In this inaugural episode of ACM ByteCast, Rashmi Mohan is joined by 2017 ACM A.M. Turing Laureates John Hennessy and David Patterson. Their conversation touches on the paths that led these two luminaries to pursue computing careers and the "aha moment" that inspired their breakthrough work on RISC microprocessor architecture. They also discuss how they see the future of computing architecture unfolding in the coming years, the need for new memory technologies and better security, the importance of collaboration in innovation, and the promise of the open source community to develop both better software and hardware.