In this episode, Prof Chapman answers two important IVF questions: whether an Ovidrel trigger can cause a rise in TSH, and why the same patient can have very different ovarian responses in back-to-back IVF cycles. He explains the biology behind temporary thyroid changes during treatment, the role of rising estrogen, and why ovarian response is never exactly the same from one cycle to the next. Prof Chapman also explores the concept of follicle “waves,” how random-start IVF works, and what doctors consider when deciding the next protocol after an unexpectedly different cycle.

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