
Sign up to save your podcasts
Or


Alzheimer’s disease ended his career as a physician and threw his life into chaos, but Dr. Brent Beasley says he feels hopeful. In fact, he said the new anti-amyloid therapies available for patients like himself have made him an “Alzheimer’s survivor.” In this episode, Dr. Jason Karlawish sits with Dr. Beasley to hear his story, how his community has continued to sustain him, and why there’s reason to be hopeful about an Alzheimer’s diagnosis in 2026.
Inside this episode:
3:11 – Living Truthfully with Alzheimer’s: Dr. Beasley explains why he immediately shared his diagnosis with his church community and how openness helped him find support.
8:56 – The Power of a Biomarker Diagnosis: Dr. Beasley discusses receiving a p-tau217 blood test result that confirmed Alzheimer’s disease and how diagnostic certainty changed his outlook.
14:26 – The Stigma of “Dementia:” Dr. Karlawish and Dr. Beasley explore the stigma surrounding dementia and the consequences of using the term as a political insult.
16:45 – Purpose, Joy, and Grandchildren: Dr. Beasley describes the people, relationships, and activities that give his life meaning, from music and writing to his growing family.
18:16 – The Care Partner Behind the Care: Dr. Beasley shares how his wife Cindy navigated insurance hurdles, treatment approvals, and the complex healthcare system to help him access lecanemab.
32:31 – The Four-Letter Word: Dr. Beasley closes his conversation with a single message for listeners: hope.
34:52 – Why Community Matters: Dr. Karlawish reflects on the role of friends, family, faith communities, and care partners in helping people live well with cognitive impairment.
39:40 – Living With Alzheimer’s in the Era of Treatment: Dr. Karlawish and Terrence Casey discuss how Dr. Beasley’s experience differs from previous generations and what anti-amyloid therapies can and cannot do.
44:49 – The Hope Future Treatments: A discussion of anti-tau therapies, emerging research, and why cautious optimism is appropriate for the field today.
Resources available on the episode webpage linked below
Special thanks this episode to Brent Beasley, MD, for sharing his story and today’s co-hosts, Jason Karlawish, MD, and Terrence Casey.
The Age of Aging is a Penn Memory Center production hosted by Terrence Casey and Executive Producer Jason Karlawish. Contributors include Morgann Adams, Dalia Elsaid, Holly Elser, Jake Johnson, Emily Largent, and Alison Lynn.
The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub Fund, Lena Chow, and the TIAA Institute.
There are a few things we know can help keep our brains healthy as we age like exercise, social connection, learning a new skill, and creative expression. One activity combines all of these, but it might also bring back memories of early childhood embarrassment. In this episode, we explore dance as a tool for healthy aging, and why it may be one of the best things we can do for longevity.
Inside this episode
0:49 – Ballet at Any Age
Dr. Jason Karlawish explains why he began taking Vaganova ballet as an adult and the mental benefits he’s experienced.
4:11 – A Childhood Dance Disaster
Carolyn Hewson recounts her brief and traumatic first experience performing ballet and why she spent decades avoiding dance.
8:09 – The Dementia Prevention Dance Club
After experiencing the physical, cognitive, and social benefits of learning choreography, Carolyn and her fellow moms launch a monthly dance group.
9:40 – What Sets Dance Apart from Other Exercise
Dr. Julia Basso explains how dance engages multiple brain systems at once through movement, memory, rhythm, emotion, creativity, and social connection.
13:27 – Dance Movement Therapy
Dance movement therapist Natasha Goldstein-Levitas explains how therapeutic movement helps people living with dementia connect emotionally, physically, and socially.
17:05 – Dance for Parkinson's Disease
David Leventhal shares the origin story of Dance for PD, a program that began with six participants and grew into an internationally recognized model for movement and community.
20:27 – A Passion for Movement
Emily and Judy Tobey reflect on how Dance for PD became a vital source of physical activity, friendship, and purpose for their husband and father, Charlie.
24:54 – We Are Born to Dance
David Leventhal argues that dance is a fundamental part of human expression and that anyone can benefit, regardless of experience or ability.
