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In this episode, Gunter Hoglinger, MD, professor of neurology and translational neuroscientist at Ludwig Maximillian's University Munich, provided commentary on a newly initiated phase 3 study assessing AMX0035 (Relyrvio; Amylyx Pharmaceuticals) in patients with progressive supranuclear palsy (PSP). Otherwise known as the ORION trial, Hoglinger discussed what went into trial inclusion, primary end points, and why they believe this therapy, which was approved for patients with amyotrophic lateral sclerosis (ALS) in 2022, could have benefits in PSP. 

Episode Breakdown:

1:15 – Underlying mechanisms of progressive supranuclear palsy

3:30 – Similarities and differences between ALS and PSP

5:00 – Overview of ORION study design

7:00 – Neurology News Minute

9:15 – Reasons behind specific trial inclusion

10:35 – Primary end points of the study 

12:50 – Significance of a potentially successful trial

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The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here:

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