Just as tribes were getting a handle on the spread of COVID-19 infections, a new variant and uneven vaccination rates revived the virus and brought new threats. That’s one of the key issues tribes faced in 2021. Other important issues of the year include Debra Haaland’s first months in office as the Secretary of the Interior, Oklahoma’s first full year adjusting to the McGirt Supreme Court decision, and an unprecedented level of emergency federal aid for tribes. We’ll look back at 2021 from an Indigenous perspective.