29:34 – “There’s No Ceiling”
Dr. Karlawish discusses his favorite aspects of learning dance, including the social connection, the focus it brings him, and the chance to practice something with limitless offerings
Resources available on the episode webpage linked below
Special thanks to Carolyn Hewson, Dr. Julia Basso, Natasha Goldstein-Levitas, David Leventhal, Emily Tobey, Judy Tobey, Neil Godik, and today's hosts, Dr. Jason Karlawish and Jake Johnson.
The Age of Aging is a Penn Memory Center production hosted by Producer Jake Johnson and Executive Producer Jason Karlawish. Contributors include Morgann Adams, Terrence Casey, Dalia Elsaid, Holly Elser, Emily Largent, and Alison Lynn.
The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub Fund, Lena Chow, and the TIAA Institute.
At The Age of Aging, we often talk about the importance of physical activity and a healthy diet for brain longevity. However, one of the best things you can do to promote brain health as you age may also seem unlikely: hanging out with your friends.
In this episode, we explore the growing body of research linking social isolation and loneliness to cognitive decline and dementia risk. We’ll hear from older adults navigating loneliness, researchers studying its effects on the brain, and members of a unique housing community designed to help older adults stay connected.
Later, Terrence Casey, Jake Johnson, and Executive Producer Dr. Jason Karlawish reflect on what loneliness looks like in clinical practice, why social isolation can complicate dementia diagnosis and care, and what listeners can do to build stronger social connections throughout their lives.
Inside this episode
5:35 – Social Isolation and Brain Health
Dr. Holly Elser explains why social isolation is considered one of the 14 modifiable dementia risk factors and how social connection may help build cognitive reserve.
7:43 – The Dementia Risk of Isolation
Dr. Barbara Sahakian discusses research from the UK Biobank showing that socially isolated adults had a 26% increased risk of developing dementia.
11:13 – Grief, Purpose, and Feeling Alone
Frank Saar reflects on life after the death of his wife and the challenge of rebuilding a sense of purpose while coping with loneliness.
15:24 – A Community Built for Connection
Residents and staff from Morningside Gardens in New York describe how a Naturally Occurring Retirement Community (NORC) helps older adults stay socially engaged, active, and supported.
18:13 – The Social Lives of Healthy Agers
Philadelphia artist Jean Lindsay shares how decades of participation in community arts programs helped him build friendships and maintain a sense of purpose.
21:40 – “It’s Okay to Ask for Help”
Doris Kitt explains why loneliness is deeply personal and why older adults should seek support when isolation begins to affect their well-being.
24:39 – What Loneliness Looks Like in the Clinic
Jason Karlawish discusses how social isolation often appears early in dementia and why clinicians pay close attention to changes in a person's daily routines and social engagement.
34:13 – Finding Your Community Before You Need It
Jake and Jason discuss why building meaningful social connections earlier in life may be one of the most powerful investments people can make in their long-term brain health.
Resources available on the episode webpage linked below
Special thanks to Doris Kitt, Holly Elser, PhD, Barbara Sahakian, PhD, Frank Saar, Dana Minaya, Ron Bruno, Gene Renzi, as well as today's co-hosts, Terrence Casey, Jake Johnson, and Jason Karlawish, MD.
The Age of Aging is a Penn Memory Center production hosted by Producer Jake Johnson and Executive Producer Jason Karlawish. Contributors include Morgann Adams, Terrence Casey, Dalia Elsaid, Emily Largent, and Alison Lynn.
The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub Fund, Lena Chow, and the TIAA Institute.
Doris Kitt’s Poem on loneliness:
Life is fraught dear friends
That’s just how it is
The challenge is overcoming and
You don’t have to be a wiz
It’s okay to be sad
Just don’t let it linger
There are lots of things to do
To give loneliness the finger.
Remember the good ole days
And how life used to be
When things were really simpler
Now a memory to you and me.
Doing something different
And keeping busy too
Will bring about a change
You never knew you knew
Teach yourself a language
How hard could it be
Or simply go a fishin’
Or read a book beneath a tree.
