In this episode, Prof Chapman explains what poor fertilisation means in IVF and why it happens, despite everything appearing “normal.” He walks through expected fertilisation rates, how labs rule out technical issues, and why egg quality, age, sperm health, and DNA fragmentation are the most common underlying factors. Prof Chapman also outlines practical adjustments for future cycles, including the role of ICSI, timing changes, and realistic expectations after a disappointing fertilisation result.

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In this episode, Prof Chapman explains why there is currently no proven treatment that can reliably increase egg numbers or embryo yield in an IVF cycle, despite bold claims about supplements and therapies. He unpacks the limits of current science, addresses popular compounds like NMN, and emphasizes why lifestyle factors, realistic expectations, expert care, and emotional support matter far more than chasing unproven solutions. The discussion also explores what truly separates an excellent IVF clinic from a technically good one, personalized care, honest guidance, and support through repeated setbacks.

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Don’t miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman explains why a healthy diet and folic acid matter and why most advertised supplements don’t improve egg or sperm quality despite bold claims online. He also discusses when donor sperm or donor eggs become a practical next step in fertility treatment, outlining the medical realities, key decision points, and how specialists support patients through what can be an emotionally complex choice.

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Don’t miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman explains why extensive immune testing in IVF almost always finds something “abnormal” and why that doesn’t mean treatment will help. He breaks down the science behind immune markers, the lack of proven benefit from immune therapies, and how patients can be misled by results that sound concerning but change nothing clinically.

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Don’t miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman draws on nearly 40 years of IVF experience to unpack the growing use of so-called IVF “add-ons” or adjuvants. He explains why many treatments offered after failed cycles—such as CoQ10, DHEA, and testosterone—are not supported by strong scientific evidence, despite their popularity. Prof Chapman also clarifies real IVF success rates over multiple cycles, challenges misleading claims, and offers a grounded perspective on where hope truly comes from in fertility treatment.

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Don’t miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman explains when surgery for endometriosis can improve IVF success and when it may risk reducing ovarian reserve. He unpacks the differences between mild and severe disease, why embryos are often created and frozen before surgery, and how adenomyosis, fibroids, and polyps can affect implantation and miscarriage risk. Prof Chapman also addresses common myths around IVF medications and cancer risk, offering clear, evidence-based guidance to help patients make confident treatment decisions.

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Don’t miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman explains how IVF protocols are adjusted for women with PCOS, why PCOS patients often respond well to IVF, and how modern stimulation and antagonist protocols have significantly reduced the risks of OHSS. He also discusses when it’s worth optimizing health before treatment, why many women with PCOS may not need IVF at all, and what makes embryo transfers slightly more complex in this group—offering reassurance and clarity for patients navigating their options.

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Don’t miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman explains how advances in embryo freezing—particularly vitrification—have transformed IVF outcomes, making frozen embryo transfers just as successful as fresh transfers in many cases. He walks through the pros and cons of fresh versus frozen cycles, the original and current reasons for “freeze-all” strategies, and why factors like hormone levels, uterine environment, OHSS risk, and genetic testing all play a role in deciding the best approach. A clear, reassuring conversation to help patients understand why freezing embryos is often recommended and how the decision should be personalised.

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Don’t miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman explains why implantation failure can happen even in “healthy” patients—starting with the reality that it’s common in nature too. He shares that embryo genetics are a major cause, why PGT can improve success per transfer, and what doctors check next in repeat failures (uterine shape issues, chronic endometritis, key blood tests, and certain medical conditions). He also touches on the limits of immune-based treatments and ends with an encouraging reminder that success rates improve over multiple transfers.

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Don’t miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

In this episode, Prof Chapman unpacks the science behind endometrial receptivity—how the uterine lining changes after ovulation, what the “window of implantation” really means, and why timing is only one piece of the puzzle. He explains how tests like the ERA work, why a large trial found no improvement in pregnancy rates despite the cost, and why results can vary from one cycle to the next. Prof Chapman also weighs in on newer microbiome-based tests, and shares practical perspective on progesterone support and the risk of over-treatment in IVF and frozen embryo transfer cycles.

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Don’t miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.