In this episode, Prof Chapman unpacks what specialists actually mean when they talk about egg quality. He explains that quality comes down to an egg’s competency to fertilise and produce an embryo with the right number of chromosomes, and why that process becomes less reliable as women age. He describes the tiny energy-producing structures called mitochondria, the batteries inside every egg, and how their decline disrupts the delicate work of lining up chromosomes at the right moment. He also walks through the spindle, the internal structure his own team studies using polarised light at Life Fertility, and how checking it before fertilisation helps predict whether a pregnancy is likely. It is an honest, reassuring look at the uphill odds women over 40 face, why most early miscarriages trace back to the egg rather than the parents, and what the science can and cannot tell us.

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