Take the train to an unknown stop
Get off and have a cup of tea
Trying something new
Will bring a lot of joy to thee
Volunteer with children
Oh what a day you’ll have
And I guarantee that loneliness
Won’t seem so bad
The idea is to keep busy
Within your capable range
It will make you happy
And your mind will feel the change
Ride a bike. Go skating
Just doing something new
Will make your body healthy
I promise you.
The thoughts that make you lonely
Will be a thing of the past
Have faith. Have hope. Be joyful
And life will be a blast.
No matter what phase of life you’re in
Loneliness can be a drag
It will affect your welfare
And keep you in a bag.
Don’t delay in getting help
If that is what you need
You deserve to live a life of peace
So let others intercede.
What changes when dementia care becomes personal? In this bonus conversation, neuropsychologist Dr. Emma Rhodes sits down with Penn Memory Center Director of Social Work Alison Lynn to talk about caring for her father with Alzheimer’s disease, balancing caregiving with work, and how the experience has changed the way she sees patients and families.
The Age of Aging is a Penn Memory Center production hosted by Producer Jake Johnson and Executive Producer Jason Karlawish. Contributors include Morgann Adams, Terrence Casey, Dalia Elsaid, Emily Largent, and Allison Lynn.
The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub Fund and Lena Chow.
At the Age of Aging, we often speak with researchers and clinicians who have devoted their careers to understanding dementia and caring for the people living with it. Less often, we hear what happens when dementia becomes personal for those same experts.
In this episode, neuropsychologist Dr. Emma Rhodes shares her experience caring for her father, Jack, following his diagnosis of dementia due to Alzheimer's disease. In conversation with Penn Memory Center Director of Social Work Allison Lynn, Emma reflects on grief, stigma, caregiving, and the challenges of navigating life as both a dementia expert and a daughter. Then, Executive Producer Dr. Jason Karlawish and Editorial Director Terrence Casey unpack some of the interview's most powerful moments, connecting Emma's experience to broader lessons about caregiving and dementia care.
Inside this episode
4:18 – Daughter First, Neuropsychologist Second: Emma Rhodes reflects on the challenge of balancing her professional knowledge with the emotional reality of caring for her father.
7:52 – The Uncanny and Ambiguous Loss: Jason Karlawish discusses the profound grief family caregivers experience when a loved one is simultaneously familiar and changed by dementia.
12:45 – When Professional Calm Breaks Down: Jason shares a candid story about losing his composure while trying to help his father manage his finances.
16:03 – Dementia Stigma Firsthand: Emma describes how caring for her father revealed just how difficult and often unwelcoming the world can be for people living with cognitive impairment.
19:48 – Clinicians as Caregivers: Jason and Terrence explore why more healthcare professionals are speaking openly about their personal experiences with dementia in their own families.
28:15 – The Hidden Work of Caregiving: Emma discusses the emotional, logistical, and physical effort required to attend clinic visits, participate in research, and manage day-to-day care.
32:48 – “How Are You Doing?” Jason explains why one of the most important questions a clinician can ask a caregiver is also one of the simplest.
39:26 – “Our Families Are Your Patients Too”: Jason reflects on why healthcare systems must better recognize and support family caregivers as essential partners in dementia care.
Resources available on the episode webpage linked below
Special thanks to Emma Rhodes, PhD, Allison Lynn, LCSW as well as today's co-hosts, Terrence Casey and Jason Karlawish, MD.
The Age of Aging is a Penn Memory Center production hosted by Producer Jake Johnson and Executive Producer Jason Karlawish. Contributors include Morgann Adams, Terrence Casey, Dalia Elsaid, Emily Largent, and Allison Lynn.
The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub Fund and Lena Chow.
What makes a house a home? And what happens when that home no longer works for the person living in it? In this episode, we explore the emotional and practical challenges of downsizing and moving later in life — from letting go of decades of possessions to navigating dementia, family dynamics, and the fear of what comes next.
Inside this episode:
1:06 – Deconstructing Home: Dr. Jason Karlawish explores what makes a home more than just four walls and why dementia can change the way someone experiences their environment.
