Freely Filtered, a NephJC Podcast

By NephJC Team

What's Freely Filtered, a NephJC Podcast about?

Twice monthly (aspirational) recap of the NephJC journal club. NephJC reviews the most important manuscripts which are driving nephrology forward and improving our understanding of the kidney.

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Freely Filtered, a NephJC Podcast episodes:

04.22.2024
Episode 69:DUPLEX Sparsentan, it’s no Acthar Gel
FSGS is hard and the data sucks. But here comes sparsentan fresh off its win in the PROTECT trial for IgA Nephropathy. Can it pull another rabbit out of the hat for patients that suffer from FSGS or are we...
03.16.2024
Freely Filtered 68: Inpatient hypertension
Beep Beep. Hey intern the patient’s blood pressure is 160/95. Do you want to do something. No. The answer is no. But honestly we have all been guilted into ordering some clonidine or god forbid some IV hydralazine. Stop it. Just stop it. Join...
03.07.2024
Freely Filtered 67: NephMadness and Animal House
NephMadness prides itself on not repeating topics. Most topics don’t get revisited for years after a single appearance. But one region stands alone. One region is making its fourth appearance in the 12 year history of NephMadness! That region is...
02.28.2024
Freely Filtered 66: NephJC Summer Book Club
So this one has been on the hard drive gathering dust for quite awhile. There were significant technical problems (in other words, Joel screwed up. But the episode is now complete and despite some obvious stutters, it turned out pretty...
02.10.2024
Freely Filtered 065: BEST Fluids
The fluids wars have been going back and forth and now have another big win. This time in transplant.
11.12.2023
Freely Filtered 064: Freely Filtered with The Curbsiders Live at Kidney Week!
On Friday of #KidneyWk, at the City Winery in Philadelphia, The Filtrate collaborated with The Curbsiders to do a live show in front of dozens of fans. Freely Filtered is proud to get to play a role in one of these...
11.03.2023
Freely Filtered 063: Late Breaking and High Impact Clinical Trial Simultaneous Release!
We love Kidney Week and the quintessential event at Kidney Week is the Late Break and High Impact Clinical Trial Sessions. Here we see the cutting edge of science revealed. We get to be first when years of work are...
09.25.2023
Freely Filtered 062: Inaxaplin for APOL1 Kidney Disease
Inaxaplin is a small molecule that is in trials for APOL1 associated kidney disease. Genome guided medicine comes to nephrology.
09.24.2023
Freely Filtered 061: Bicarb in Transplant
Bicarbonate did not slow the loss of GFR in this well done Swiss, single-blind study of transplant patients.The Filtrate:Joel TopfNayan AroraSwapnil HiremathPirya YenebereWith Special Guest:Nav Tangri nephrologist and epidemiology at the University of ManitobaEditor:Nayan AroraShow Notes:Arsenal FCThe London study that...
07.03.2023
Freely Filtered 059: Furosemide v Torsemide
Another dogma shredding trial about diuretics, this time torsemide goes up against king furosemide and its ability to prevent rehospitalization and CV events.
06.25.2023
Freely Filtered 060: HCTZ v Kidney Stones, The NOSTONE trial
Another dogma shredding trial about diuretics, this time hydrochlorothiazide ability to reduce symptomatic kidney stone events and kidney stone growth gets put under the knife.
05.02.2023
Freely Filtered 058: HCTZ v Chlorthalidone, The Diuretic Comparison Project
The diuretic comparison project is a large, well done, pragmatic trial, that puts to rest the debate of HCTZ versus chlorthalidone. Listen to the Filtrate wrestle with their own cognitive dissonance.
03.11.2023
Freely Filtered 057: NephMadness 2023 TMA
Welcome to the NephMadness PodCrawl The idea behind a podcrawl is for a variety of podcasts to coordinate on timing and topic to push a theme and get each other’s listeners to explore all of the podcasts. One of the first goals...
03.01.2023
Say "Hi" to the #NephMadness PodCrawl
Welcome to the NephMadness PodCrawlThe idea behind a podcrawl is for a variety of podcasts to coordinate on timing and topic to push a theme and get each other’s listeners to explore all of the podcasts. One of the first goals...
02.07.2023
Freely Filtered 056: MyTEMP
MYTEMP is the largest dialysis trial. 15000 patients, 4.3 million dialysis treatments. We bring in lead PI Amit Garg to help break it down the trial and its implications.
01.29.2023
Freely Filtered 055: STOP ACE!
For years there has been a growing dogma that if you stop the Renin Angiotensin inhibition when the GFR gets low you can delay dialysis. STOP ACE put the dogma to the test. The results are...meh.
12.25.2022
Freely Filtered 054: EMPA Kidney!
EMPA-Kidney is the last of the big three to report their Kidney Endpoints SGLT2i trial (CREDENCE for Cana, DAPA-CKD for Dapa, and now EMPA-Kidney for Empa) and it answers some questions that, amazingly, were still unanswered.
