerosis

  Chest

The Responsiveness of Exercise Tests in COPD

A Randomized Controlled Trial

 The American Journal of Respiratory and Critical Care Medicine

Humidified Noninvasive Ventilation versus High-Flow Therapy to Prevent Reintubation in Patients with Obesity: A Randomized Clinical Trial

 Clinical Journal of American Society of Nephrology

Efficacy and Safety of Admilparant, an LPA1 Antagonist, in Pulmonary Fibrosis: A Phase 2 Randomized Clinical Trial

  Kidney International reports

Impact of Different CKD Definitions on Long-Term Renal Function and Mortality in a Population-Based Cohort Study

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Catheter Ablation or Antiarrhythmic Drugs for Ventricular Tachycardia

Fixed-Duration Acalabrutinib Combinations in Untreated Chronic Lymphocytic Leukemia

Microvascular Inflammation of Kidney Allografts and Clinical Outcomes

Long-Term Effects of Empagliflozin in Patients with Chronic Kidney Disease

 Journal of  American Medical Association

Emergency Clinician Buprenorphine Initiation, Subsequent Prescriptions, and Continuous Prescriptions

Illicit Substance Use and Treatment Access Among Adults Experiencing Homelessness

  Annals of Internal Medicine

Effects of Noise and Public Setting on Blood Pressure Readings: A Randomized Crossover Trial

The Association of Epstein–Barr Virus Donor and Recipient Serostatus With Outcomes After Kidney Transplantation: A Retrospective Cohort Study

  British Medical Journal

Stroke and myocardial infarction with contemporary hormonal contraception: real-world, nationwide, prospective cohort study

  Lancet

Epidemiological and clinical features of mpox during the clade Ib outbreak in South Kivu, Democratic Republic of the Congo: a prospective cohort study

 journal of Hepatology

Identifying the optimal measurement timing and hemodynamic targets of portal pressure gradient after TIPS in patients with cirrhosis and variceal bleeding

 Gastroenterology

Safety and Tolerability of CP101, a Full-Spectrum, Oral Microbiome Therapeutic for the Prevention of Recurrent Clostridioides difficile Infection: A Phase 2 Randomized Controlled Trial

 Clinical Gastroenterology

 Prevalence and Predictors of Follow-up Endoscopic Biopsy in Patients With Celiac Disease in the United States

 Clinical Infectious Diseases

PUNCH CD3-OLS: A Phase 3 Prospective Observational Cohort Study to Evaluate the Safety and Efficacy of Fecal Microbiota, Live-jslm (REBYOTA) in Adults With Recurrent Clostridioides difficile Infection

 Arthritis and Rheumatology

Clinical Presentation and Course of Pulmonary Involvement in Chronic Nonbacterial Osteomyelitis

  Circulation

Conduction Disturbances and Outcome After Surgical Aortic Valve Replacement in Patients With Bicuspid and Tricuspid Aortic Stenosis

 Journals of the American College of Cardiology

Accelerometer-Measured Sedentary Behavior and Risk of Future Cardiovascular Disease

  JAMA Cardiology

Coronary Revascularization Guided With Fractional Flow Reserve or Instantaneous Wave-Free RatioA 5-Year Follow-Up of the DEFINE FLAIR Randomized Clinical Trial

 Journal of Clinical Endocrinology & Metabolism

Gut Microbial Changes Associated With Obesity in Youth With Type 1 Diabetes 

  Diabetes care

Intensive Glucose Lowering and Its Effects on Vascular Events and Death According to Age at Diagnosis and Duration of Diabetes: The ADVANCE Trial 

   Neurology

Effects of COVID-19 Infection on Symptom Severity and Disability in Multiple Sclerosis

Infections, including infection with SARS-CoV-2 (COVID-19), could alter the course of multiple sclerosis (MS). Previous studies assessing the  Chest

longitudinal Changes in Maximal Forced Inspiratory Flow and Clinical Outcomes in Patients With COPD

