My guests, Audrey Stillerman, MD, and Bridget Gavaghan will discuss the Illinois ACEs Response Collaborative (the Collaborative) and the Center for Collaborative Study of Trauma, Health Equity, and Neurobiology (THEN). The organizations have been working for over a decade to transform organizations and systems through trauma-informed, resilience-building, and healing-centered policies and practices. A cross-sector movement to prevent trauma and promote thriving across the lifespan, the Collaborative places the impact of childhood experience on wellbeing at the forefront of the equity agenda in Illinois. It leads trainings, advocates for policy change, and translates research for the public, policymakers, and partner organizations. The Collaborative convenes a working group of Chicago hospital representatives championing trauma-informed transformation within their systems. In 2021, the Collaborative released an Action Plan to Address Childhood Adversity in Illinois ("Action Plan") developed through a multi-sector strategic planning process with leaders and community members across the state. The Collaborative is now leading efforts to implement the Action Plan. THEN is a virtual non-profit of clinicians, educators, researchers, and activists pursuing Health, Equity, and Justice for all. THEN works to transform health care and health professional training. THEN designs and delivers curricula that translate the science connecting life experiences and health into prevention and healing theory and practice, with a particular focus on individual patient care.