Catherine Berry, ACTnet Steering Committee member and ID physician at John Hunter Hospital, Newcastle, was joined by Dr Jodie Schildkraut and Dr Van Le Hong, key researchers in the global Unite4TB consortium, which is accelerating the development of new TB treatments.

Dr Schildkraut, based at Radboud University Medical Center, leads the Phase 2B/C clinical trials work package and coordinates across multiple TB consortia. Dr Van Le Hong, a pulmonologist and clinical research fellow at OUCRU Vietnam, heads the multi-arm, multi-stage (MAMS) trial platform in Ho Chi Minh City.

Together, they explore Unite4TB’s approach to transforming TB regimen development, strengthening trial platforms, advancing biomarkers, improving early-phase design, and harmonising global research efforts, while reflecting on the practical challenges of conducting trials in high-burden settings.