NP Certification Q&A

Antidepressant Discontinuation Syndrome


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A 38-year-old woman presents for a sick visit with a two-day history of, "not feeling right. I've never felt like this before." Approximately four days ago, she self-discontinued a standard dose SSRI after taking this medication for the past 18 months, stating, "I feel like my depression had gotten much better." She denies alcohol or recreational drug use. When considering the diagnosis of antidepressant discontinuation syndrome, which of the following is most likely to be reported?

A. tremor, diaphoresis, tachycardia, hypertension, agitation

B. yawning, rhinorrhea, abdominal cramping, diarrhea, piloerection

C. dizziness, nausea, body aches, sleep disturbance, irritability, brief vibrating sensations

D. restlessness, sweating, diarrhea, tremor, fever, and involuntary muscle jerking

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