Over the four decades since the pandemic took off, we have seen around 40 million people worldwide killed by HIV. Today, around the same number of people are living with the virus, and many of them are long-term survivors. In 2015, an end to the pandemic by 2030 was adopted as one of the ambitious UN Sustainable Development Goals and signed up to by all member states. Sue Armstrong and Noerine Kaleeba report on the impressive progress made in controlling the spread of HIV and ask whether the goal of an end to the Aids pandemic by 2030 is really possible.