12.11.2022
Freely Filtered 053: The Kidney Week Draft
After a 2 year hiatus, Kidney Week returned with a great meeting, even if it was in Orlando. Relive some of the highlights with the Filtrate.
11.26.2022
Freely Filtered 052: Acetazolamide for Acute Decompensated Heart Failure (ADVOR)
Freely Filtered 051: ADVOR turns the practice of sequential nephron blockade on its head by blocking the proximal tubule before the loop of Henle. Does it work? Join The Filtrate as we dissect the latest diuretic RCT.
10.17.2022
Freely Filtered 051: Pip Tazo and Vanco: Nephrotoxin or Not so toxic
The Filtrate looks at a trial that tries to dissect the bumps in creatinine we regularly see with Pip/Tazo. Is it AKI or pseudonephrotoxicity?
10.08.2022
Freely Filtered 050: CLASSIC Trial
The Filtrate look at the latest contribution to Fluid Wars, this one looking at late resuscitation.
09.13.2022
Freely Filtered 049: Getting Salty with SODIUM-HF
SODIUM-HF is the largest and longest RCT done looking at sodium restriction heart failure. The top line results show no effect but the more you look at the study the more problematic it is. The Filtrate take it to task.
08.01.2022
Freely Filtered 048: Putting TESTING to the Test
TESTING is the latest IgA nephropathy trial and it is the comeback kid of nephrology trials. From a trial that was halted because of excess adverse events to a safe and effective therapy with just a few tweeks. Amazing turn...
06.29.2022
Freely Filtered 047: CHAP, time to treat hypertension in pregnancy
The Filtrate:Joel TopfNayan AroraSophia AmbrusoSwapnil HiremathJosh WaitzmanSpecial Guest:Natalie Bello Director of Hypertension Research at Cedars SinaiEditor:Nayan AroraShow Notes:NephJC summary of CHAPCHiPS TV showCHIPS study: Less-Tight versus Tight Control of Hypertension in PregnancyPrevention, Diagnosis, and Management of Hypertensive Disorders of Pregnancy:...
05.14.2022
Freely Filtered 046: The ISPD Peritonitis Guideline Draft
The Guideline Draft is back! This time the 2022 ISPD Peritonitis Guidelines are on the clock! The Filtrate are joined by PD junky Jade Teakall and guideline author, Jeff Perl.
05.09.2022
Freely Filtered 045: Salt Substitution and Stroke Study (SSaSS)
The SSaSS study is a landmark study in the study of sodium and its effect on blood pressure and mortality. Join the Filtrate as they do a deep dive.
04.11.2022
Freely Filtered 044: Pigs on the Wing: Xenotransplantation
The University of Alabama with Revicor have made a better pig. Better for transplanting. And they transplanted a pair of these into a brain dead patient. The filtrate discuss the case report with transplant surgeon, Josh Mezrich.
03.19.2022
Freely Filtered 043: NephMadness and Animal House
Freely Filtered is excited to be the final PodCast of the first NephMadness PodCrawl and we are covering the best region of NephMadness, Animal House!
02.27.2022
Freely Filtered 042: Nephrin Antibodies Cause Minimal Change Disease. Wait...What?
Minimal change disease has classically been described as having negative immunofluorescence and to not be antibody mediated. But here comes Dr Weins with a fresh study smashing this orthodoxy. She proposes anti-nephrin antibodies as the etiologic agent driving minimal change...
02.21.2022
Freely Filtered 041: Top Nephrology Stories of 2021
The Filtrate:Joel TopfSwapnil HiremathMatt SparksEditor:Joel TopfShow Notes:The 2010 RFN Top Nephrology StoriesThe 2021 NephJC Top Nephrology StoriesNumber 10: AKIKI AKIKI 2 in The LancetAKIKI 2 in NephJC AKIKI 2 on Freely FilteredNumber 9: Effect of Salt Substitution on Cardiovascular Events...
12.25.2021
Freely Filtered 040: Double CLICK for BP control in CKD stage 4
The Filtrate:Joel TopfSwapnil HiremathJennie Lin (who was only there because her plans got boxed by covid)Jordy CohenJosh WaitzmanSpecial Guest:Rajiv Agarwal (@AgarwalRajivMD)Editor:Joel TopfShow Notes:NephJC discussion of CLICK: http://www.nephjc.com/news/click4chlorthalidone CLICK Visual abstract: http://www.nephjc.com/news/2021/12/7/the-click-visual-abstract Hawthorne effect: https://en.wikipedia.org/wiki/Hawthorne_effect A nice discussion run in periods...
11.21.2021
Freely Filtered 039: The First Annual ASN #KidneyWk Draft
The Filtrate:Joel TopfSwapnil HiremathNayan AroraJennie LinSophie AmbrusoEditorJoel TopfShow Notes:Sign Up for NephSim Nephrons. Deadline 11/30. https://nephsim.com/nephsim-nephrons/ The Draft Board except for Swapnil’s picks because…Calvin Ball: https://docs.google.com/document/d/1Unk_27uqTpMGXrOyrxbI-2csKg2W_qnbbN7IE3wZY_Y/edit?usp=sharing Calvinball per the Calvin and Hobbes Wiki: Calvinball is a game invented by Calvin...
10.23.2021
Freely Filtered 038: AURORA1, a new treatment for Lupus Nephritis
