In 2022, the Nobel Prize in Chemistry went to Dr. Carolyn Bertozzi of Stanford University, Dr. Morten Meldal of the University of Copenhagen, and Dr. K. Barry Sharpless of the Scripps Research Institute “for the development of click chemistry and bioorthogonal chemistry.” In “click chemistry,” molecular building blocks snap together quickly and efficiently to let chemists build more complicated molecules. But bioorthogonal chemistry takes that work one step further, allowing the technique to be used within living organisms without damaging cells.

“When someone is thinking outside the box, or in a very different way, we like to think of that as orthogonal thinking,” Bertozzi explained. “So biorthogonal means not interacting with biology. Totally separate from biology.” Her research began with an interest in developing ways to see specific sugar molecules on the surface of cells. But it has developed into an approach that can be used for advanced drug delivery in fields such as chemotherapy.

As part of Science Friday’s 33rd anniversary show, we’re revisiting our listeners’ favorite stories, including this one. In 2022, Bertozzi joined Ira Flatow for a wide-ranging conversation about her research, chemistry education, her early music career, and the importance of diversity in the field of chemistry.

Transcripts for each segment will be available after the show airs on sciencefriday.com.

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