President-elect Donald Trump has selected Dr. Marty Makary, surgeon and public policy researcher at Johns Hopkins University, as his nominee for FDA chair. Will revisits a conversation he had with him shortly before the election on what he would do to reform America's medical system, and how to attack the systemic challenges they face.

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Story #1: Will gives his top 5 tips to thrive on Thanksgiving, plus he breaks down if President-elect Trump can stop a potential World War 3.

Story #2: Will is joined by his FOX & Friends Weekend co-Host, Rachel Campos-Duffy, to discuss what Thanksgiving is like in the Duffy household and what life for the Duffys will be like now that her husband, Sean, has been nominated by President-elect Trump to become the next Secretary of Transportation. Plus, Rachel previews the new FOX Nation special directed by Martin Scorsese, The Saints.

Story #3: The crew breaks down how the 12 team College Football Playoff should shake out. Don't expect too many surprises. 

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Story #1: After all of the suggestions of self-reflection, what do the media and Democrats do after the election? Triple down! Elon Musk and X are facing criticism from a mainstream media who are losing control of the narrative. 

Story #2: What kind of cuts can we expect from Elon Musk, Vivek Ramaswamy, and DOGE? Plus, President-elect Donald Trump threatens Mexico, Canada, and China with tariffs. Breaking down what this means with economist, host of the ‘Peter St Onge, Ph.D Podcast’ & visiting fellow at the Heritage Foundation, Peter St Onge.

Story #3: According to the Author of ‘Sex and the Citizen: How the Assault on Marriage is Destroying Democracy,’ Conn Carroll, the data shows the Democrats might actually be the party of single cat ladies. 

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Story #1: Weekend Quick Hits: Should Elon buy MSNBC? What would that mean for the rest of the media? Mayor Glenn "Kane" Jacobs warns Dwayne "The Rock" Johnson to steer clear of politics. Plus, the importance of squirrel hunting.

Story #2: The movement to stop child trafficking makes its way to Time Square. From the big screen to the streets of New York to make sure the victims are being seen: A conversation with Former Wall Street Trader and Movie Financier, John Devaney.

Story #3: Now that former Congressman Matt Gaetz is out of the running for Attorney General, what does that mean for other picks like Tulsi Gabbard, Pete Hegseth, and RFK, Jr.? Plus, is Vice President Kamala Harris preparing another presidential run in 2028? Will sits down with Senior Advisor to President-elect Donald Trump & host of Here's The Deal on FOX Nation, Kellyanne Conway.

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On this edition of The Will Cain Show’s Friday sports episode, Will sits down with former NFL lineman, three-time Super Bowl champion, and Host of ‘Breakfast Ball’ on FS1 from 8-10a ET, Mark Schlereth. They discuss whether or not Eli Manning is a Hall of Famer, what is going on as the Dallas Cowboys face one of their worst seasons in years, and if the undefeated Indiana Football team is up to the task as they face their first major opponent on Saturday, Ohio State.

Plus, Will and Mark go head to head making picks in the big College and NFL games this weekend in "Will Versus The Experts."

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Story #1: MSNBC craters! Panic among the ranks! Joe Scarborough & Mika Brzezinski visit President-elect Donald Trump as other talent call agents asking about their futures as Comcast spins off MSNBC. Will breaks it all down with FOX News Contributor, Joe Concha.

Story #2: Will's Rabbit Hole: What the novel 'Demon Copperhead' can tell us about the story of America.  

Story #3: During the show, former Congressman Matt Gaetz (R-FL) withdrew his nomination for Attorney General. What's next for Gaetz and the remaining nominees? The Author of ‘The Rise Of Blue Anon: How The Democrats Became A Party Of Conspiracy Theorists,’ David Harsanyi, breaks it all down. Plus, he shares the Democrat's three wildest conspiracies.

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Story #1: Pete Hegseth nominated for Secretary of Defense. Rachel Campos Duffy's husband, former Congressman Sean Duffy, nominated for Secretary of Transportation. Will is the last man standing on FOX & Friends Weekend! Plus, Will shares about his experience on the 'PBD Podcast' and how a host of 'The View' was forced to issue a correction on her claims against Matt Gaetz.

Story #2: Are the nominations of Pete Hegseth as Secretary of Defense, Senator Marco Rubio as Secretary of State, and Congressman Michael Waltz as National Security Advisor a disaster for U.S. foreign policy? Why did libertarians break for Trump this time around? Will is joined by comedian and libertarian, Dave Smith.

Story #3: Will there be four, maybe five SEC teams in the College Football Playoff? Who gets left out? A conversation with The Crew. 

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Story #1: Seven straight audits failed at the Pentagon. Military recruiting down decade over decade. Bureaucracy stifling military innovation. Blackwater founder, Erik Prince, joins Will to discuss if the Department of Defense can be fixed.

Story #2: Proof of the Left's radical shift away from the center in America with the host of 'The Grift Report,' Hotep Jesus!

Story #3: What is the most iconic picture of all time? Does the "Fight! Fight!" picture of a defiant President-elect Donald Trump move to number one?

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Story #1: Something is happening. You can feel the shift from Dallas to the streets of New York, to the ringside of UFC at Madison Square Garden, to the football field. President-elect Donald Trump's YMCA dance is everywhere, and it is suddenly cool to like Trump.

Story #2: Democratic Hypocrisy! Bucks County, Pennsylvania says they will thwart the Pennsylvania Supreme Court to keep counting votes. Plus, the media attacks President-elect Trump's cabinet: A conversation with New York Post Columnist, Karol Markowicz. 

Story #3: President-elect Trump's pick for FCC commissioner is ready to take on Big Tech and censorship. Will is joined by Director of the Tech Policy Center at The Heritage Foundation, Kara Frederick to break it down. 

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On this episode of The Will Cain Show's sports edition, Will takes a break from a long few weeks in politics to discuss something many find even more controversial: who is going to be in the College Football playoffs? Will sits down with Host of ‘Andy & Ari On3’ and College Football writer, Andy Staples, to discuss the biases around the different programs and conferences and how they are viewed in the rankings.

Plus, another week of 'Will Versus The Experts' where both Will & Andy make predictions on the biggest games in College Football and the NFL this weekend.

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