Dr. Darsh Shah and Dr. Altamash Raja continue their conversation with Dr. Shawn Arent on hormone physiology and performance. They dive into female physiology and menstrual cycle myths, the overlooked role of thyroid and reverse T3, catecholamines and autonomic balance, and the future of performance enhancement with GLP-1s and muscle-preserving drugs. A practical, evidence-based look at optimizing health and performance!

TIMESTAMPS

00:00 Introduction to Medicine Redefined

00:37 Deep Dive into Hormone Physiology

00:54 Female Physiology and Menstrual Cycle

01:03 Thyroid Hormone Optimization

01:12 Catecholamines and Autonomic Balance

01:23 GLP-1 Agonists and Muscle Preservation

01:58 Guest Introduction: Dr. Shawn Arent

02:21 Discussion on Female Physiology

02:29 Menstrual Cycle and Training

07:28 Hormonal Influence on Injury

07:50 Autoregulation in Training

19:03 Thyroid Hormone and Metabolism

33:55 Catecholamines and Training Response

40:55 Sympathetic vs. Parasympathetic Dominance

45:30 Tracking Trends for Better Interventions

45:53 Wearables and Recovery in Rugby

46:55 Debunking Post-Workout Downregulation

50:52 Contextualizing Fitness Advice

57:06 Balancing Training Methods

01:04:30 The Role of IGF-1 in Recovery

01:07:02 GLP-1 Agonists and Muscle Preservation

01:15:22 Myostatin Inhibitors: The Future of Muscle Growth?

01:21:25 Final Thoughts on Health and Performance

The Impact of Menstrual Cycle Phase on Athletes’ Performance: A Narrative Review MDPI

Current evidence shows no influence of women’s menstrual cycle phase on acute strength performance or adaptations to resistance exercise training Frontiers

The Effects of Menstrual Cycle Phase on Exercise Performance in Eumenorrheic Women: A Systematic Review and Meta-Analysis Springer

Influence of Menstrual Cycle Phases on Maximal Strength, Power and High-Intensity Interval Performance – A Systematic Review with Meta-Analysis MDPI

Evidence-Based Training Guidelines for Elite Women Football and Team Sports Human Kinetics

Hormones, Hypertrophy, and Hype: An Evidence-Guided Primer on Endogenous Endocrine Influences on Exercise-Induced Muscle Hypertrophy ESSR

Menstrual Cycle Effects on Sports Performance and Adaptations to Training: A Historical Perspective PubMed

Effect of Estrogen on Musculoskeletal Performance and Injury Risk Frontiers

Anterior Cruciate Ligament Injuries in Female Athletes: A Narrative Review of Prevention, Risk Factors, and Management Bone Jt Open

The Influence of Age on the Effectiveness of Neuromuscular Training to Reduce ACL Injury in Female Athletes: A Meta-Analysis PMC

Catecholamine and Cardiovascular Responses to Exercise: An Update Springer

Effects of Different Training Interventions on Heart Rate Variability in People with Overweight and Obesity: A Systematic Review Frontiers

Blood-Based Biomarkers for Monitoring Workload and Recovery in Athletes Sports Med Open

Changes in Lean Body Mass with the Use of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss and Strategies to Mitigate LBM Loss Wiley

ADA Newsroom: GLP-1 Agonists and Lean Body Mass ADA News

Effects of Subjective and Objective Autoregulation Methods in Resistance Training: A Systematic Review PeerJ

Biomarkers in Sports and Exercise: Tracking Health, Performance, and Recovery in Athletes Springer

Exercise, Training, and the HPT/HPA/HPG Axes in Athletes CSMR

Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance PMC

Optimizing Health and Athletic Performance for Women Springer

Thank you for listening!