8:24 – Professional Downsizers: Move managers Susan Blumenfeld and Charlotte Schutzman explain the emotional and logistical challenges of helping older adults decide what stays, what goes, and what their possessions are really worth.
13:19 – 10x Harder: Kristi Mabe shares what it was like to move her own mother into assisted living, and why helping a family member can be much harder than helping a client.
20:56 – “It’s the People, It’s Not the Place”: Mary Ellen Weber shares how moving to a retirement community helped her and her husband find connection, independence, and a richer daily life.
25:00 – Tied to the Mast of Aging in Place: Dr. Karlawish discusses the risks of being too committed to living in one place when a home becomes isolating or no longer meets someone’s needs.
36:36 – Coming Home: Jake and Dr. Karlawish turn to The Odyssey to consider what really makes a place home.
Resources available on the episode webpage linked below
Special thanks this episode to Kristi Mabe, Charlotte Schutzman, Susan Blumenfeld, and Mary Ellen Weber, as well as today’s co-host, Jason Karlawish, MD.
The Age of Aging is a Penn Memory Center production hosted by Producer Jake Johnson and Executive Producer Jason Karlawish. Contributors include Morgann Adams, Terrence Casey, Dalia Elsaid, Emily Largent, and Allison Lynn.
The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub Fund.
Welcome to our annual summer bonus episode of the Age of Aging, where our Penn Memory Center experts reflect on the latest research from the annual Alzheimer’s Association International Conference (AAIC). On today’s episode, Age of Aging Executive Producer and PMC Co-Director Dr. Jason Karlawish sat down with Co-Director Dr. David Wolk and Dr. Chris Brown to unpack their biggest takeaways from their time in London. They discuss everything from new blood-based biomarkers to the latest data on anti-amyloid and tau-targeting therapies as well as what the future of Alzheimer’s treatment may look like.
The Age of Aging will return for Season 6 in September, so please make sure you’re subscribed wherever you get your podcasts, and we’ll see you soon.
Inside this episode:
2:40 – How AAIC Has Changed: The group compares this year's meeting to AAIC 2017 and discusses how the science has shifted to a more clinical focus.
9:26 – Predicting Brain Health: Dr. Brown and Dr. Wolk discuss where p-tau 217 stands as a biomarker as well as new markers like neuronal pentraxin (NPTX) for measuring synaptic health beyond amyloid and tau.
22:42 – The Blood-Brain Barrier: The clinicians provide an update on the two anti-amyloid therapies currently available as well as discuss the brain "shuttle" technology, which appears to significantly improve amyloid clearance and safety.
29:59 – Tau has its Moment: Results from the CELIA antisense oligonucleotide study show a "Goldilocks dose" effect, plus a look at a negative Lilly tau-lowering trial.
35:25 – Closing Highlights & What’s Next: Jason spotlights the LiBBY study, testing a THC/CBD combination for agitation in advanced dementia, before the group previews next year's AAIC 2027 meeting in Chicago.
Resources available on the episode webpage linked below
Special thanks this episode to Jason Karlawish, MD, David Wolk, MD, and Christopher Brown, MD, PhD.
If this episode, or another episode, has resonated with you, please subscribe, leave us a review, or share it with somebody who would appreciate it. This makes a real difference in helping others find the show. And if you have a topic you’d like to hear, email us at [email protected].
The Age of Aging is a Penn Memory Center production, hosted by Editorial Director Terrence Casey and Producer Jake Johnson. Contributors include Morgann Adams, Dalia Elsaid, Jason Karlawish, Emily Largent, Alison Lynn, and Mischa Norton.
The show is made possible by generous support from the Michael Naidoff Communications Hub Fund and Lena Chow.
At the Age of Aging, we are sometimes lucky enough to have too many great stories to fit into a single podcast episode. We ran into this fortunate circumstance last season with our episode, “Ambiguous Loss,” which shared the stories of two caregivers grappling with their loved one’s decline from dementia. On today's mid-summer bonus episode, we share a third story we recorded that didn’t make the cut – not because it wasn't good enough, but because it was too complete to be a piece of something else.