Voclosporin is a new calcineurin inhibitors with reliable pharmacokinetics, i.e. no more therapeutic drug monitoring, and it was able to improve complete renal remission in lupus nephritis. But all that glitters is not gold. Join us as we dig deep...
07.25.2021
Freely Filtered 037: The first Guideline Draft: KDIGO Hypertension Guidelines
The KDIGO 2021 Hypertension Guidelines. We mixed things up and went with a Fantasy Football-style draft. Pick your favorite guideline, and remember not to take a kicker or a defense until the last rounds.
06.13.2021
Freely Filtered 036: AKIKI-2, How soon is now?
Nephrology has been the recent beneficiary of a handful of studies examining the impact of the timing of the initiation of dialysis in AKI. One of these trials, AKIKI, now has a genuine sequel. In 2016 AKIKI was the first...
05.25.2021
Freely Filtered 035: ASN Fellow Survey, COVID-19 Edition
Episode 035: The COVID-19 Pandemic changed everything and last fall the ASN set out to document how it affected our nephrology fellows. The ASN Workforce Committee adapted the Annual Fellow Survey to assess how the pandemic affected nephrology fellows in...
05.06.2021
Freely Filtered 034: Terlipressin for Hepatorenal Syndrome
Episode 034: A newly expanded filtrate assembled to discuss the tricky CONFIRM Trial recently published in the NEJM. We are assisted by Elliot Tapper, noted hematologist and member of #LiverTwitter.
04.20.2021
Freely Filtered 033: The Roxadustat Statistics shenanigans
On April 6, 2021 Fibrogen announced that the analysis of the cardiovascular outcomes was adjusted after the data was unblinded. When the data was reanalyzed without this adjustment roxadustat is less impactful. Importantly for this NephJC discussion, the previously impressive...
04.10.2021
Freely Filtered 032: Animal House
Animal House was one of the most exciting regions of NephMadness. We explore this region with the Selection Committee Member as well as the author to unlock the secrets of Animal House.
03.28.2021
Freely Filtered 031: Roxadustat
Roxadustat is the first HIF stabilizer up for FDA approval. There have been a number of roxa publications and today we took at the two most recent. One is a pooled analysis of incident dialysis patients: roxa versus epoetin alpha....
03.15.2021
Freely Filtered 030: DAPA-CKD
The DAPA program busted SGLT2i out of the diabetes paradigm by showing that dapagliflozen improved heart failure and CKD outcomes in a patients with or without diabetes.
02.15.2021
Freely Filtered 029: Belimumab for lupus nephritis
The Filtrate welcome Dawn Caster and Alfred Kim to discuss lupus nephritis, B-cell biology and a new option for LN, belimumab.
12.25.2020
Freely Filtered 028: Finerenone for diabetic kidney disease
The Filtrate welcome Anna Burgner and hypertension legend George Bakris to discuss the opera and RCT, Fidelio.
11.29.2020
Freely Filtered 027: Long and deep on the KDIGO Diabetes Guidelines
The filtrate welcome Drs. Katherine Tuttle and Ian de Boer to discuss the first KDIGO diabetic kidney disease guideline.
11.06.2020
Freely Filtered 026: Interventional Nephrology meet NephJC, NephJC meet Interventional Nephrology
The filtrate welcome Drs. Vandana Dua Niyyar and Sophia Ambruso to discuss the recent paper in the NEJM, "Drug-Coated Balloons for Dysfunctional Dialysis Arteriovenous Fistulas."
09.21.2020
Freely Filtered 025: Making sense of albuminuria, proteinuria, and the dipstick
The filtrate welcome Drs. Morgan Grams and Talar Kharadjian to discuss the recent paper in Annals of Internal Medicine: Conversion of Urine Protein-Creatinine Ratio or Urine Dipstick Protein to Urine Albumin-Creatinine Ratio for Use in Chronic Kidney Disease Screening and...
09.01.2020
Freely Filtered 024: STARRT me up!
The Filtrate:Matt SparksJoel TopfSwapnil Hiremath COI: he was a sub-investigator on STARRTJennie LinAnd two special guests:Dr. Jay Koyner of the University of Chicago and #NephBBQ fame.Anitha Vijayan, professor of medicine at Wash U in St LouisShow Notes:The STARRT-AKI trial acronym...
08.20.2020
Freely Filtered 023: Race and Estimated GFR
The Filtrate:Matt SparksJoel TopfSwapnil HiremathSamira FaroukJennie LinAnd three special guests:Carina Seah a second year MD PhD student Mt Sinai who led the initiative to remove race from the eGFR formulasPoyan Mehr, founder of GlomCon and author of this post on...
07.28.2020
Freely Filtered 022: Uric Acid faces the Music.
The Freely Filtered team welcomes Katalin Susztak to talk about the recent pair of studies that examined the use of allopurinol to prevent the progression of CKD. It didn't work.
07.14.2020
Freely Filtered 021: Aldosteronism is everywhere
The Freely Filtered team welcome Susan Steigerwalt and Brian Byrd to talk about the recent study published in Annals of Internal Medicine that looks for hyperaldosteronism in patients with high salt intake and suppressed renin.