The American Journal of Respiratory and Critical Care Medicine

Serum Immunoglobulin G Levels Are Associated with Risk for Exacerbations: An Analysis of SPIROMICS

 Clinical Journal of American Society of Nephrology

Humidified Noninvasive Ventilation versus High-Flow Therapy to Prevent Reintubation in Patients with Obesity: A Randomized Clinical Trial

  Kidney International reports

Randomized Trial of Dietary Acid Reduction and Acid-Base Status of Patients With CKD and Normal Estimated GFR

CKD in Bardet-Biedl Syndrome: Evidence Supporting Multifactorial Etiology

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New England Journal of Medicine

Colchicine in Acute Myocardial Infarction

Routine Spironolactone in Acute Myocardial Infarction

Phase 3 Trial of Cabozantinib to Treat Advanced Neuroendocrine Tumors

Evolving Epidemiology of Mpox in Africa in 2024

 Journal of  American Medical Association

US Abortion Bans and Fertility

  Annals of Internal Medicine

Effectiveness of the 2023-to-2024 XBB.1.5 COVID-19 Vaccines Over Long-Term Follow-up: A Target Trial Emulation

 British Medical Journal

Stroke and myocardial infarction with contemporary hormonal contraception: real-world, nationwide, prospective cohort study

  Lancet

Life expectancy losses in the Gaza Strip during the period October, 2023, to September, 2024

 Journal of Clinical Oncology

Trastuzumab Duocarmazine in Pretreated Human Epidermal Growth Factor Receptor 2–Positive Advanced or Metastatic Breast Cancer: An Open-Label, Randomized, Phase III Trial (TULIP)

  journal of Hepatology

PegIFN alpha-2a reduces relapse in HBeAg-negative patients after nucleo(s)tide analogue cessation: A randomized-controlled trial

 Gastroenterology

Multimodal Profiling of Peripheral Blood Identifies Proliferating Circulating Effector CD4+ T Cells as Predictors for Response to Integrin α4β7–Blocking Therapy in Inflammatory Bowel Disease

 Clinical Gastroenterology

Endoscopic Submucosal Dissection Criteria for Differentiated-type Early Gastric Cancer Are Applicable to Mixed-type Differentiated Predominant

 Clinical Infectious Diseases

Oral Versus Intravenous Antibiotic Therapy for Staphylococcus aureusBacteremia or Endocarditis: A Systematic Review and Meta-Analysis of Randomized, Controlled Trials

 Arthritis and Rheumatology

Social Connections in Older Adults With Systemic Lupus Erythematosus: Patient Perspectives

  Circulation

A Proteomics-Based Approach for Prediction of Different Cardiovascular Diseases and Dementia

 Journals of the American College of Cardiology

Higher Aircraft Noise Exposure Is Linked to Worse Heart Structure and Function by Cardiovascular MRI

 JAMA Cardiology

Cerebral Embolic Protection by Geographic RegionA Post Hoc Analysis of the PROTECTED TAVR Randomized Clinical Trial

 Journal of Clinical Endocrinology & Metabolism

The Association Between Thyroid Differentiation Score and Survival Outcomes in Papillary Thyroid Carcinoma

  Diabetes care

Osteoprotegerin, Osteopontin, and Osteocalcin Are Associated With Cardiovascular Events in Type 2 Diabetes: Insights From EXSCEL

 Neurology

Chemotherapy-Related Cognitive Impairment and Changes in Neural Network Dynamics: A Systematic Review

  Chest

Clinical Characteristics and Prognosis of Patients With Severe Pneumonia With Pneumocystis jirovecii Colonization

A Multicenter, Retrospective Study

 The American Journal of Respiratory and Critical Care Medicine

Effect of Triple Therapy on Cardiovascular and Severe Cardiopulmonary Events in Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of a Randomized, Double-Blind, Phase 3 Clinical Trial (ETHOS)

