In 1846, an Italian chemist discovered the volatile compound nitroglycerine, the first major breakthrough in creating man-made explosions since the invention of gunpowder a thousand years earlier. But almost everyone who experiments with the compound thinks it’s too dangerous for any commercial application–everyone except for one brooding, obsessed young Swedish inventor named Alfred Nobel. 

Nobel dreams of harnessing the chemical’s power to ignite an engineering revolution: blasting railway tunnels, digging out mines and canals…. But as Nobel’s quest to tame nitroglycerine becomes increasingly central to his family’s livelihood, it also repeatedly puts his own life in danger.

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As the first in a series on fighting the COVID-19 pandemic, Steven Johnson speaks with Dr. Bruce Gellin, president of Global Immunization at the Sabin Vaccine Institute in Washington D.C.. Dr. Gellin is also a former director of the National Vaccine Program at the Department of Health and Human Services, and led the creation of HHS’s first pandemic influenza preparedness and response plan. They talk about a very new and pressing challenge: how to speed up vaccine development for COVID-19.

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A century ago, organ transplants were the stuff of science fiction. But a handful of experimental surgeons believed that transplants were not just possible – they had the potential to save thousands of lives. Then, in 1954, a man agreed to donate his kidney to his twin brother – and one surgeon finally got his chance to prove the doubters wrong.

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Anxiety. It’s something everyone experiences at some point in their lives, but for centuries doctors had no effective way to treat it. They could send patients on rest cures, order them to do nothing at all, or prescribe barbiturates that depressed the central nervous system, easily leading to overdose and death.

Finally, in the mid-1950s, chemists discovered a new class of drugs: the minor tranquilizers. The most famous of these was Valium, which would go on to become the most prescribed drug in the United States.  

But Valium owes its success to its lesser known predecessor Miltown, which changed the way Americans thought about anxiety.

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The invention of the electronic television was uniquely complicated for its time. So complicated, in fact, that the prevailing narrative is that it couldn’t have been invented by a single person -- let alone Philo Farnsworth. 

After all, some of the most brilliant minds in the world spent the first quarter of the 20th century working on television systems -- and some even managed to transmit images. But none of those systems were ever able to deliver the quality of images they’d need to be commercially viable. None except Philo Farnsworth, a farm boy from Utah, who got the idea for television when he was fourteen years old. 

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Today, if we want to take a photo, we unlock our phone, aim, and click. It can be done on a whim, without a second thought. We document everything from new haircuts to latte art, cute cats to baby’s first smile. But prior to the 1900s, photography was the exclusive domain of professionals and dedicated hobbyists -- people willing to learn complex skills and spend hours on the craft.

Responsible for that shift was a man named George Eastman. Armed with a radical vision for what photography could be, and a cold-blooded business sense, Eastman delivered photography to the masses and altered the way most of us experience our lives over time.

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Today, if you or someone you know experiences a medical emergency, you dial 9-1-1 and a squad of trained medical professionals arrives at your door. But just 55 years ago, that was not the case.

Emergency calls were generally dispatched to funeral homes simply because their vehicles were suited to transporting bodies. You’d be lucky if the person transporting you had any first aid training at all. A soldier shot in Vietnam had a better chance of surviving than a housewife in a car accident because the soldier in Vietnam got immediate trained medical care.

Throughout the 1960s, volunteer rescue squads began experimenting with different kinds of pre-hospital care. But in Pittsburgh, 20th century topography converged with the fates of a few individuals, and one ambitious vision, to spin a medical revolution into being.

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