In this episode of TopMedTalk, hosted by Andy Cumpstey at the anaesthesia research meeting in Birmingham, we dive into drug allergy and its mislabeling with Louise Savic, consultant anaesthetist and NIHR doctoral researcher at Leeds Teaching Hospitals NHS Trust, UK, who specialises in drug allergy and peri-operative anaphylaxis, and Tom Abbott, clinical senior lecturer in anaesthesia and peri-operative medicine at Queen Mary University of London, UK, and a consultant anaesthetist whose research uses clinical epidemiology and trials to improve surgical outcomes and reduce peri-operative complications.

The discussion highlights the vast disparity between true drug allergies and mislabeling, emphasizing that around 90-95% of penicillin allergy labels are incorrect. Dr. Savic shares her journey in drug allergy research, focusing on the perioperative setting, while Dr. Abbott discusses the linkage between antimicrobial prescribing and resistance.

The talk covers results from the Sapphire Project, revealing the high incidence of mislabeled drug allergies and their associated increased postoperative risks. The episode also explores potential strategies for 'de-labeling' patients, the role of multidisciplinary collaboration, and the next steps in research and practice change.

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