 Clinical Journal of American Society of Nephrology

Effect of Triple Therapy on Cardiovascular and Severe Cardiopulmonary Events in Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of a Randomized, Double-Blind, Phase 3 Clinical Trial (ETHOS)

 Kidney International reports

Cost-Effectiveness of Clinical Decision Support to Improve CKD Outcomes Among First Nations Australians

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Alternative Complement Pathway Inhibition with Iptacopan in IgA Nephropathy

Atrasentan in Patients with IgA Nephropathy

Efficacy of Zenocutuzumab in NRG1 Fusion–Positive Cancer

 Journal of  American Medical Association

Simvastatin and Rifaximin in Decompensated Cirrhosis

A Randomized Clinical Trial

Age and Sex Differences in Efficacy of Treatments for Type 2 Diabetes

A Network Meta-Analysis

  Annals of Internal Medicine

Effectiveness and Cost-Effectiveness of Expanded Targeted Testing and Treatment of Latent Tuberculosis Infection Among the Medicare Population in 2022

 British Medical Journal

Frozen versus fresh embryo transfer in women with low prognosis for IVF treatment

 Lancet

Traumatic injury mortality in the Gaza Strip from Oct 7, 2023, to June 30, 2024: a capture–recapture analysis

  Journal of Clinical Oncology

OPAR: A Randomized Trial of Partial Breast Irradiation in Five Fractions Once Daily for Early Breast Cancer

  Hepatology

ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH

 Gastroenterology

Obesity-Facilitated Colon Cancer Progression Is Mediated by Increased Diacylglycerol O-Acyltransferases 1 and 2 Levels

 Clinical Gastroenterology

Satisfaction With and Adherence to Off-Label Corticosteroids in Adolescents and Adults With Eosinophilic Esophagitis: Results of a Web-Based Survey in the United States

 Clinical Infectious Diseases

Antibiotic Prescribing for Respiratory Tract Infections in Urgent Care: A Comparison of In-Person and Virtual Settings

  Rheumatology 

Use of 18F-fluorodeoxyglucose Positron Emission Tomography to Monitor Disease Activity in Patients With Giant Cell Arteritis on Tocilizumab

 Journal of Clinical Rheumatology 

 Nationwide Analysis of Variables Associated With Sarcoid Inpatient Mortality

Circulation

Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism: Primary Results of the PEERLESS Randomized Controlled Trial

 Journals of the American College of Cardiology

Secondary Prevention Medications in 17 Countries Grouped by Income Level (PURE): A Prospective Cohort Study

 JAMA Cardiology

Microaxial Flow Pump Hemodynamic and Metabolic Effects in Infarct-Related Cardiogenic ShockA Substudy of the DanGer Shock Randomized Clinical Trial

Insulin Sensitivity and Insulin Secretion in Adults With Friedreich's Ataxia: The Role of Skeletal Muscle 

 Diabetes care

Large Language Model GPT-4 Compared to Endocrinologist Responses on Initial Choice of Glucose-Lowering Medication Under Conditions of Clinical Uncertainty

 Neurology

Effect of IV Thrombolysis With Alteplase in Patients With Vessel Occlusion in the WAKE-UP Trial

  Chest

A 1-Year Weight Management Program for Difficult-to-Treat Asthma With Obesity

A Randomized Controlled Study

The American Journal of Respiratory and Critical Care Medicine

Type 1 Immune Responses Related to Viral Infection Influence Corticosteroid Response in Asthma

 Clinical Journal of American Society of Nephrology

Medication Burden and Adverse Cardiovascular Events and Death in Patients Treated with Maintenance Hemodialysis: A Nationwide Cohort Study

 Kidney International reports

Implementation of a Kidney Genetic Service Into the Diagnostic Pathway for Patients With Chronic Kidney Disease in Canada

 clinical utility, strategies to reduce the time from CKD diagnosis to genetics assessment are needed.

