Twenty years ago, scientists found that phenylephrine, listed as a decongestant in many cold medicines, didn’t work. What can you use instead?

A Common Cold Medicine Ingredient Doesn’t Work. What Now?

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DNA has long been studied and understood as the genetic blueprint for life on Earth. And related scientific endeavors, like the Human Genome Project, have received enormous attention. But DNA’s lesser-known counterpart, RNA, which translates the instructions from those blueprints into proteins in our cells, has received far less focus. But a lot’s changed in the last few years. The success of the mRNA COVID vaccines has led to a renewed interest in the potential medical therapies for this tiny molecular powerhouse, with applications ranging from CRISPR gene-editing to an mRNA-based cancer vaccine. Dr. Thomas Cech, distinguished professor in biochemistry at University of Colorado, Boulder, and the author of the book The Catalyst: RNA and the Quest to Unlock Life’s Deepest Secrets, joins Ira Flatow to tell us how why RNA has gotten the shorter end of the research stick for so long, how it could help us understand the origins of life, and why this misunderstood molecule might be the key to a next generation of big scientific discoveries. Read an excerpt from The Catalyst: RNA and the Quest to Unlock Life’s Deepest Secrets at sciencefriday.com. Transcripts for each segment will be available after the show airs on sciencefriday.com.  
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Step Aside, DNA. It’s RNA’s Time To Shine.

A Week Of Milestones For SpaceflightThis has been a week of milestones for human spaceflight. After years of delays, Boeing’s Starliner capsule, carrying astronauts Butch Wilmore and Suni Williams, successfully launched Wednesday on the United Launch Alliance’s Atlas V rocket. On Thursday, it docked with the International Space Station. Also on Thursday, SpaceX’s Starship rocket made its first successful launch and reentry after three previous attempts (the massive rocket burned up in the atmosphere on the last launch). And on a more sobering note, NASA announced that its famous 34-year-old Hubble Space Telescope is experiencing issues with its gyroscopes and is opting to only use one for the time being. The agency says Hubble can still do science, but less efficiently than it once could. Maggie Koerth, science writer and editorial lead for Carbon Plan, joins Ira to discuss those and other top stories in science this week, including why the viral Joro spider you may have seen online does not pose a threat to humans, how a virus that’s spreading due to deforestation in South America could overwhelm local healthcare, and why the FDA voted against the medical use of MDMA.Mexico Has Elected A Scientist President. What Will That Mean?This week, Mexico elected a historic president: Claudia Sheinbaum Pardo, who will be the first woman to lead the nation, and was also an environmental engineer before entering politics. Despite the president-elect’s scientific past, Sheinbaum Pardo has committed to following the lead of her predecessor, Andrés Manuel López Obrador, whose science policies were deeply unpopular with many researchers in the country. Mexico’s scientific community is split on how this election will impact science and research in the country. Rodrigo Pérez Ortega, a reporter at Science Magazine, joins Ira to talk through the complexities of this election and how scientists are reacting. Transcripts for each segment will be available after the show airs on sciencefriday.com.
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A Week Of Milestones For Spaceflight | Mexico Has Elected A Scientist President

Scientists are studying birds’ unique vocal organ, the syrinx, to better understand its evolutionary history. Also, the eerie calls of the common loon have been heard in songs by Michael Jackson, Lady Gaga, Lana Del Rey, and more.The Organ That Gives Birds Their VoicesHave you ever wondered how a bird sings? Or made some of their less melodic vocalizations, like squawks, trills, or chirps? It all happens in the syrinx, a vocal organ unique to birds. Reptiles, amphibians, and mammals, including humans, use their larynx to produce sounds. The syrinx varies widely between bird species and there’s still a lot that scientists don’t understand about how it works and its evolutionary history. Better understanding the syrinx of living birds can help scientists get closer to figuring out what dinosaurs sounded like. (No, the dinosaur sounds in “Jurassic Park” are not scientifically accurate.) Guest host Arielle Duhaime-Ross talks with Dr. Julia Clarke, professor of vertebrate paleontology at the Jackson School of Geosciences at the University of Texas, Austin, about her recent research studying the syrinxes of ostriches and hummingbirds.Common Loons Are Pop Music IconsFor decades now, one music star has managed to show up on tracks spanning multiple genres and appear alongside many famous artists—while also remaining bafflingly under-recognized. Any guesses? Of course, we’re talking about none other than the common loon—a waterbird with striking red eyes and black-and-white checkerboard plumage. This bird’s calls have been used in songs by artists like Michael Jackson, Nicki Minaj, Lady Gaga, Doja Cat, and Lana Del Rey. They’ve also been used as a sound effect in Hollywood blockbusters like “Harry Potter” and the TV show “Game of Thrones.” So how did this bird’s call become a regular in everything from hip hop and EDM to pop music? A story in Audubon Magazine dove into this, and guest host Arielle Duhaime-Ross talks with author Maddie Burakoff, an associate editor at Audubon. Transcripts for each segment will be available after the show airs on sciencefriday.com.
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The Organ That Gives Birds Their Voices | Common Loons Are Pop Music Icons

You might’ve heard this phrase before: data equals power. Because when you have data, you can decide how they’re used and who gets to use them. The history of research on Indigenous communities in the United States is full of stories of exploitation, power imbalances, and stolen knowledge. Be it through the iodine experiments of the 1950s in Alaska, the racist and pseudoscientific conclusions drawn by American anthropologists in the 20th century, or through more recent examples in which genetic data from communities were used in studies without their consent— these practices have caused lasting mistrust and harm. The growing field of Indigenous data sovereignty demands that Native communities maintain the right to decide how data about their people are collected, owned, and used. Guest host Arielle Duhaime-Ross talks with two people at the forefront of this movement: Dr. Stephanie Carroll is the director of the Collaboratory for Indigenous Data Governance and an associate professor of public health at the University of Arizona in Tucson. She is also Ahtna and a citizen of the Native Village of Kluti-Kaah in Alaska. Dr. Krystal Tsosie is a co-founder of the Native BioData Consortium and an assistant professor and geneticist-bioethicist at Arizona State University in Tempe. She’s a member of Navajo Nation. They discuss how data on Indigenous Peoples has been used and abused, why data sovereignty is more important than ever, and what solutions look like. Transcripts for each segment will be available after the show airs on sciencefriday.com.
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Indigenous Nations Are Fighting To Take Back Their Data

Are plants intelligent? Until recently, botanists were hesitant to ask that question, at least publicly. But that’s changing. In recent years researchers have learned more about how plants communicate with each other, respond to touch, store memories, and deceive animals for their own benefit: All bits of evidence that suggest plants possess a unique form of intelligence that humans have been overlooking. Guest host Arielle-Duhaime Ross talks with science journalist Zoë Schlanger about her new book, The Light Eaters: How The Unseen World Of Plant Intelligence Offers A New Understanding Of Life On Earth. Schlanger is currently a staff writer at the Atlantic covering climate change.
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A Common Cold Medicine Ingredient Doesn’t Work. What Now?

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