Margo Woodacre is an author, teacher, former state senator, and for eight years, the primary caregiver for her husband, Ernie, who was living with Alzheimer's. In this standalone conversation, Woodacre reflects on caregiving, grief, identity, and the slow work of asking, “Who am I now?” that followed the loss of Ernie.
Inside this episode:
2:02 – Becoming a Caregiver: Woodacre reflects on the early signs of Ernie’s Alzheimer’s disease, the fear that followed his diagnosis, and the emotional challenge of caring for someone whose personality was beginning to change.
6:18 – Learning to Dance in the Rain: After a difficult moment in Ernie’s illness, Woodacre shares how a neighbor’s advice helped her reframe caregiving, change her own responses, and meet Ernie where he was. In doing so, she learned how to reduce conflict, preserve connection, and keep finding meaningful moments with him.
10:26 – Delayed Grief: Woodacre reflects on the surprising sense of relief that followed Ernie’s passing, the administrative work of closing a life, and the delayed grief that emerged once the busyness faded.
13:49 – Losing and Reclaiming Identity: After years of caregiving, Woodacre found herself asking who she was without Ernie and without the caregiving role that had shaped her daily life. She discusses journaling, meditation, teaching, politics, support groups, and solo travel as part of her path back to herself.
16:20 – Traveling Alone Again: Woodacre shares the story of her first solo trip after Ernie’s death, a dude ranch vacation that began in loneliness and became a turning point in rebuilding confidence, openness, and independence.
19:08 – Advice for Grieving Caregivers: Woodacre offers guidance for people beginning the grieving process: take your time, allow yourself to grieve, but don’t stay so long in pain that you miss the next lesson life may still have to offer.
Resources available on the episode webpage linked below
Special thanks this episode to Margot Woodacre for sharing her story with us.
If this episode, or another episode, has resonated with you, please subscribe, leave us a review, or share it with somebody who would appreciate it. This makes a real difference in helping others find the show. And if you have a topic you’d like to hear, email us at [email protected].
The Age of Aging is a Penn Memory Center production, hosted by Editorial Director Terrence Casey and Producer Jake Johnson. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, Alison Lynn, Morgann Adams, and Mischa Norton.
The show is made possible by generous support from the Michael Naidoff Communications Hub Fund and Lena Chow.
At The Age of Aging, we know that the stories we tell about dementia shape the perceptions, resources, and, ultimately, the lived experience of people with the condition. As such, it is our number one priority to understand what narratives serve an aging population and which ones are better left in the past.
For the Season 5 finale, our team reflects on a special report from Hastings Center for Bioethics, Living with Dementia: Learning from Cultural Narratives of Aging Societies. Through a series of personal audio essays, some familiar voices from this season explore how cultural narratives influence the lived experience of dementia—and how new stories might help us build a more compassionate, creative, and supportive future.
Inside this episode:
4:21 – Managing Dependence: Dr. Jason Karlawish discusses Mercer Gary's essay on assistive technologies in dementia care. He explores the tension between fears of technological dependence and hopes that technology can eliminate dependence altogether.
11:47 – Creativity, Collaboration, and Dementia: Terrence Casey, editorial director and co-host of The Age of Aging, reflects on Julia Henderson's essay examining participatory arts programs and how projects like Anne Basting's Penelope Project challenge conventional narratives about dementia.
16:19 – Learning from History: Dr. Emily Largent discusses Jesse Ballenger's essay on the history of dementia. She explores how modern anxieties about cognitive decline are shaped by changing ideas about identity, aging, and selfhood.
20:15 – New Narratives for a More Just Future: Producer and Co-Host Jake Johnson examines how cultural narratives influence dementia care and why imagining ourselves into the lives of people living with dementia and caregivers is essential to meaningful social change.
25:34 – Rethinking Housing and Care: Dr. Holly Elser discusses supportive housing as a promising model for people living with dementia, offering an alternative to the traditional divide between aging in place and institutional care.
28:14 – Season 5 Reflections: Dr. Jason Karlawish, Jake Johnson, and Terrence Casey discuss their favorite episodes from the season, lessons learned from reporting on aging and dementia, and what listeners can expect this summer and in Season 6.