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity

Continuation versus Interruption of Oral Anticoagulation during TAVI

Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A

CRISPR-Based Therapy for Hereditary Angioedema

  Journal of  American Medical Association

Health System, Community-Based, or Usual Dementia Care for Persons With Dementia and Caregivers

Palliative Care Program for Community-Dwelling Individuals With Dementia and Caregivers

The IN-PEACE Randomized Clinical Trial

 Annals of Internal Medicine

The Association of Epstein–Barr Virus Donor and Recipient Serostatus With Outcomes After Kidney Transplantation

 British Medical Journal

Frozen versus fresh embryo transfer in women with low prognosis for in vitro fertilisation treatment: pragmatic, multicentre, randomised controlled trial

  Lancet

Coronary CT angiography-guided management of patients with stable chest pain: 10-year outcomes from the SCOT-HEART randomised controlled trial in Scotland

 Journal of Clinical Oncology

Incidence of Medication-Related Osteonecrosis of the Jaw in Patients With Breast Cancer During a 20-Year Follow-Up: A Population-Based Multicenter Retrospective Study

 journal of Hepatology

Patient-reported outcomes in chronic hepatitis delta: An exploratory analysis of the phase III MYR301 trial of bulevirtide

 outcome following liver transplantation of patients with ACLF grade 3

  Gastroenterology

Myosin Vb Traffics P-Glycoprotein to the Apical Membrane of Intestinal Epithelial Cells

 Clinical Gastroenterology

 Prevalence and Predictors of Follow-up Endoscopic Biopsy in Patients With Celiac Disease in the United States

Do Patients With NASH-related Cirrhosis Have Better Overall Survival Compared With Other Etiologies of Cirrhosis? A Population-based Study

  Rheumatology 

Associations of fire smoke and other pollutants with incident rheumatoid arthritis and rheumatoid arthritis‐associated interstitial lung disease

 Circulation

Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial

  Journals of the American College of Cardiology

Machine Learning-Based Prediction of Death and Hospitalization in Patients With Implantable Cardioverter Defibrillators

  JAMA Cardiology

Artificial Intelligence–Enhanced Electrocardiography for Prediction of Incident Hypertension

 Journal of Clinical Endocrinology & Metabolism

Causal Association Between BMI and Polycystic Ovarian Syndrome: Bidirectional 2-Sample Mendelian Randomization Study

 Diabetes care

Glycemic and Psychosocial Outcomes of Advanced Hybrid Closed-Loop Therapy in Youth With High HbA1c: A Randomized Clinical Trial

 Chest

Longitudinal Changes in Maximal Forced Inspiratory Flow and Clinical Outcomes in Patients With COPD

 The American Journal of Respiratory and Critical Care Medicine

Toll-like Receptor 9 Inhibition Mitigates Fibroproliferative Responses in Translational Models of Pulmonary Fibrosis

 Clinical Journal of American Society of Nephrology

Sodium-Glucose Cotransporter 2 Inhibitors and Kidney Outcomes across the Spectrum of Kidney Disease: A Systematic Review and Meta-Analysis

Cost-Effectiveness of Empagliflozin in CKD with or without Albuminuria

 Kidney International reports

Randomized Trial Demonstrating No Translocation of Intact Intestinal Bacteria During Hemodialysis or Hemodiafiltration

Hi, This Week in Medicine, we will be discussing

 New England Journal of Medicine

Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer

A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest

Intraosseous or Intravenous Vascular Access for Out-of-Hospital Cardiac Arrest

Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation

 Journal of  American Medical Association

Transanal vs Laparoscopic Total Mesorectal Excision and 3-Year Disease-Free Survival in Rectal Cancer: The TaLaR Randomized Clinical Trial

Question  Is transanal total mesorectal excision (TME) noninferior to laparoscopic   Annals of Internal Medicine

Census Tract Rurality, Predominant Race and Ethnicity, and Distance to Lung Cancer Screening Facilities

Assessing the Risk for Falls in Older Adults After Initiating Gabapentin Versus Duloxetine

