After draining his life savings to enter a team in the Rucker Classic streetball tournament in Harlem, Dax (Lil Rel Howery) is dealt a series of unfortunate setbacks, including losing his team to his longtime rival (Nick Kroll). Desperate to win the tournament and the cash prize and impress his girlfriend (Tiffany Haddish), Dax stumbles upon the man, the myth, the legend Uncle Drew (Kyrie Irving) and convinces him to return to the court one more time. The two men embark on a road trip to round up Drew's old basketball squad comprised of actual NBA stars (Shaquille O'Neal, Chris Webber, Reggie Miller, Nate Robinson, and Lisa Leslie) and prove that a group of septuagenarians can still win the big one.