In this episode, Prof Chapman explains what poor fertilisation means in IVF and why it happens, despite everything appearing “normal.” He walks through expected fertilisation rates, how labs rule out technical issues, and why egg quality, age, sperm health, and DNA fragmentation are the most common underlying factors. Prof Chapman also outlines practical adjustments for future cycles, including the role of ICSI, timing changes, and realistic expectations after a disappointing fertilisation result.

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