After we discussed the .243 in a previous 10 Minute Talk, many of you requested a similar episode on the venerable 22-250 round. A popular varmint, coyote and even potential deer/antelope cartridge with an incredibly cool backstory, the 22-250 is still a popular cartridge to this day, and we owe it all to some wacky wildcatters in their basements for devising this little beast. Ryan Muckenhirn joins Mark and Jimmy to discuss the who, what, where, when, why of this lean, mean, varmint-huntin’ machine!