March 09, 2026

Advancing KRAS G12C-Targeted Therapies in NSCLC: Current Evidence and Future Directions

16 minutes

In this episode, Dr Paz-Ares and Dr Christine Bestvina discuss the evolving role of KRAS G12C inhibitors in non-small-cell lung cancer (NSCLC), including:

Clinical outcomes and limitations of first-generation KRAS G12C inhibitors

Key unmet needs, including primary and acquired resistance

Emerging strategies, including next-generation inhibitors and combination approaches with chemotherapy and immunotherapy

Presenters:

Luis Paz-Ares, MD, PhD

Head of Medical Oncology Department

Hospital Universitario 12 de Octubre

Associate Professor, Universidad Complutense de Madrid

Madrid, Spain

Christine Bestvina, MD

Associate Professor

University of Chicago Medicine

Division of Medicine

Section of Hematology/Oncology

University of Chicago Medicine

Chicago, Illinois

Link to full program:
https://bit.ly/4rhoUuN

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By Decera Clinical Education

4.9

1010 ratings

March 09, 2026

Advancing KRAS G12C-Targeted Therapies in NSCLC: Current Evidence and Future Directions

16 minutes

In this episode, Dr Paz-Ares and Dr Christine Bestvina discuss the evolving role of KRAS G12C inhibitors in non-small-cell lung cancer (NSCLC), including:

Clinical outcomes and limitations of first-generation KRAS G12C inhibitors

Key unmet needs, including primary and acquired resistance

Emerging strategies, including next-generation inhibitors and combination approaches with chemotherapy and immunotherapy

Presenters:

Luis Paz-Ares, MD, PhD

Head of Medical Oncology Department

Hospital Universitario 12 de Octubre

Associate Professor, Universidad Complutense de Madrid

Madrid, Spain

Christine Bestvina, MD

Associate Professor

University of Chicago Medicine