More at http://philosophytalk.org/shows/finding-meaning-material-world.

All there is in the world is physical stuff. That is the fundamental assumption of the materialist standpoint, and the picture given to us by science. But if there is no immaterial soul that survives the death of the body, no other realm to bestow meaning on our lives, how can we avoid despairing in light of this apparent pointlessness? Is there any way we can build meaning from the naturalistic building blocks that science provides? John and Ken talk materially with Owen Flanagan from Duke University, author of "The Really Hard Problem: Meaning in a Material World."