This first episode delves into the clinical aspects of the Cryopyrin-Associated Periodic Syndromes and includes some helpful tips for sorting out some of the autoinflammatory diseases in the spectrum.

• Intro :10
• Cryopyrin-Associated Periodic Syndromes (CAPS) :25
• Outline of Part 1 2:25
• What is CAPS? 3:12
• Case #1 – a 25-year-old female with urticaria after cold exposure 4:25
• Case #2 – a 55-year-old female with progressive deafness 5:45
• The index case of familial cold autoinflammatory syndrome 9:00
• The final disease in the spectrum 11:00
• A lot of names for the same disease 13:50
• Genetics prove these three diseases are in the same spectrum 14:22
• Over 100 mutations have been found to-date 16:31
• Let’s talk about mosaicism 17:03
• Disease characteristics of CAPS 18:15
  • Neutrophilic infiltrate in chronic urticaria vs. CAPS 20:00
  • Schnitzler syndrome 20:45
  • Sensorineural hearing loss 21:58
  • Joint pain 24:10
• Complication: Amyloidosis 25:29
• These diseases were very debilitating 28:38
• Episode recap 29:46
• Part 2 sneak peek 30:38
• Come say hi at ACR! 30:51

We’d love to hear from you! Send your comments/questions to [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum

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