 British Medical Journal

Dapagliflozin plus calorie restriction for remission of type 2 diabetes

  Lancet

Transarterial chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study

 Journal of Clinical Oncology

Efficacy and Safety of Roxadustat for Anemia in Patients Receiving Chemotherapy for Nonmyeloid Malignancies: A Randomized, Open-Label, Active-Controlled Phase III Study

  journal of Hepatology

Induction of steatosis in primary human hepatocytes recapitulates key pathophysiological aspects of metabolic dysfunction-associated steatotic liver disease

Functional cure of hepatitis B in patients with cancer undergoing immune checkpoint inhibitor therapy

 Gastroenterology

Glutamine Supplementation as a Novel Metabolic Therapeutic Strategy for LIG3-Dependent Chronic Intestinal Pseudo-Obstruction

 Clinical Gastroenterology

 Endoscopic Submucosal Dissection Criteria for Differentiated-type Early Gastric Cancer Are Applicable to Mixed-type Differentiated Predominant

Association Between Different Types of Physical Activity and Hepatic Steatosis and Liver Fibrosis: A Cross-Sectional Study Based on NHANES

  Journal of Clinical Rheumatology 

Preliminary Evaluation for the Development of a Scoring System to Predict Homozygous M694V Genotype in Familial Mediterranean Fever Patients: A Single-Center Study

 Circulation

A Rare Noncoding Enhancer Variant in SCN5A Contributes to the High Prevalence of Brugada Syndrome in Thailand

   Journals of the American College of Cardiology

Optimal Strategy for Complete Revascularization in ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A Network Meta-Analysis

  JAMA Cardiology

Cost-Effectiveness of a Polypill for Cardiovascular Disease Prevention in an Underserved Population

  Journal of Clinical Endocrinology & Metabolism

Personalized Medicine in Acromegaly: The ACROFAST Study 

 Diabetes care

Diabetes Overtreatment and Hypoglycemia in Older Patients With Type 2 Diabetes on Insulin Therapy: Insights From the HYPOAGE Cohort Study

  Chest

Neutrophil-Mediated Inflammatory Plasminogen Degradation, Rather Than High Plasminogen-Activator Inhibitor-1, May Underly Failures and Inefficiencies of Intrapleural Fibrinolysis

 The American Journal of Respiratory and Critical Care Medicine

Lung Transcriptomics Link Emphysema to Barrier Dysfunction and Macrophage Subpopulations

 Clinical Journal of American Society of Nephrology

Fracture in Association with Anticoagulant Therapy in Patients with CKD and Atrial Fibrillation

Albuminuria and Rapid Kidney Function Decline as Selection Criteria for Kidney Clinical Trials in Type 1 Diabetes Mellitus

 Kidney International reports

Muscle Mass, Muscle Strength, and Health-Related Quality of Life in Kidney Transplant Recipients

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis

APOL1 Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans

Fracture Prevention with Infrequent Zoledronate in Women 50 to 60 Years of Age

Survival with Trastuzumab Emtansine in Residual HER2-Positive Breast Cancer

 Journal of  American Medical Association

Intra-Arterial Tenecteplase Following Endovascular Reperfusion for Large Vessel Occlusion Acute Ischemic Stroke: The POST-TNK Randomized Clinical Trial

Intra-Arterial Urokinase After Endovascular Reperfusion for Acute Ischemic Stroke: The POST-UK Randomized Clinical Trial

 Annals of Internal Medicine

Inequities in Distance to Lung Cancer Screening Programs

  British Medical Journal

Time to nursing home admission and death in people with dementia

  Lancet

Efficacy, safety, and target engagement of dazukibart, an IFNβ specific monoclonal antibody, in adults with dermatomyositis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

  Journal of Clinical Oncology

Association of Participation in Medicare's Oncology Care Model With Spending, Utilization, and Quality Outcomes Among Commercially Insured and Medicare Advantage Members

  journal of Hepatology

Effect of pemvidutide, a GLP-1/glucagon dual receptor agonist, on MASLD: A randomized, double-blind, placebo-controlled study