What's Freely Filtered, a NephJC Podcast about?

Download our free app to listen on your phone

Freely Filtered, a NephJC Podcast episodes:

Episode 69:DUPLEX Sparsentan, it’s no Acthar Gel

Freely Filtered 68: Inpatient hypertension

Freely Filtered 67: NephMadness and Animal House

Freely Filtered 66: NephJC Summer Book Club

Freely Filtered 065: BEST Fluids

Freely Filtered 064: Freely Filtered with The Curbsiders Live at Kidney Week!

Freely Filtered 063: Late Breaking and High Impact Clinical Trial Simultaneous Release!

Freely Filtered 062: Inaxaplin for APOL1 Kidney Disease

Freely Filtered 061: Bicarb in Transplant

Freely Filtered 059: Furosemide v Torsemide

Freely Filtered 060: HCTZ v Kidney Stones, The NOSTONE trial

Freely Filtered 058: HCTZ v Chlorthalidone, The Diuretic Comparison Project

Freely Filtered 057: NephMadness 2023 TMA

Say "Hi" to the #NephMadness PodCrawl

Freely Filtered 056: MyTEMP

Freely Filtered 055: STOP ACE!

Freely Filtered 054: EMPA Kidney!

Freely Filtered 053: The Kidney Week Draft

Freely Filtered 052: Acetazolamide for Acute Decompensated Heart Failure (ADVOR)

Freely Filtered 051: Pip Tazo and Vanco: Nephrotoxin or Not so toxic

Freely Filtered 050: CLASSIC Trial

Freely Filtered 049: Getting Salty with SODIUM-HF

Freely Filtered 048: Putting TESTING to the Test

Freely Filtered 047: CHAP, time to treat hypertension in pregnancy

Freely Filtered 046: The ISPD Peritonitis Guideline Draft

Freely Filtered 045: Salt Substitution and Stroke Study (SSaSS)

Freely Filtered 044: Pigs on the Wing: Xenotransplantation

Freely Filtered 043: NephMadness and Animal House

Freely Filtered 042: Nephrin Antibodies Cause Minimal Change Disease. Wait...What?

Freely Filtered 041: Top Nephrology Stories of 2021

Freely Filtered 040: Double CLICK for BP control in CKD stage 4

Freely Filtered 039: The First Annual ASN #KidneyWk Draft

Freely Filtered 038: AURORA1, a new treatment for Lupus Nephritis

Freely Filtered 037: The first Guideline Draft: KDIGO Hypertension Guidelines

Freely Filtered 036: AKIKI-2, How soon is now?

Freely Filtered 035: ASN Fellow Survey, COVID-19 Edition

Freely Filtered 034: Terlipressin for Hepatorenal Syndrome

Freely Filtered 033: The Roxadustat Statistics shenanigans

Freely Filtered 032: Animal House

Freely Filtered 031: Roxadustat

Freely Filtered 030: DAPA-CKD

Freely Filtered 029: Belimumab for lupus nephritis

Freely Filtered 028: Finerenone for diabetic kidney disease

Freely Filtered 027: Long and deep on the KDIGO Diabetes Guidelines

Freely Filtered 026: Interventional Nephrology meet NephJC, NephJC meet Interventional Nephrology

Freely Filtered 025: Making sense of albuminuria, proteinuria, and the dipstick

Freely Filtered 024: STARRT me up!

Freely Filtered 023: Race and Estimated GFR

Freely Filtered 022: Uric Acid faces the Music.

Freely Filtered 021: Aldosteronism is everywhere