This week, 124 countries agreed at the World Health Assembly in Geneva on measures aimed at preventing a future pandemic. The agreement very strongly favours a “One Health” approach, appreciating how so many potential pathogens originate in human-animal interactions. Still to agree on the terms of how to share pathogens and information with global science and vaccine researchers, eventually the treaty will need to be signed by at least 60 countries. But can the inequity between countries of the global south and north, and issues of intellectual property, be bridged?

A new study on origins of the Nigerian mpox epidemic points strongly to zoonotic crossovers and mobility of wildlife in West Africa. Edyth Parker of Redeemer’s University in Nigeria describes their phylogenetic tree.

Can the bovine form of H5N1 flu infect pigs, and could domestic pig populations then provide a crucible for further variants to develop? Jürgen Richt of Kansas State University and colleagues have been investigating. We need to keep up vigilance.

Lucy van Dorp of University College London, working with a consortium including London’s Crick Institute, has been looking at a moment in the past when human activity provided an opportunity for a bacterial human pathogen to change its lifestyle. According to their phylogenetic tree, the bacterium Borrelia recurrentis (which causes louse-borne relapsing fever in humans) adapted and moved from ticks to human body lice around about the same time as humans started using woollen clothing.

And Susan Lieberman, VP for International Policy at the Wildlife Conservation Society, was in the trenches of the Pandemic Agreement negotiations, and shares some of her hopes for its success.

Image: World Health Assembly formally adopts by consensus world's first Pandemic Agreement, Geneva, Switzerland - 20 May 2025

Presenter: Roland Pease