Neuropilin-1 is a novel host factor modulating the entry of hepatitis B virus

 Gastroenterology

Unveiling Cancer-Related Metaplastic Cells in Both Helicobacter pylori Infection and Autoimmune Gastritis

  Clinical Gastroenterology

 Satisfaction With and Adherence to Off-Label Corticosteroids in Adolescents and Adults With Eosinophilic Esophagitis: Results of a Web-Based Survey in the United States

Meta-Analysis of Endoscopic Full-Thickness Resection Versus Endoscopic Submucosal Dissection for Complex Colorectal Lesions

 Rheumatology 

Altered Protein Structures and Neoepitopes in Lupus Neutrophils From Dysregulated Splicing of Messenger RNA

  Journal of Clinical Rheumatology 

Nationwide Analysis of Variables Associated With Sarcoid Inpatient Mortality

    Circulation

Sickle Trait and Alpha Thalassemia Increase NOS-Dependent Vasodilation of Human Arteries Through Disruption of Endothelial Hemoglobin-eNOS Interactions

 Journals of the American College of Cardiology

Drug-Coated Balloon Angioplasty of the Side Branch During Provisional Stenting: The Multicenter Randomized DCB-BIF Trial

Aspirin and Hemocompatibility After LVAD Implantation in Patients With Atherosclerotic Vascular Disease

A Secondary Analysis From the ARIES-HM3 Randomized Clinical Trial

  Journal of Clinical Endocrinology & Metabolism

Regional Adiposity and Insulin Sensitivity—Interactions With Menopause and HIV in Middle-Aged Black African Women

  Diabetes care

Combination SGLT2 Inhibitor and Glucagon Receptor Antagonist Therapy in Type 1 Diabetes: A Randomized Clinical Trial 

Here are the  articles   from  Chest

Clinical Characteristics and Prognosis of Patients With Severe Pneumonia With Pneumocystis jirovecii Colonization

Here are the  articles   from The American Journal of Respiratory and Critical Care Medicine

Proteomic Risk Score of Increased Respiratory Susceptibility: A Multicohort Study.

 Clinical Journal of American Society of Nephrology

Surrogate End Points in Apolipoprotein L1–Associated Kidney Disease: Evaluation in Three Cohorts

Medication Burden and Adverse Cardiovascular Events and Death in Patients Treated with Maintenance Hemodialysis: A Nationwide Cohort Study

Kidney International reports

Outcome of Patients Transplanted for C3 Glomerulopathy and Primary Immune Complex-Mediated Membranoproliferative Glomerulonephritis

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Transcatheter Valve Replacement in Severe Tricuspid Regurgitation

Plozasiran for Managing Persistent Chylomicronemia and Pancreatitis Risk

Talquetamab plus Teclistamab in Relapsed or Refractory Multiple Myeloma

Clearance of Driver Mutations after Transplantation for Myelofibrosis

A Comparison of Peripherally Inserted Central Catheter Materials

  Journal of  American Medical Association

Changes in Patient Care Experience After Private Equity Acquisition of US Hospitals

Oral Glucose-Lowering Agents vs Insulin for Gestational Diabetes

  Annals of Internal Medicine

Cardiovascular Safety and Fracture Prevention Effectiveness of Denosumab Versus Oral Bisphosphonates in Patients Receiving Dialysis

Assessing the Risk for Falls in Older Adults After Initiating Gabapentin Versus Duloxetine

 British Medical Journal

Time to nursing home admission and death in people with dementia

 Lancet

Induced pluripotent stem-cell-derived CD19-directed chimeric antigen receptor natural killer cells in B-cell lymphoma: a phase 1, first-in-human trial

