Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice.

In this episode, epilepsy expert Depobam Samanta, MD, MS, FAAP, FAES, sat down to discuss a recently published guidance paper from members of the Pediatric Epilepsy Research Consortium that provides recommendations for neuromodulation approaches to treat Lennox-Gastaut syndrome (LGS). Samanta, medical director of the Arkansas Children's Comprehensive Epilepsy Program, gave a clinical overview of the paper, highlighting the various neuromodulatory devices and their use, and the ways to improve treatment selection and personalization. Additionally, he talked about some of the potential complications with these devices as well as initiation and titration strategies for easy initiation. Furthermore, he spoke about ways to take neuromodulation to the next level, giving insight on creative trial designs, overcoming sham-controlled studies, and the necessary research to expand these approaches. 

Episode Breakdown:

1:05 – Overview of the published guidance and reasons behind the paper 

5:15 – Patient selection for neuromodulation and tailoring treatments by patient and preference

8:25 – Overcoming complications with neuromodulation devices 

11:25 – Multidisciplinary team necessary for successful implementation of neuromodulation

13:15 – Neurology News Minute

15:15 – Initiation and titration strategies for vagus nerve stimulation, deep brain stimulation, and resective surgery

18:30 – Next steps in research and expanding neuromodulation for patients with LGS

21:10 – Finding creative trial designs to test neuromodulation devices, combination approaches

The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here:

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