In this episode, Prof Chapman unpacks the science behind endometrial receptivity—how the uterine lining changes after ovulation, what the “window of implantation” really means, and why timing is only one piece of the puzzle. He explains how tests like the ERA work, why a large trial found no improvement in pregnancy rates despite the cost, and why results can vary from one cycle to the next. Prof Chapman also weighs in on newer microbiome-based tests, and shares practical perspective on progesterone support and the risk of over-treatment in IVF and frozen embryo transfer cycles.

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