Resources available on the episode webpage linked below
Special thanks this episode to Jason Karlawish, MD, Emily Largent, PhD, JD, RN, Jake Johnson, and Holly Elser, MD, PhD, MPH.
The Age of Aging is a Penn Memory Center production, hosted by Editorial Director Terrence Casey and Producer Jake Johnson. Contributors include Dalia El Said, Jason Karlawish, Emily Largent, Alison Lynnn, and Morgann Adams.
The show is made possible by generous support from the Michael Naidoff Communications Hub Fund and Lena Chao.
Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, families across New Jersey and Pennsylvania receive guidance through every stage of the aging journey. Their team of elder care attorneys, geriatric care coordinators, care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind.
Rothkoff Law Group — your partner in elder care advocacy and senior care planning every step of the way. Visit RothkoffLaw.com for more information.
The air around us is invisible, but its effects on the brain are becoming harder to ignore. Research now links long-term exposure to air pollution with increased Alzheimer's pathology, cognitive decline, and greater dementia risk, and older adults face the greatest threat.
On this episode of The Age of Aging, we go inside that science. Dr. Eddie Lee shares new findings from the University of Pennsylvania connecting lifetime particulate matter exposure to amyloid and tau buildup in the brain. Toxicologists, lung health experts, and clean air advocates explain what air pollution actually is, why Philadelphia's air quality ranks among the most concerning of major American cities, and what individuals and communities can do to protect themselves. And Dr. Holly Elser joins host Terrence Casey to explore the broader relationship between environment, place, and brain health — and why the fight for clean air is also a fight for healthy aging.
Inside this episode:
5:45 – Air Pollution and Alzheimer’s Disease: Dr. Eddie Lee explains how his team linked lifetime exposure to particulate air pollution with increased amyloid and tau pathology in the brain.
9:27 – What Is Air Pollution?: Dr. Trevor Penning and Bev Stewart break down the science of particulate matter, ozone, and toxic gases, and explain why older adults are particularly susceptible to their harmful effects.
13:06 – Philly’s Air Quality: Clean Air Council advocate Russell Zerbo discusses the biggest contributors to air pollution in Philadelphia, including transportation, industry, and urban density, and what local efforts are underway to improve air quality.
15:01 – Protecting Yourself: Experts share practical steps individuals can take to reduce exposure to poor air quality, from tracking the Air Quality Index and wearing N95 masks to improving indoor air filtration.
22:08 – Environment and Brain Health: Dr. Holly Elser joins Terrence Casey to discuss the emerging science connecting environmental exposures and dementia risk, the importance of policy solutions, and how climate and place shape healthy aging.
Resources available on the episode webpage linked below
Special thanks this episode to Eddie Lee, MD, PhD, Trevor Penning, PhD, Russell Zerbo, Bev Stewart, and Holly Elser, MD, PhD, MPH.
The Age of Aging is a Penn Memory Center production, hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn.
The show is made possible by generous support from the Michael Naidoff Communications Hub Fund and Lena Chow
Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, families across New Jersey and Pennsylvania receive guidance through every stage of the aging journey. Their team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind.
Rothkoff Law Group — your partner in elder care advocacy and senior care planning every step of the way. Visit RothkoffLaw.com for more information.
At the Salvation Army Ray and Joan Kroc Center in Philadelphia, our Golden Gems Senior Program offers a welcoming space for older adults to stay active, connected, and inspired. We meet every Tuesday, Wednesday and Friday from 10 a.m. to 2 p.m. for uplifting devotions, engaging activities, educational workshops and a shared lunch. Members also enjoy occasional outings and special trips throughout the year. For just $18 a month, participants gain access to a vibrant community focused on wellness, friendship and purpose. To learn more or join us, visit the Kroc Center and become part of our Golden Gems family.
From the publisher's feed

112,160 Listeners

147 Listeners

9,104 Listeners

7,942 Listeners

28,942 Listeners

16,169 Listeners

18,120 Listeners