 Cancer Journal for Clinicians

Breast cancer statistics 2024

  Journal of Clinical Oncology

Minimally Invasive Assessment of Peripheral Residual Disease During Maintenance or Observation in Transplant-Eligible Patients With Multiple Myeloma

  journal of Hepatology

Effect of pemvidutide, a GLP-1/glucagon dual receptor agonist, on MASLD: A randomized, double-blind, placebo-controlled study

Induction of steatosis in primary human hepatocytes recapitulates key pathophysiological aspects of metabolic dysfunction-associated steatotic liver disease

  Gastroenterology

Unveiling Cancer-Related Metaplastic Cells in Both Helicobacter pylori Infection and Autoimmune Gastritis

Clinical Gastroenterology

 Satisfaction With and Adherence to Off-Label Corticosteroids in Adolescents and Adults With Eosinophilic Esophagitis: Results of a Web-Based Survey in the United States

 Clinical Infectious Diseases

Epidemiology and Prognostic Factors Associated With Mold-Positive Blood Cultures: 10-Year Data From a French Prospective Surveillance Program (2012–2022) 

 Rheumatology 

Frequency of Spondyloarthritis Symptoms Among U.S. Patients with Inflammatory Bowel Disease: A Cross‐sectional Multi‐Center Study

  Circulation

Sickle Trait and Alpha Thalassemia Increase NOS-Dependent Vasodilation of Human Arteries Through Disruption of Endothelial Hemoglobin-eNOS Interactions

 Journals of the American College of Cardiology

Drug-Coated Balloon Angioplasty of the Side Branch During Provisional Stenting: The Multicenter Randomized DCB-BIF Trial

 JAMA Cardiology

Microaxial Flow Pump Hemodynamic and Metabolic Effects in Infarct-Related Cardiogenic ShockA Substudy of the DanGer Shock Randomized Clinical Trial

 Journal of Clinical Endocrinology & Metabolism

Regional Adiposity and Insulin Sensitivity—Interactions With Menopause and HIV in Middle-Aged Black African Women

 Diabetes care

Trends and Inequalities in Diabetes-Related Complications Among U.S. Adults, 2000–2020

 Neurology

Patient-Relevant Digital-Motor Outcomes for Clinical Trials in Hereditary Spastic Paraplegia Type 7: A Multicenter PROSPAX Study

Chest

A 1-Year Weight Management Program for Difficult-to-Treat Asthma With Obesity

The American Journal of Respiratory and Critical Care Medicine

Association of Dose of Inhaled Corticosteroids and Frequency of Adverse Events

Clinical Journal of American Society of Nephrology

 Impaired Incretin Homeostasis in Nondiabetic Moderate-to-Severe CKD

Kidney International reports

Outcome of Patients Transplanted for C3 Glomerulopathy and Primary Immune Complex-Mediated Membranoproliferative Glomerulonephritis

Happy New year to all the listeners.

Thank you for listening in 2024 and hope to see you here weekly in 2025.

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Final, 10-Year Outcomes with Nivolumab plus Ipilimumab in Advanced Melanoma

Asundexian versus Apixaban in Patients with Atrial Fibrillation

Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy

Adjuvant Pembrolizumab versus Observation in Muscle-Invasive Urothelial Carcinoma

 Journal of  American Medical Association

Transcriptomic Profiles in Nasal Epithelium and Asthma Endotypes in Youth

 Annals of Internal Medicine

Implementation of Billing for Patient Portal Messages as E-Visits in a Large Integrated Health System

 British Medical Journal

Comparative effectiveness and safety of single inhaler triple therapies for chronic obstructive pulmonary disease

  Lancet

Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies

Population-health impact of new drugs recommended by the National Institute for Health and Care Excellence in England during 2000–20: a retrospective analysis

  journal of Hepatology

Metabolic phenotyping of patients with advanced chronic liver disease for better characterization of cirrhosis regression

 Gastroenterology

Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets

 Clinical Infectious Diseases

Clinical characterisation and outcomes of human clade IIb mpox virus disease 

 Circulation

Multiplexed Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification

 Journals of the American College of Cardiology

Using Electrocardiogram to Assess Diastolic Function and Prognosis in Mitral Regurgitation

