Everything Hertz

79: Clinical trial reporting (with Henry Drysdale)

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We chat with Henry Drysdale (University of Oxford), co-founder of the COMPare trials project, which compared clinical trial registrations with reported outcomes in five top medical journals and qualitatively analysed the responses to critical correspondence.

Discussion points and links galore:

  • The history behind the COMPare project
  • The two papers that were published: a prospective cohort study correcting and monitoring 58 misreported trials and a qualitative analysis of researchers’ responses to critical correspondence
  • Ben Goldacre's books
  • What is outcome switching?
  • What were some of the responses to query letters from the authors and journals?
  • Misreporting trials (usually) doesn't lead to patient harm, but it harms the evidence base
  • Where should the buck stop with outcome switching?
  • Would Registered Reports solve this problem?
  • The CONSORT guidelines
  • Have the journals changed their practices?
  • COMPare on twitter
  • The COMPare website
  • Here is Henry on Twitter - @HenryMDrysdale
  • Here is Ben Goldacre on Twitter - @bengoldacre

    • Other links

    • [Dan on twitter](www.twitter.com/dsquintana)
    • [James on twitter](www.twitter.com/jamesheathers)
    • [Everything Hertz on twitter](www.twitter.com/hertzpodcast)
    • [Everything Hertz on Facebook](www.facebook.com/everythinghertzpodcast/)

      • Music credits: [Lee Rosevere](freemusicarchive.org/music/Lee_Rosevere/)

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        • Episode citation and permanent link

        Quintana, D.S., Heathers, J.A.J. (Hosts). (2019, March 4) "Clinical trial reporting (with Henry Drysdale)", Everything Hertz [Audio podcast], doi: 10.17605/OSF.IO/HBX8R

        Special Guest: Henry Drysdale.

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