Dr. Lisa Monteggia, a neuroscientist and Professor of Pharmacology at Vanderbilt University, shares her groundbreaking research on the antidepressant effects of ketamine. In this episode, we discuss how ketamine affects the brain—she reveals the neural mechanisms it induces in the brain, how it works differently than other antidepressant medicines (like SSRIs), and why dosing is so critical. We discuss Ketamine’s ability to induce plasticity in the brain and how that could revolutionize treatment for refractory depression.