In this episode we will be talking to Luca Quartuccio, a rheumatologist and a renowned expert in cryoglobulinemia. You will hear about how we diagnose cryoglobulinemic vasculitis, whether we can have cryoglobulinemia without vasculitis, the types of cryoglobulinemia and their clinical significance, how to tackle secondary cryoglobulinemia with hepatitis C or B, first line therapy, the role of plasma exchange and maintenance therapy and much, much more. Dedicated to everybody who takes care of these difficult patients.