 AMA Cardiology

Artificial Intelligence–Enhanced Electrocardiography for Prediction of Incident Hypertension

 Journal of Clinical Endocrinology & Metabolism

Regional Adiposity and Insulin Sensitivity—Interactions With Menopause and HIV in Middle-Aged Black African Women

  Neurology

Patient-Relevant Digital-Motor Outcomes for Clinical Trials in Hereditary Spastic Paraplegia Type 7: A Multicenter PROSPAX Study

 Chest

Exacerbation History and Risk of Myocardial Infarction and Pulmonary Embolism in COPD

Differential Association of COPD Subtypes With Cardiovascular Events and COPD Exacerbations

 The American Journal of Respiratory and Critical Care Medicine

Pyrazinamide Safety, Efficacy, and Dosing for Treating Drug-Susceptible Pulmonary Tuberculosis: A Phase 3, Randomized Controlled Clinical Trial

  Clinical Journal of American Society of Nephrology

Benefits and Harms of Coronary Revascularization in Non–Dialysis-Dependent Chronic Kidney Disease and Ischemic Heart Disease: A Systematic Review and Meta-Analysis

  Kidney International reports

Projecting the Population Level Burden of CKD Progression According to Urine Albumin-to-Creatinine Ratio Categories

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Ponsegromab for the Treatment of Cancer Cachexia

 Levofloxacin for the Prevention of Multidrug-Resistant Tuberculosis in Vietnam

 Ebola Outbreak Response in the DRC with rVSV-ZEBOV-GP Ring Vaccination

 Twice-Yearly Depemokimab in Severe Asthma with an Eosinophilic Phenotype

Journal of  American Medical Association

2024 Update of the RECOVER-Adult Long COVID Research Index

 Annals of Internal Medicine

iImpaired Wnt/Planar Cell Polarity Signaling in Yellow Nail Syndrome

  British Medical Journal

Christmas 2024: Age against the machine—susceptibility of large language models to cognitive impairment

 Lancet

Global, regional, and national progress towards the 2030 global nutrition targets and forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2021

  Journal of Clinical Oncology

Bladder-Preserving Trimodality Treatment for High-Grade T1 Bladder Cancer: Results From Phase II Protocol NRG Oncology/RTOG 0926

  journal of Hepatology

Type-I interferon shapes peritoneal immunity in cirrhosis and drives caspase-5-mediated progranulin release upon infection

  Gastroenterology

Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases

 Clinical Infectious Diseases

Impact of Intrapartum Azithromycin on the Carriage and Antibiotic Resistance of Escherichia coli and Klebsiella pneumoniae in Mothers and Their Newborns

  Rheumatology 

Achieving Medication‐Free Remission in Patients With Juvenile Dermatomyositis

  Circulation

Therapeutic Effects of Heart Failure Medical Therapies on Standardized Kidney Outcomes: Comprehensive Individual Participant–Level Analysis of 6 Randomized Clinical Trials

  Journals of the American College of Cardiology

Hypertensive Disorders of Pregnancy Increase the Risk for Myocardial Infarction: A Population-Based Study

  Diabetes care

Risk of Infection in Older Adults With Type 2 Diabetes With Relaxed Glycemic Control

 Chest

Occupational Exposure to Charcoal Smoke and Dust, a Major Risk Factor for COPD

Dexmedetomidine for Reducing Mortality in Patients With Septic Shock

The American Journal of Respiratory and Critical Care Medicine

Concordance and Prognostic Relevance of Different Definitions of Systemic Sclerosis Interstitial Lung Disease Progression

 Clinical Journal of American Society of Nephrology

Impairment of Cardiovascular Functional Capacity in Mild-to-Moderate Kidney Dysfunction

Kidney International reports

Projecting the Population Level Burden of CKD Progression According to Urine Albumin-to-Creatinine Ratio Categories