Please visit answersincme.com/JXV860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in metastatic non–small-cell lung cancer discusses how to optimize frontline immunotherapy-based regimens for long-term outcomes. Upon completion of this activity, participants should be better able to: Identify patients with metastatic NSCLC who may benefit from first-line immunotherapy-based regimens; Evaluate the long-term evidence on first-line immunotherapy-based regimens for the treatment of patients with metastatic NSCLC; and Outline evidence-based, patient-centered strategies to ensure optimal use of first-line immunotherapy-based regimens, from initiation to follow-up care after discontinuation, in patients with metastatic NSCLC.